Essential Role of Anisotropy in Bioengineered Cardiac Tissue Models
Aditi Jain,
Saswat Choudhury,
Nagalingam R. Sundaresan
et al.
Abstract:As regulatory bodies encourage alternatives to animal testing, there is renewed interest in engineering disease models, particularly for cardiac tissues. The aligned organization of cells in the mammalian heart controls the electrical and ionic currents and its ability to efficiently circulate blood to the body. Although the development of engineered cardiac systems is rising, insights into the topographical aspects, in particular, the necessity to design in vitro cardiac models incorporating cues for unidirec… Show more
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