Establishing Novel Cell Factories Producing Natural Pigments in Europe

Tolborg, Gerit; Isbrandt, Thomas; Larsen, Thomas Ostenfeld; Workman, Mhairi

doi:10.1002/9781119166191.ch2

Cited by 3 publications

(1 citation statement)

References 131 publications

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“…the so-called Monascus pigments (Gao et al 2013 ), including the newly described subclass atrorosins of which we recently reported nineteen new analogues (Isbrandt et al 2020 ). The exact biosynthetic pathway of these compounds have not been fully elucidated, although some work has been done in order to propose a possible route (Hajjaj et al 1999 ; Somoza et al 2012 ; Liu et al 2014 ; Woo et al 2015 ; Chen et al 2017 ; Tolborg et al 2017 ). We therefore expect that the compounds described in this study are biosynthesised in a similar fashion, as outlined in Fig.…”

Section: Discussionmentioning

confidence: 99%

New azaphilones from Aspergillus neoglaber

et al. 2020

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Three new azaphilones, sassafrin E (1), sassafrin F (2), and sassafrinamine A (3), were isolated from the filamentous fungus Aspergillus neoglaber. The structures of the compounds were determined by nuclear magnetic resonance spectroscopy, and were found to be novel analogues of two already known compound classes; sassafrins and berkchaetoazaphilones. Sassafrin E and F were both oxygen containing, while sassafrinamine A additionally contained a nitrogen atom, originating from an aminoethanol moiety, as well as extensive conjugation resulting in an intense purple colour of the pure compound. The structure of sassafrin E was further confirmed using deuterium exchange experiments coupled with high-resolution tandem mass spectrometry.

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