Establishing a combined optogenetic-electrophysiological method to characterize the activity of granule cells in the dentate gyrus of freely moving mice
Abstract:Efforts to understand the role of the dentate gyrus have been hampered by the limitation of extracellular recordings to identify cell types. By combining extracellular recording with optogenetics, it has become possible to identify and characterize the activity of specific cell types. Here, we assessed the feasibility of this technique to identify granule cells of the dentate gyrus in freely behaving mice. We were able to detect units that responded to light stimulation with short latency and high reliability.… Show more
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