Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review

Selvin, Sneha Teresa; Thomas, Sonu K.; Bikeyeva, Viktoriya; Abdullah, Ahmad Makmom; Radivojevic, Aleksandra; Jad, Anas A Abu; Ravanavena, Anvesh; Ravindra, Chetna; Igweonu-Nwakile, Emmanuelar O; Ali, Safina; Paul, Salomi; Yakkali, Shreyas; Balani, Prachi

doi:10.7759/cureus.27188

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…In particular, virulent strains of H. pylori infection (e.g., CagA-positive (cytotoxin-associated gene A-positive) cause a stronger inflammatory response in the gastric mucosa and throughout the body [ 24 ]. Chronic H. pylori infection can predispose people to bone loss and osteoporosis, as bone cells are sensitive to pro-inflammatory cytokines [ 25 ]. Our study found that H. pylori may affect osteoporosis through serum albumin, HDL, fasting blood glucose and vitamin D, Which may be involved in the link that H. pylori infection stimulates local and systemic inflammatory factors acting on this aspect of bone conversion.…”

Section: Discussionmentioning

confidence: 99%

H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study

Zhang,

Wei

et al. 2024

BMC Infect Dis

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Purpose There is controversy concerning the relationship between Helicobacter pylori (H. pylori) infection and osteoporosis. This study is to examine the causal relationship between H. pylori infection and osteoporosis and to analyze the potential mechanism underlying the relationship. Methods The clinical data of H. pylori infection and bone mineral density from patients or physical examiner with good general condition in our hospital between September 2019 and September 2020 were retrospectively collected. The relationship between H. pylori infection and osteoporosis was compared and analyzed, using logistic regression to examine the potential mechanism underlying the association. To investigate the causal effects of H. pylori infection and osteoporosis, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis. Results A total of 470 patients were positive for H. pylori, with a detection rate of 52.22%. It was found that age, SBP, FPG, DBP, ALB, LDL-C, hs-CRP, and OC were positively correlated with osteoporosis, while negative correlations were observed with BMI, LYM, ALB, TP, TG, HDL-C, SCr, UA, and VitD. After stratified analysis of sex and age, it was found that there was a significant correlation between H. pylori infection and osteoporosis. The levels of SBP, ALP, FPG, LDL-C, hs-CRP, and OC in both H. pylori-positive group and osteoporosis group were higher than those in the H. pylori-negative group while the levels of BMI, ALB, TP, HDL-C, SCr, UA, and VitD in the positive group were significantly lower than those in the negative group. Logistic regression analyses with gender and age showed that ALB, FPG, HDL-C, and VitD were common risk factors for osteoporosis and H. pylori infection. In the MR analysis, the IVW results found a positive effect of H. pylori infection on osteoporosis (OR = 1.0017, 95% CI: 1.0002–1.0033, P = 0.0217). Regarding the reverse direction analysis, there was insufficient evidence to prove the causal effects of osteoporosis on H. pylori infection. Conclusion Our study provides evidence for causal effects of H. pylori infection on osteoporosis. H. pylori may affect osteoporosis through serum albumin, high-density lipoprotein, fasting blood glucose and vitamin D.

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Section: Discussionmentioning

confidence: 99%

H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study

Zhang,

Wei

et al. 2024

BMC Infect Dis

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“…The age of the patient and the location of the ulcer-gastric or duodenal affect the clinical manifestations of the disease. However, in general, patients who present with burning, postprandial fullness, or early satiety raise the suspicion of PUD [ 1 , 2 ]. Upper gastrointestinal bleeding, perforation, and blockage are among PUD complications.…”

Section: Introductionmentioning

confidence: 99%

A Conservative Management of Perforated Peptic Ulcer: A Case Report

Abdalgalil,

Ismail,

Alshmaily

et al. 2024

Cureus

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Peptic ulcer disease (PUD) is a surgical emergency that affects the mucosal lining of the stomach or proximal intestine. Complications of PUD include upper gastrointestinal hemorrhage, perforation, and obstruction. The primary management approach for perforated peptic ulcers is surgery, but conservative management can be conducted in selected cases. A 54-year-old female was referred to the surgical unit with a history of severe upper abdominal pain and repeated vomiting. No other symptoms were reported and there was no significant medical or family history except the history of non-steroidal anti-inflammatory drugs. Examination revealed that the patient had a medical condition. was vitally stable with tenderness in the upper abdomen, in particular the epigastric and right hypochondrial, but no signs of generalized peritonitis. Her white cell count was elevated at 24,000x10^3/UL, and a C-reactive protein of 45.5 mg/dL. An upright CXR revealed the classic gas under the diaphragm. Abdominal CT with oral gastrograffin identified the diagnosis of perforated duodenal ulcer without ulcer leak. The case was treated by conservative management started with resuscitation, nil per os, IV fluid, IV antibiotics, and close observation and the patient was stable with no complications and completed the nonoperative management successfully till discharge after 10 days of hospital stay. The case illustrates that although this condition is uncommon to be treated without surgical intervention, there are some factors and criteria for successful NOM. Peptic ulcer perforation is a life-threatening surgical emergency. Surgery is the standard treatment for PPU and NOM can be conducted safely and successfully in highly selected cases. the surgeon should keep a wide safety window while providing nonstandard management with readiness to operate at any time. We believe that the main factor in successful nonsurgical management of our case is being fasted for a long time before perforation.

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Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review

Cited by 2 publications

References 46 publications

H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study

H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study

A Conservative Management of Perforated Peptic Ulcer: A Case Report

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