Abstract:Purpose
Colorectal cancer (CRC) is the third leading cause of cancer-related mortalities in Korea. It is also the third most frequently diagnosed malignancy worldwide. To significantly improve its oncologic outcome, there is a need to study the diagnosis and treatment strategies further.
Methods
We established 21 patients-derived organoids from 20 patients with CRC, and characterized their cellular and molecular features. Whole exome sequencing (WES) was performed for these organoids to obtain mutational pro… Show more
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