Abstract:Transient receptor potential cation channel subfamily V (TRPV4) is a widely expressed multimodal gated ion channel that transports Ca2+ intracellularly upon opening and plays an important role in many physiological and pathological processes. However, existing TRPV4 channel regulators lack specificity and are ineffective, and available screening methods are not suitable for high-throughput screening of regulators. Therefore, in this study, we developed a cellular model and method for high-throughput drug scree… Show more
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