Establishing the Taxa, Functional profile, and in-silico Ayurvedic Remedy of Microbiota implicated in West Nile Fever

Abstract

West Nile fever causing microbiome is taken in this work. Culex nigripalpus mosquito is the causative factor for West Nile Virus. Using Metatranscriptomic sequencing, identified the taxa and functional profile of the microbiome is identified. Again, the receptor genes involved in West Nile fever is taken and using computer aided drug design, the novel ligands from Ayurvedic medicinal plants Ginkgo biloba, Uncaria tomentosa, Lycoris radiate and Glycyrrhiza glabra. Further, in-vitro and in-vivo studies can be done on the selected ligands to prove their efficiency as drugs for the disease