Establishing motion control in children with autism and intellectual disability: Applications for anatomical and functional MRI

Cox, Alison; Virués‐Ortega, Javier; Julio, Flávia; Martin, Toby L.

doi:10.1002/jaba.351

Cited by 52 publications

(52 citation statements)

References 39 publications

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“…Pre-visit interview with parents to identify individualised reinforcers and preferred Interestingly, we found some preliminary evidence that out-of-scanner head motion could predict that observed in-scanner during the MRI scan. This secondary finding is consistent with recent efforts to mitigate the effects of head motion with real-time feedback during mock training, where outcomes in head movement reduction were demonstrated to be generalizable to an actual MRI setting (Cox, Virues-Ortega, Julio, & Martin, 2017;Greene et al, 2018). The procedure involves training participants to reduce head movement by providing immediate visual feedback once head motion exceeds a certain threshold.…”

Section: Discussionsupporting

confidence: 84%

Individualised MRI training for paediatric neuroimaging in autism spectrum disorders: A child-focused approach

Barton

Williams

et al. 2018

Preprint

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Magnetic Resonance Imaging (MRI) in paediatric cohorts is often complicated by reluctance to enter the scanner and head motion-related imaging artefacts. The MRI scanner environment is highly unusual and may distress younger cohorts, especially in children with sensory sensitivity and separation anxiety. The issue is particularly challenging in children with Autism Spectrum Disorders (ASD), where delivery of instructions for novel task demands in an unfamiliar setting may be limited or less effective due to communication disorder or intellectual disability. These issues together often give rise to excessive head motion that can significantly reduce the quality of images acquired, or render data unusable. Here we report an individualised MRI training procedure that enables young children with ASD to better tolerate the MRI scanner environment based on a child-focused approach and an individualised familiarisation strategy. The training procedure was implemented in a locally recruited study of monozygotic twins (n=12; 6 twin pairs; age range 7.1 to 12.85 years) concordant or discordant for ASD. MRI image quality indices were better or comparable to images acquired from an independent multi-centre ASD cohort. The success of these findings is promising and may be useful to improve the quality of paediatric neuroimaging in similar clinical populations.

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Section: Discussionsupporting

confidence: 84%

Individualised MRI training for paediatric neuroimaging in autism spectrum disorders: A child-focused approach

Barton

Williams

et al. 2018

Preprint

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“…Individuals with FXS and other types of ASD may experience claustrophobia and anxiety when asked to enter a scanner. For this reason behavioral psychologists have developed mock scan techniques to desensitize individuals with FXS and other developmental disabilities to maintain a stationary position for the duration of scans (12)(13)(14). Higher functioning individuals with FXS can typically be trained with a mock scanner to complete the process with an actual scan.…”

Section: Stillnessmentioning

confidence: 99%

The Urgent Need for Molecular Imaging to Confirm Target Engagement for Clinical Trials of Fragile X Syndrome and Other Subtypes of Autism Spectrum Disorder

2019

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Promising therapeutic agents for the symptoms in animal models of fragile X syndrome (FXS) have not resulted in similar advances in clinical trials of humans with FXS due to the dearth of tools to quantify their key cognitive and behavioral outcome measures with optimal validity and reliability. Therefore, experts strongly recommended an effort to develop and implement use of biomarkers in unfolding clinical trials in FXS. Molecular imaging provides a spectrum of agents to serve as biomarkers to confirm that humans with FXS exhibit the molecular abnormalities of animal models of FXS. Thus, molecular imaging provides the mechanism to establish target engagement in humans for clinical trials of novel agents for FXS.

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“…As with MV individuals, challenges related to behavioral compliance and task comprehension constrain research in this population (e.g. Cox, Virues‐Ortega, Julio, & Martin, ); consequently, most neuroimaging research with this population has focused on assessing structural, rather than functional, atypicalities. To evaluate extant literature on structural neuroimaging studies of ASD + ID we conducted a PubMed search (July 29, 2016) using the following search terms: (‘intellectual disability’ OR ‘mental retardation’ OR ‘low functioning’) AND (autism OR pervasive developmental disorder) AND (mri OR dti OR dwi OR voxel based morphometry OR volumetric), or variants of these terms, with a species limiter of ‘humans’ (see Appendix S1).…”

Section: Intellectual Disabilitymentioning

confidence: 99%

Annual Research Review: Understudied populations within the autism spectrum – current trends and future directions in neuroimaging research

Jack

Pelphrey

2017

Child Psychology Psychiatry

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Background Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions that vary in both etiology and phenotypic expression. Expressions of ASD characterized by a more severe phenotype, including autism with intellectual disability (ASD+ID), autism with a history of developmental regression (ASD+R), and minimally verbal autism (ASD+MV) are understudied generally, and especially in the domain of neuroimaging. However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes. Scope and Methodology This review evaluates existing neuroimaging research on ASD+MV, ASD+ID, and ASD+R, identified by a search of the literature using the PubMed database, and discusses methodological, theoretical, and practical considerations for future research involving neuroimaging assessment of these populations. Findings There is a paucity of neuroimaging research on ASD+ID, ASD+MV, and ASD+R, and what findings do exist are often contradictory, or so sparse as to be ungeneralizable. We suggest that while greater sample sizes and more studies are necessary, more important would be a paradigm shift toward multimodal (e.g., imaging genetics) approaches that allow for the characterization of heterogeneity within etiologically diverse samples.

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Establishing motion control in children with autism and intellectual disability: Applications for anatomical and functional MRI

Cited by 52 publications

References 39 publications

Individualised MRI training for paediatric neuroimaging in autism spectrum disorders: A child-focused approach

Individualised MRI training for paediatric neuroimaging in autism spectrum disorders: A child-focused approach

The Urgent Need for Molecular Imaging to Confirm Target Engagement for Clinical Trials of Fragile X Syndrome and Other Subtypes of Autism Spectrum Disorder

Annual Research Review: Understudied populations within the autism spectrum – current trends and future directions in neuroimaging research

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