“…58,63 The recent study by Vaghi et al (2012) investigating Rac1 and the neural specific Rac3 in the development of cortical and hippocampal GABAergic neurons suggests that both Rac1 and Rac3 contribute synergistically to the regulation of cortical and hippocampal neuronal migration and differentiation, which may explain the epileptic phenotype of the Rac1/Rac3 double mutant mice. 64,65 Lastly, several defects were also observed in the development of the cerebellum lacking Rac1. 66 Taken together, these studies clearly establish fundamental roles of RhoA, Rac1, and Cdc42 during early development of the CNS.…”