Essential thrombocytosis and liver transplantation

Au, WY; Liu, C.L.; Lo, Chung‐Mau; Fan, Sheung‐Tat; Ma, S.K.

doi:10.1002/ajh.10275

Cited by 2 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is further compounded by the post-splenectomy thrombocytosis in case two, which however, seldom reach such profound levels after LT [9]. The abrupt rise in platelet counts, absence of basophilia and hepatic hematopoesis made primary myeloproliferative disease unlikely [10].…”

Section: Discussionmentioning

confidence: 99%

Potential role for platelet apheresis for post‐liver transplant thrombocytosis complicating portal vein thrombosis

Liu

et al. 2004

J of Clinical Apheresis

Self Cite

View full text Add to dashboard Cite

Except for patients with underlying myeloproliferative diseases (MPD), thrombocytosis is rarely encountered in cirrhotic patients after liver transplantation. Although the long-term control of primary thrombocytosis is important for the prevention of graft thrombosis in MPD patients, the threshold for intervention and best mode for the control of persistent reactive thrombocytosis after liver transplantation is unclear. We present two patients with extreme reactive thrombocytosis (over 1,000 x 10(9)/l) due to intra-abdominal sepsis after liver transplantation. Furthermore, both patients suffered from bleeding problems as well as ongoing venous thrombosis of the graft. Rapid control of the platelet count was achieved using platelet apheresis. The use of cell separation procedures may be a relatively rapid, reversible, and reasonably safe way to control platelet counts peri-operatively in liver transplant recipients.

show abstract

Section: Discussionmentioning

confidence: 99%

Potential role for platelet apheresis for post‐liver transplant thrombocytosis complicating portal vein thrombosis

Liu

et al. 2004

J of Clinical Apheresis

Self Cite

View full text Add to dashboard Cite

show abstract

“…JAK2 mutation was detected by allele-specific polymerase chain reaction (PCR), using mutant-specific primer (MF: 5 0 -AGC ATT TGG TTT TAA ATT ATG GAG TAT ATT-3 0 ), an internal control primer (ICF: 5 0 -ATC TAT AGT CAT GCT GAA AGT AGG AGA AAG-3 0 ), and a reverse primer (R: 5 0 -CTG AAT AGT CCT ACA GTG TTT TCA GTT TCA-3 0 ) [2]. The PCR mixture contained 0.2 mM dNTP, 1 mmol/L primer R, 0.5 mmol/L of primers MF and ICF, 50 ng DNA template, 2.0 mM MgCl 2 , 1Â PCR buffer, and 1 U AmpliTaq DNA polymerase (Applied Biosystem, Foster City, CA, USA) in a total volume of 25 mL.…”

Section: Molecular Analysismentioning

confidence: 99%

Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation

Fung

Liu

et al. 2006

Am. J. Hematol.

Self Cite

View full text Add to dashboard Cite

A 52-year-old man developed essential thrombocythemia (ET) with JAK2 V617F mutation after orthotopic liver transplantation (OLT). Retrospective analysis showed that, despite a low platelet count, the JAK2 mutation was already found at presentation 14 months before OLT. The high platelet count that would have been typical of ET might be masked by the cirrhosis-related hypersplenism. Thrombocythemia became obvious after OLT. The patient subsequently developed blastic transformation 12 months afterward, a process probably accelerated by the immunosuppression required for the OLT.

show abstract

Essential thrombocytosis and liver transplantation

Cited by 2 publications

References 6 publications

Potential role for platelet apheresis for post‐liver transplant thrombocytosis complicating portal vein thrombosis

Potential role for platelet apheresis for post‐liver transplant thrombocytosis complicating portal vein thrombosis

Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation

Contact Info

Product

Resources

About