Establishing and validating a prognostic model for colorectal cancer patients by integrating data from single-cell RNA sequencing and bulk RNA sequencing
Qiujin Huang,
Dengwei You,
Zhi Huang
et al.
Abstract:Background
Colorectal adenocarcinoma (COAD) is a major global cause of mortality. While conventional RNA sequencing (RNA-seq) has been used to study its prognostic indicators, it lacks precision in identifying cellular alterations. This study aimed to develop a predictive framework for COAD by integrating scRNA-seq with conventional RNA-seq.
Methods
This study acquired primary RNA sequencing data from The Cancer Genome Atlas (TCGA) database and single-cell RNA sequencing data on colorectal adenocarcinoma (COAD… Show more
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