Establishing a Standard of Care for Small Bowel Adenocarcinomas: Challenges and Lessons Learned

Halfdanarson, Thorvardur R.; Grothey, Axel

doi:10.1634/theoncologist.2012-0323

Cited by 1 publication

(3 citation statements)

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“…Systemic treatment in metastatic SBA is based on adjuvant chemotherapy with the combination of fluoropyrimidine (i.e. 5-fluorouracyl or capecytabine) and oxaliplatin as supported by promising outcomes found recently in a few retrospective clinical studies [1,10]. It transpires that the protocol used for treating colorectal adenocarcinoma has shown a survival benefit for SBA patients.…”

Section: Discussionmentioning

confidence: 99%

“…Duodenal SBA appears to have a worse prognosis than jejunal or ileal SBA but the reason is unexplained. It may be assumed that incomplete lymph node resection at surgery and misclassifying some patients suffering from adenocarcinoma of the ampulla of Vater as having duodenal SBA could explain this finding; ampullary cancer should be treated with gemcitabine-based regimens [10,14].…”

Section: Discussionmentioning

confidence: 99%

“…A handful of case reports have also described responses to anti-EGFR therapy in SBA patients with KRAS wild-type tumours [1,5,15]. The SBA treatment protocol is nevertheless still vague, mainly due to the low prevalence of SBA and too few prospective clinical trials [10]. WBC -white blood cell count; RBC -red blood cell count; PLT -platelets; CRP -C reactive protein; Hgb -hemoglobin…”

Section: Discussionmentioning

confidence: 99%

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Small bowel adenocarcinoma (SBA) — a case report

Polczyk

2017

Nowotwory. Journal of Oncology

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Backround. Small bowel cancers account for less than 0.5% of all malignancies and approximately 1-3% of gastrointestinal tract malignancies. The two major tumour types are carcinoid and adenocarcinoma. The latter is most commonly found in the duodenum and jejunum, but least often in the ileum. Case presentation. We present a case study of a 67-year-old woman with small bowel adenocarcinoma (SBA) of the ileum. The patient was admitted to the hospital with nonspecific, persistent, recurrent pain in her upper abdomen and with suspected subileus. Previously performed clinical investigation (i.e. colonoscopy, computed tomography scans -CT scans, small bowel follow-through) didn't reveal any abnormalities. At laparotomy we discovered a round mass obstructing the ileal lumen at about 40 cm from the Bauhin valve. A tumour was then resected within its surgical margins. Pathologic examination revealed an ileal adenocarcinoma and an infiltration of the local adipose tissue (Adenocarcinoma G3 partim gelatinosum), with no evidence of metastatic lesions in the lymph nodes nor into other organs (pT3N0M0; the clinical stage IIA). Further oncological treatment was thereby advised. Conclusions. A low prevalence and non-specific symptoms along without any clearly established diagnostic nor treatment protocols makes a final diagnosis difficult and thus merits further diagnostic investigation, particularly the testing of specific biochemical or immunological markers. NOWOTWORY J Oncol 2017; 67, 2: 137-141

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%