Establishing apomorphine treatment in Thailand: understanding the challenges and opportunities of Parkinson’s disease management in developing countries

Early factors for predicting discontinuation to subcutaneous Apomorphine infusion in Parkinson's disease: A prospective analysis of the Thai Apomorphine Registry

“…CSAI remains a proven add-on therapy for treating motor complications in patients with PD with good efficacy and tolerability found in both clinical studies and in clinical practice [1,6,10]. Compared to oral medications, CSAI is a relatively new treatment in Thailand, with increasing complexity throughout the course of treatment [6].…”

“…CSAI remains a proven add-on therapy for treating motor complications in patients with PD with good efficacy and tolerability found in both clinical studies and in clinical practice [1,6,10]. Compared to oral medications, CSAI is a relatively new treatment in Thailand, with increasing complexity throughout the course of treatment [6]. Recently, a study was published to assess the efficacy and outcomes of CSAI in Indian patients, providing retrospective insight on short-term efficacy of CSAI amongst an Asian population [11].…”

“…Observational studies have also reported long-term benefits of CSAI lasting up to 10 years following treatment [3][4][5]. Compared to other device-aided therapies, including levodopa-carbidopa intestinal gel infusion and deep brain stimulation, CSAI is the least invasive drug administration procedure and is easily reversible, whereas the other two options require further surgery for reversal [6]. Despite the growing evidence for CSAI benefits in PD, there are relatively few cohorts of Asian patients to demonstrate its efficacy in this population [7].…”

“…This Registry exclusively included patients undergoing CSAI as an add-on therapy. The main objective for establishing the registry was to collect patient information and other CSAIrelated outcomes to help neurologists determine whether appropriate healthcare services and assistance were accessible to patients with CSAI and their caregivers [6]. The data collection comprised of two periods (Fig.…”

The rise of Parkinson’s disease is a global challenge, but efforts to tackle this must begin at a national level: a protocol for national digital screening and “eat, move, sleep” lifestyle interventions to prevent or slow the rise of non-communicable diseases in Thailand

“…Thailand has a total population of almost 69 million and is served by 927 government hospitals, 363 private hospitals, and 9,768 primary health care units with 99.5% of the population having health protection coverage ( 27 ). However, with a large proportion of the population living in poorer rural areas of the country, previous experience has identified considerable challenges in terms of healthcare delivery to such a diverse population, particularly where resources and access to specialists expertise may be limited ( 28 ).…”