Establishment and Advancement of Pancreatic Organoids

Abstract

Following the reporting of the first organoids, the development and application of tissue-specific organoids has expanded considerably in fields such as stem biology, regenerative medicine, oncology, biotechnology, and precision medicine. In addition, pancreatic organoids generated sequentially from pancreatic duct tissue, tumor tissue, and pluripotent stem cells, are increasingly used in research on stem cells, pancreatic islets, pancreatic ducts, type 1 diabetes, and pancreatic ductal adenocarcinoma. This article introduces organoids in general and reviews recent studies on the use of pancreatic organoids in particular.