Establishing the Incidence and Prevalence of Multiple Sclerosis in Saskatchewan

Al-Sakran, Lina; Marrie, Ruth Ann; Blackburn, David; Knox, Katherine; Evans, Charity

doi:10.1017/cjn.2017.301

Cited by 55 publications

(69 citation statements)

References 25 publications

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“…Access to professional support and specialized equipment for exercise is a challenge especially in areas with a high MS prevalence, yet low population density, as is the case in Saskatchewan, Canada. 7 A key question remains concerning how best to support persons with MS in participating and adhering to their exercise programs. Various web-based approaches have been proposed to meet this challenge.…”

Section: Introductionmentioning

confidence: 99%

Adherence to Physiotherapy-Guided Web-Based Exercise for Persons with Moderate-to-Severe Multiple Sclerosis

Donkers¹,

Nickel²,

Paul³

et al. 2020

International Journal of MS Care

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Background: Options to support adherence with physical activity in moderate-to-severe MS are needed. The primary aim was to evaluate adherence to a web-based, individualized exercise program in moderate-to-severe MS. Secondary aims were to explore changes in MSIS-29, HADS, grip strength, T25FWT, and TUG. Methods: Inclusion criteria were diagnosis of MS, internet access, residing within 300 km of Saskatoon, and exercising less than twice weekly. Participants were randomized (2:1) to a physiotherapist-guided web-based home exercise program or physiotherapist-prescribed written home exercise program. The primary outcome was adherence (number of exercise sessions over 26 weeks). Secondary outcomes were described in terms of means and effect sizes. Results: There were 48 participants: mean age 54.3y (SD 11.9), disease duration 19.5y (SD 11.0) and mean Patient-Determined Disease Steps 4.4 (SD 1.6). There was no significant difference in adherence between groups: web group (mean 38.9, SD 28.1); comparator group (mean 34.6, SD 40.8; U = 198.5, P = .208, Hedges' g 0.13). Nearly 50% of participants (23/48) exercised ≥ twice per week for at least 13 of the 26 weeks. Adherence was highest in the web-based subgroup of wheelchair users. Medium effect sizes were found for HADS - anxiety subscale and in ambulatory participants for TUG. There were no adverse events. Conclusions: There was no difference in exercise adherence between the web-based and active comparator groups. There was no worsening on secondary outcomes or adverse events, supporting the safety of web-based physiotherapy. More research is needed to determine if wheelchair users might be most likely to benefit from web-based physiotherapy.

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Section: Introductionmentioning

confidence: 99%

Adherence to Physiotherapy-Guided Web-Based Exercise for Persons with Moderate-to-Severe Multiple Sclerosis

Donkers¹,

Nickel²,

Paul³

et al. 2020

International Journal of MS Care

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“…We identified all subjects with MS between January 1, 1996 and December 31, 2017 using a previously validated case definition requiring ≥3 claims for either hospital (ICD-9: 340, ICD-10-CA: G35), physician (ICD-9: 340) or an MS-specific disease-modifying drug (Appendix A) (Al-Sakran et al, 2018). The first date of any medical contact for MS or a demyelinating condition (Appendix B) was considered as the date of "diagnosis", (Marrie et al, 2010) and designated as the index date.…”

Section: Study Cohortmentioning

confidence: 99%

Impact of comorbidity on hospitalizations in individuals newly diagnosed with multiple sclerosis: A longitudinal population-based study

