2020
DOI: 10.4269/ajtmh.20-0833
|View full text |Cite
|
Sign up to set email alerts
|

Establishing a National Molecular Surveillance Program for the Detection of Plasmodium falciparum Markers of Resistance to Antimalarial Drugs in Haiti

Abstract: Chloroquine remains the first-line treatment for uncomplicated malaria in Haiti, and until recently, sulfadoxine-pyrimethamine was the second-line treatment. A few studies have reported the presence of molecular markers for resistance in Plasmodium falciparum parasites, and in vivo therapeutic efficacy studies (TESs) have been limited. Recognizing the history of antimalarial resistance around the globe and the challenges of implementing TESs in low-endemic areas, the Ministry of Health established a surveillan… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
5
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 6 publications
(6 citation statements)
references
References 27 publications
0
5
0
Order By: Relevance
“…Low and moderate transmission settings have started implementing centralized genomic surveillance. For instance, Haiti [ 90 ], Honduras [ 91 ] and South Africa [ 28 ] provide examples of national molecular surveillance, while the GenRe-Mekong study provides a model for regional surveillance [ 92 ]. However, a feasibility study and cost-effectiveness analysis may be needed to inform the relevance of such a system in high malaria transmission settings.…”
Section: Discussionmentioning
confidence: 99%
“…Low and moderate transmission settings have started implementing centralized genomic surveillance. For instance, Haiti [ 90 ], Honduras [ 91 ] and South Africa [ 28 ] provide examples of national molecular surveillance, while the GenRe-Mekong study provides a model for regional surveillance [ 92 ]. However, a feasibility study and cost-effectiveness analysis may be needed to inform the relevance of such a system in high malaria transmission settings.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, there are six countries in the Americas that still use chloroquine and primaquine as first-line of treatment against uncomplicated P. falciparum malaria: Guatemala, Honduras, Nicaragua, Costa Rica, Haiti, and the Dominican Republic [ 1 ]. Given the imminent threat of the spontaneous appearance of mutant parasite strains due to drug exerted pressure, as well as increasing human migration to North America through the Central American isthmus [ 24 , 25 ], it is important to periodically monitor parasite populations for evidence of CQR [ 26 ]. This study is an effort to contribute to the routine surveillance of CQR in P. falciparum that has been carried out in Central America since 2010.…”
Section: Discussionmentioning
confidence: 99%
“…: Guatemala, Honduras, Nicaragua, Costa Rica, Haiti, and the Dominican Republic [1]. Given the imminent threat of the spontaneous appearance of mutant parasite strains due to drug exerted pressure, as well as increasing human migration to North America through the Central American isthmus, it is important to periodically monitor parasite populations for evidence of CQR [20,21]. This study is an effort to contribute to the routine surveillance of CQR in P. falciparum that has been carried out in Central America since 2010.…”
Section: Discussionmentioning
confidence: 99%