Establishment and Evaluation of a Porcine Vein Graft Disease Model

Innovative Animal Models Of Cardiac Remodeling: Development And Evaluation

“…, programmed electrical stimulation-induced cardiac arrhythmias in mice 5 , vein graft disease induced by coronary artery bypass grafting (CABG) in pigs 6 , cardiac volume overload due to aortic regurgitation in mice 7 , heart failure with preserved ejection fraction (HFpEF) induced by descending aortic constriction in pigs 8 , combined angiotensin II infusion and renal denervation to control blood pressure in mice 9 , and mutations in a human homologous gene, cardiac myosin heavy chain 7 gene (MYH7), in mouse hearts 10 . In addition, the authors provide detailed protocols for assessing cardiac remodeling using cardiac magnetic resonance feature tracking (CMR-FT) in patients 11 , echocardiography in mice and pigs 4 , 7 , 8 , 10 , electrophysiological recordings in mice 5 , hemodynamics measurements in mice 4 , 7 , mouse or pig heart histology 4 , 6 , 7 , 8 , 9 , 10 , and biomarkers 6 , 8 , 9 .…”

“…However, vein grafts can undergo pathological changes and re-occlude after surgery, leading to vein graft disease 17 . Li et al 6 detail a porcine CABG procedure using the internal mammary vein as a graft 6 . In addition, the authors demonstrate the method of pig tracheal intubation and the harvesting procedure of the left internal mammary vein.…”

Innovative Animal Models Of Cardiac Remodeling: Development And Evaluation

“…, programmed electrical stimulation-induced cardiac arrhythmias in mice 5 , vein graft disease induced by coronary artery bypass grafting (CABG) in pigs 6 , cardiac volume overload due to aortic regurgitation in mice 7 , heart failure with preserved ejection fraction (HFpEF) induced by descending aortic constriction in pigs 8 , combined angiotensin II infusion and renal denervation to control blood pressure in mice 9 , and mutations in a human homologous gene, cardiac myosin heavy chain 7 gene (MYH7), in mouse hearts 10 . In addition, the authors provide detailed protocols for assessing cardiac remodeling using cardiac magnetic resonance feature tracking (CMR-FT) in patients 11 , echocardiography in mice and pigs 4 , 7 , 8 , 10 , electrophysiological recordings in mice 5 , hemodynamics measurements in mice 4 , 7 , mouse or pig heart histology 4 , 6 , 7 , 8 , 9 , 10 , and biomarkers 6 , 8 , 9 .…”

“…However, vein grafts can undergo pathological changes and re-occlude after surgery, leading to vein graft disease 17 . Li et al 6 detail a porcine CABG procedure using the internal mammary vein as a graft 6 . In addition, the authors demonstrate the method of pig tracheal intubation and the harvesting procedure of the left internal mammary vein.…”