1983
DOI: 10.1002/ijc.2910310202
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Establishment and characterization of a human non‐secretory plasmacytoid cell line and its hybridization with human B cells

Abstract: A human non-secretory plasmacytoid cell line has been established for 6 years in more than 170 passages. Over 300 passages have been made from several early and late passages. The cell line is karyotypically normal, easily grown and has the characteristic features of a non-secretory plasmablast. Its characteristics suggest its use for hybridization by new methods as well as a study of its secretory defect. HPRT-negative phenotypic mutants can be derived from this line and a single polyploid clone has also been… Show more

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Cited by 42 publications
(6 citation statements)
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“…We investigated these issues in a myeloma model consisting of eight different myeloma-and plasma-cell leukaemia lines, which have been extensively characterized Nishiuchi et al, 1996;Ritts et al, 1983). Our results indicated a constitutive expression of Bcl-2 and a high variability in the relative expression level of the Apo-1/Fas antigen in all of the eight myeloma cell lines investigated.…”
mentioning
confidence: 94%
See 1 more Smart Citation
“…We investigated these issues in a myeloma model consisting of eight different myeloma-and plasma-cell leukaemia lines, which have been extensively characterized Nishiuchi et al, 1996;Ritts et al, 1983). Our results indicated a constitutive expression of Bcl-2 and a high variability in the relative expression level of the Apo-1/Fas antigen in all of the eight myeloma cell lines investigated.…”
mentioning
confidence: 94%
“…Two additional cell lines were used in this study (i.e. the ARH-77 (Nishiuchi et al, 1996) and the MC/CAR (Ritts et al, 1983)). The IM-9, OPM-2, LP-1 and L363 cell lines were obtained from DSM (German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany), the RPMI 8226, ARH-77, MC/CAR and HS-Sultan cell lines from the American Type Culture Collection (Rockville, Md., U.S.A.).…”
Section: Methodsmentioning
confidence: 99%
“…The examination was performed in a myeloma cell line model, consisting of the Apo-1IFas-sensitive IM-9, LP-1, RPMI-8226, ARH-77 and MUCAR cell lines [17][18][19]. IFN-a, exerted a marked growth inhibition on myeloma cells when incubated for 48 h, but this effect was not caused by the induction of apoptosis.…”
Section: Introductionmentioning
confidence: 99%
“…These problems have also been encountered in most, though not all, of the fusions of antigen-primed human B lymphocytes with EBV-transformed B lymphoblastoid cell. lines (LCL) (8,(21)(22)(23)(24)(25)(26)(27)(28). Moreover, such hybridomas usually secrete permuted immunoglobulin molecules derived from both fusionpartners.…”
mentioning
confidence: 99%