Essential Role of Histone Replacement and Modifications in Male Fertility

Wang, Tong; Gao, Hui; Li, Wei; Liu, Chao

doi:10.3389/fgene.2019.00962

Cited by 105 publications

(91 citation statements)

References 147 publications

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“…Histones are widely replaced from the sperm genome and depending of the analyzed specie, the rate of retention varies. As we will describe below, it seems that histone replacement in the sperm genome has become a more understood mechanism (broadly reviewed in Bao and Bedford, 2016;Wang et al, 2019), whereas a nucleosome retention mechanism is still at large.…”

Section: Histone Replacement In the Sperm Genomementioning

confidence: 99%

The Interplay Between Replacement and Retention of Histones in the Sperm Genome

Torres-Flores

Hernández‐Hernández

2020

Front. Genet.

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The genome of eukaryotes is highly organized within the cell nucleus, this organization per se elicits gene regulation and favors other mechanisms like cell memory throughout histones and their post-translational modifications. In highly specialized cells, like sperm, the genome is mostly organized by protamines, yet a significant portion of it remains organized by histones. This protamine-histone-DNA organization, known as sperm epigenome, is established during spermiogenesis. Specific histones and their posttranslational modifications are retained at specific genomic sites and during embryo development these sites recapitulate their histone profile that harbored in the sperm nucleus. It is known that histones are the conduit of epigenetic memory from cell to cell, hence histones in the sperm epigenome may have a role in transmitting epigenetic memory from the sperm to the embryo. However, the exact function and mechanism of histone retention remains elusive. During spermatogenesis, most of the histones that organize the genome are replaced by protamines and their retention at specific regions may be deeply intertwined with the eviction and replacement mechanism. In this review we will cover some relevant aspects of histone replacement that in turn may help us to contextualize histone retention. In the end, we focus on the architectonical protein CTCF that is, so far, the only factor that has been directly linked to the histone retention process.

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Section: Histone Replacement In the Sperm Genomementioning

confidence: 99%

The Interplay Between Replacement and Retention of Histones in the Sperm Genome

Torres-Flores

Hernández‐Hernández

2020

Front. Genet.

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“…As mentioned in previous literature, a nucleotide variation by demolishing or generating a connection in the regulatory gene network may activate or inhibit the expression of target genes (Wang & Batmanov, 2015). Additionally, the cDNA.42G>A variation was detected as a promoter-associated region and generally had regulatory features such as H3K27ac and H3K36me3, which it has been authenticated that H3 contributes to the PRM1 incorporation (Kouzmenko et al, 2019). Also, Tong et al, handled a study on mice cell line and through enriching spermatocytes and round spermatids, indicated H3K36me3 regulate the TNPs and PRMs genes expression (Tong, 2018).…”

Section: Ta B L Ementioning

confidence: 65%

Identification of thePRM1gene mutations in oligoasthenoteratozoospermic men

et al. 2020

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Mutations or altered expression of PRM1 gene have been associated with male infertility. This study aimed to analyse pathogenic variations of PRM1 gene in Iranian Arab infertile men with oligoasthenoteratozoospermia that was carried out for the first time in this population. Genomic DNA was used to perform PCR sequencing in PRM1 untranslated regions, exons and intron. Also, bioinformatics analysis was recruited to discover the possible effect of detected variations. Two pathogenic variations were seen in two men with oligoasthenoteratozoospermia, which were not found in the control group. The cDNA.384G>C variation is novel and was located in the 3′ untranslated region, and cDNA.42G>A variation is reported for the first time related to male infertility and was found in 5′ untranslated regions. Bioinformatics analysis showed that the minimum free energy was increased from −19.9kcal/mol to −13.1kcal/mol due to the cDNA.384G>C variation at hsa‐miR‐4326's seed site. More analysis revealed cDNA.42G>A located in transcription factors binding site, E1 and MYOD, which was detected as a promoter‐associated region, and generally have regulatory features for acetylation and methylation. In conclusion, two pathogenic variations were recognised in regulatory areas of PRM1 gene, which might interfere with some critical factors related to PRM1 gene expression, hence cause male infertility.

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“…In particular, an unusually high abundance of histone variants has been identified as an epigenetic error contributing to failed embryo development [ 134 ]. Beyond histone variants, the complex picture of histone modifications has also been described as an important quality marker of sperm, as recently reviewed [ 74 , 135 ].…”

Section: Epigenetic Signature Of Male Germlinementioning

confidence: 99%

Environmental Impact on Male (In)Fertility via Epigenetic Route

Cescon

Chianese

Tavares

2020

JCM

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In the last 40 years, male reproductive health—which is very sensitive to both environmental exposure and metabolic status—has deteriorated and the poor sperm quality observed has been suggested to affect offspring development and its health in adult life. In this scenario, evidence now suggests that epigenetics shapes endocrine functions, linking genetics and environment. During fertilization, spermatozoa share with the oocyte their epigenome, along with their haploid genome, in order to orchestrate embryo development. The epigenetic signature of spermatozoa is the result of a dynamic modulation of the epigenetic marks occurring, firstly, in the testis—during germ cell progression—then, along the epididymis, where spermatozoa still receive molecules, conveyed by epididymosomes. Paternal lifestyle, including nutrition and exposure to hazardous substances, alters the phenotype of the next generations, through the remodeling of a sperm epigenetic blueprint that dynamically reacts to a wide range of environmental and lifestyle stressors. With that in mind, this review will summarize and discuss insights into germline epigenetic plasticity caused by environmental stimuli and diet and how spermatozoa may be carriers of induced epimutations across generations through a mechanism known as paternal transgenerational epigenetic inheritance.

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Essential Role of Histone Replacement and Modifications in Male Fertility

Cited by 105 publications

References 147 publications

The Interplay Between Replacement and Retention of Histones in the Sperm Genome

The Interplay Between Replacement and Retention of Histones in the Sperm Genome

Identification of thePRM1gene mutations in oligoasthenoteratozoospermic men

Environmental Impact on Male (In)Fertility via Epigenetic Route

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