Essential tremor prevalence is low in Arabic villages in Israel

Inzelberg, Rivka; Mazarib, Aziz; Masarwa, Magda; Abuful, Amin; Strugatsky, Rosa; Friedland, Robert

doi:10.1007/s00415-006-0253-5

Cited by 33 publications

(37 citation statements)

References 9 publications

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“…The WHIGET diagnostic criteria for ET were developed for a population-based genetic study and, based on data from approximately 2,000 normals (non-diseased controls), these criteria carefully indicate the specific examination maneuvers during which tremor should be present and the severity of tremor that should be evident during these maneuvers. These criteria have been shown to be reliable [16] and valid [18], and are used routinely in Dr. Louis’ epidemiological studies of ET [20, 21] and those of other tremor investigators in the US and internationally [22, 23]. The diagnosis of PD was confirmed (E.D.L.)…”

Section: Methodsmentioning

confidence: 99%

Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients

Louis

Machado

2015

Parkinsonism & Related Disorders

104

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Background Tremor-related quality of life is a multi-dimensional concept that reflects the physical, emotional and other health effects of tremor. Curiously, tremor-related quality of life has never been directly compared in patients with the two major tremor disorders, essential tremor (ET) and Parkinson’s disease (PD). We performed a head-to-head comparison of ET with PD patients. Methods The Quality of Life in Essential Tremor (QUEST) questionnaire was administered to 103 ET and 103 matched PD patients enrolled in a clinical-epidemiological study in New York. Results The QUEST total score and QUEST physical subscore were higher in ET than PD patients (both p<0.05). In relative terms, ET patients reported significantly more impairment than PD patients in multiple areas; PD patients reported more impairment than ET patients in one area (all p≤0.02). In absolute terms, tremor impacted on many aspects of quality of life in both diseases, including physical and psychosocial, and in one-third or more of PD patients, tremor sometimes, frequently or always interfered with numerous physical activities, including writing, using a typewriter/computer, fixing small things, dressing, eating, and holding reading material. Conclusions Tremor is a clinical entity that can have numerous effects on patients. While there were relative differences between the two major tremor disorders, ET and PD, in absolute terms, tremor impacted on several domains of quality of life, from physical to psychosocial, in a large proportion of ET and PD patients. Attempts to judge the efficacy of treatments for tremor, whether pharmacological or surgical, should consider its broad impact.

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Section: Methodsmentioning

confidence: 99%

Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients

Louis

Machado

2015

Parkinsonism & Related Disorders

104

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“…using the videotaped neurological examination and WHIGET diagnostic criteria (moderate or greater amplitude kinetic tremor [tremor rating 2] during three or more tests or a head tremor, in the absence of Parkinson’s disease, dystonia or another cause) [30]. These criteria have been shown to be reliable [27] and valid [29], and are used routinely in clinical and epidemiological studies of ET [22, 31–33]. …”

Section: Methodsmentioning

confidence: 99%

Self-reported physical activity in essential tremor: Relationship with tremor, balance, and cognitive function

Louis

Collins

Rohl

et al. 2016

Journal of the Neurological Sciences

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Background Physical inactivity may be the result of medical comorbidities. Inactivity itself may also lead to important health consequences, especially in older patients. Essential tremor (ET) patients may have a variety of physical and cognitive problems that could detrimentally impact on level of physical activity. Yet, to our knowledge, there have been no studies of physical activity in these patients. Methods Self-reported physical activity was assessed using the Physical Activity Scale for the Elderly (PASE) in 100 ET cases (mean age 80.5 years) enrolled in a clinical study. Additional clinical measures were the total tremor score, Montreal Cognitive Assessment (MOCA) score and number of steps taken off of the straight line during tandem gait (a measure of balance). Results Lower PASE score was associated with older age, more tandem gait difficulty, higher total tremor score and lower MOCA score (all p<0.05). In a linear regression model that included total tremor score, MOCA score, number of steps off of the straight line during tandem gait, and age, higher total tremor score (p = 0.046) and more steps off of the straight line during tandem gait (p = 0.014) were independently associated with reductions in physical activity. Conclusions Several of the motor features of ET (tremor and imbalance) are independently associated with reductions in level of physical activity.

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“…First, the sample size in this population-based study is large, with data on 1,328 individuals, which corresponds to 5.5% of the entire Faroese population ≥40 years. More importantly, however, is that, tremor was (1) systematically quantified (2) by a senior movement disorder neurologist with particular specialization in tremor (3) using a reliable and valid clinical rating scale (4) followed by the application of rigorous diagnostic criteria used by tremor investigators in the United States and internationally [28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

“…These diagnostic criteria for ET were developed for a population-based genetic study and based on data from approximately 2,000 normal (nondiseased controls) [25], the criteria carefully specify the specific examination maneuvers during which tremor should be present and the severity of tremor that should be evident during these maneuvers to distinguish normal from ET. These criteria have been shown to be both reliable [26] and valid [27] and have been used by tremor investigators in the United States and internationally [28][29][30][31][32][33][34][35][36][37][38][39]. As in prior reports, borderline tremor was a diagnosis assigned to individuals who did not fully meet strict diagnostic criteria for ET (defined above) but were nonetheless considered by E.D.L.…”

Section: Diagnosis Of Et and Other Neurological Conditionsmentioning

confidence: 99%

Prevalence of Essential Tremor in the Faroe Islands: A Population-Based Study

et al. 2019

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Background: No studies of the prevalence of one of the most common movement disorders, essential tremor (ET), have been undertaken in the Faroe Islands. Given the potential for founder effects in the Islands, and the highly genetic nature of ET, the Faroe Islands provide a particularly interesting setting in which to study the prevalence of ET. Objective: To estimate the prevalence of ET and study its characteristics. Methods: We used a 2-phase, population-based design, screening 1,328 randomly selected Faroese individuals aged ≥40 years. A subsample of 282 individuals who had returned the spirals and questionnaire was selected to participate in an in-person clinical evaluation. Tremor was systematically quantified by a senior movement disorder neurologist with particular specialization in tremor using a reliable and valid clinical rating scale followed by the application of rigorous diagnostic criteria used by tremor investigators internationally. Results: The overall crude prevalence was 2.9%. The age-adjusted prevalence was 3.1%. There was an age-associated rise in prevalence; by age ≥70, prevalence reached 4.8%. Twenty six of 27 (96.2%) were previously undiagnosed. Conclusions: This is the first population-based study of the prevalence of ET in the Faroe Islands. The estimated prevalence was similar to studies using the same or comparable methodologies.

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Essential tremor prevalence is low in Arabic villages in Israel

Abstract: The prevalence of ET in Arabic villages of Wadi Ara is low.

Cited by 33 publications

References 9 publications

Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients

Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients

Self-reported physical activity in essential tremor: Relationship with tremor, balance, and cognitive function

Prevalence of Essential Tremor in the Faroe Islands: A Population-Based Study

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