“…1948), studies of bedrest (Birkhead et al, 1963;Miller et al, 1964aMiller et al, , 1964b, the effects of confinement in special rooms (Alluisi et al, 1963;Hanna et al, 1963;Lebedinsky et al, 1964). Perhaps more closely related to space missions have been studies of submarine confinement (Fawcett and Newman, 1953;Weybrew, 1963) and in space-cabin simulators (Celentano et al, 1963;Lawton et al, 1964;Grodsky and Bryant, 1962;Hanna, 1962;. More recently, some longer space-cabin simulations have been conducted, including the 56-day exposure to an oxygen-helium environment in the USAF School of Aerospace Medicine environmental simulator (Hargreaves et al, 1966), and the 60-and 90-day closed-loop system manned simulations conducted by the McDonnell Douglas Astronautics Company (Taliaferro and Seaman, 1969;McDonnell Douglas, 1971).…”