Al-Sakran

Marrie

Blackburn

et al. 2020

Multiple Sclerosis and Related Disorders

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Background: It has been suggested that comorbidity in subjects with multiple sclerosis (MS) increases the risk of hospitalizations, although few studies have examined this, and rarely in an incident population. Methods: Incident MS cases were identified retrospectively from administrative data in Saskatchewan, Canada (1996-2017) using a validated definition (≥3 hospital, physician or drug claims for MS); the date of the first claim for MS or a demyelinating condition was considered the index date. All hospitalizations occurring after the index were included in the analyses. Comorbidity was defined in 3 ways: any comorbidity (yes/no); a total count of comorbidity (0, 1, or ≥2); and by individual comorbidities. The impact of comorbidity on all-cause hospitalizations was examined with negative binomial regression models fitted with generalized estimating questions. In subjects with at least one hospitalization during the follow-up period, we examined associations between comorbidity and MS-related hospitalizations logistic using regression models fitted with GEE. Results: Subjects with comorbidity had a higher rate of all-cause hospitalizations compared to those without any comorbidity (aRR 1.72; 95% CI: 1.48-1.99); comorbidity did not increase the odds of having an MS-specific hospitalization (aOR 0.76; 95% CI: 0.59-0.99). Individual comorbidities including diabetes, ischemic heart disease, chronic lung disease, epilepsy, and mood disorders increased the rate of all-cause hospitalizations, but had little impact on MS-related hospitalizations. A longer disease duration was associated with decreased allcause and MS-specific admissions. Conclusion: Comorbidity increased the rate of all-cause, but not MS-specific, hospital admissions. Hospitalization rates were higher during the earlier stages of MS. Therefore, recognizing and managing comorbidity in the MS population, especially early in the disease course, will likely have the biggest impact on reducing overall hospital admissions.

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“…In the present population-based MS registry, 21,580 cases of MS were registered and included in the analysis. 5 Table 1.…”

Section: Age At Disease Onset and Its Trendsmentioning

confidence: 99%

Evidence of an Increased Prevalence of Multiple Sclerosis: A Population-Based Study of Tehran Registry during 1999–2018

Almasi‐Hashiani

Sahraian

Eskandarieh

2020

Preprint

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Background: The epidemiological characteristics of multiple sclerosis (MS) have been investigated in various studies, which have revealed that the prevalence of MS varies across countries. The present study was conducted to investigate the longitudinal prevalence of MS in Tehran, Iran. Methods: The present population-based study was conducted in Tehran, the capital of Iran from 1999 to 2018 based on the annual report data provided by the Iranian MS Society (IMSS) registry system. The age-standardized and crude prevalence were estimated using population data presented by the Statistical Centre of Iran. Results: A total of 21,580 MS cases were registered and included in the analysis. Among the participant patients, 24.99% (5,393) and 75.01% (16,187) of cases were male and female, respectively. The mean age of MS onset was 28.8 years (S.D: 8.7). The age-standardized prevalence (ASP) of MS increased from 73.7 (95%CI: 72.1-75.2) per 100,000 people in 2006 to 137.6 (95% CI: 135.7-139.5) per 100,000 people in 2018. The ASP of MS in 2018 was estimated to be 67.9 (95%CI: 66.0-69.8) and 207.3 (95%CI: 204.0-210.7) per 100,000 people among males and females, respectively. The age-standardized female-to-male ratio of MS ranged from 3.7 (in 2010) to 2.06 (in 2017). Conclusion: The findings of this study suggested that the prevalence of MS in Tehran province is relatively high, and the occurrence of the disease is more common in the age groups under 40 years as compared with older-aged groups. In line with reports provided for various regions of the world, the prevalence of MS was higher among women. Similarly, the findings of this study revealed that the female-to-male ratio was 2.14 in 2018.

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Establishing the Incidence and Prevalence of Multiple Sclerosis in Saskatchewan

Cited by 55 publications

References 25 publications

Adherence to Physiotherapy-Guided Web-Based Exercise for Persons with Moderate-to-Severe Multiple Sclerosis

Adherence to Physiotherapy-Guided Web-Based Exercise for Persons with Moderate-to-Severe Multiple Sclerosis

Impact of comorbidity on hospitalizations in individuals newly diagnosed with multiple sclerosis: A longitudinal population-based study

Evidence of an Increased Prevalence of Multiple Sclerosis: A Population-Based Study of Tehran Registry during 1999–2018

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