2022
DOI: 10.1101/2022.09.04.506533
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Establishment and characterization of a tumoroid biobank derived from dog patients’ mammary tumors for translational research

Abstract: Breast cancer is the most frequent cancer among women causing the greatest number of cancer-related deaths. Cancer heterogeneity is a main obstacle to therapies. Around 96% of the drugs fail from discovery to the clinical trial phase probably because of the current unreliable preclinical models. New models emerge such as companion dogs who develop spontaneous mammary tumors resembling human breast cancer in many clinical and molecular aspects. The present work aimed at developing a robust canine mammary tumor … Show more

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