Establishing an Artificial Pathway for the Biosynthesis of Octopamine and Synephrine
Jiao Feng,
Runyuan Jin,
Shasha Cheng
et al.
Abstract:In
this study, we designed an artificial pathway composed of tyramine
β-hydroxylase (TBH) and phenylethanolamine N-methyltransferase (PNMT) for the biosynthesis of both octopamine
and synephrine. As most TBH and PNMT originate from eukaryotic animals
and plants, the heterologous expression and identification of functional
TBH and PNMT are critical for establishing the pathway in mode microorganisms
like Escherichia coli. Here, three
TBHs were evaluated, and only TBH from Drosophila melanogaster was successfull… Show more
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