Establishing Amyloid PET Imaging Biomarkers: Ongoing Efforts

Optimizing Longitudinal Amyloid-β PET Measurement: The Challenges of Intensity Normalization

“…Cross-sectional Ab PET analyses have frequently used the cerebellar cortex or the whole cerebellum (white plus gray matter) because these regions are known to be relatively free of Ab in AD. Few studies have compared PET SUVRs calculated using different regions with one another, but existing work suggests that different reference regions are far from interchangeable (7,8). For example, longitudinal florbetapir PET cortical SUVRs calculated using a whole cerebellum reference region are only minimally predictive of the same cortical change calculated using a white matter (WM) reference region (9).…”