Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination

Dowdell, Alexander S.; Cartwright, Ian M.; Kitzenberg, David; Kostelecky, Rachael; Mahjoob, Omemh; Saeedi, Bejan; Welch, Nichole; Glover, Louise; Colgan, Sean P.

doi:10.1016/j.celrep.2022.111409

Cited by 7 publications

(4 citation statements)

References 105 publications

(143 reference statements)

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“…In this study, L. lactis KLDS 4.0325 combined with heme significantly increased the expression level of LC3 in mice and activated autophagy of body cells. Dowdell et al [72] found that consuming intestinal oxygen can stabilize hypoxia-inducible factor HIF and induce autophagy, thereby limiting the transmission of S. Typhimurium and inhibiting inflammation. This indicates that the correlation among intestinal oxygen concentration, HIF and intestinal cell autophagy may effectively inhibit intracellular pathogenic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Aerobic respiration Lactococcus lactis ameliorate Salmonella induced infection and intestinal dysfunctions by oxygen-scavenging and maintaining immune balance and regulating intestinal microbiota

Zhang,

Yang,

Cheng

et al. 2024

Food Science and Human Wellness

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Section: Discussionmentioning

confidence: 99%

Aerobic respiration Lactococcus lactis ameliorate Salmonella induced infection and intestinal dysfunctions by oxygen-scavenging and maintaining immune balance and regulating intestinal microbiota

Zhang,

Yang,

Cheng

et al. 2024

Food Science and Human Wellness

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“…It has been demonstrated that increased xenophagy helps to protect the host against infection. For example, hypoxia-inducible factor (HIF-1) is a mediator to activate xenophagy and limit salmonella infection and spread 21 . Resveratrol also activates xenophagy and promotes intracellular bacteria clearance in intestinal epithelial cells and macrophages 77 .…”

Section: Selective Autophagy Modulators and Receptors In Human Diseasesmentioning

confidence: 99%

“…There are various terms to describe diverse selective autophagy according to different autophagic substrates: mitophagy [6], ER-phagy [7], aggrephagy [8], lipophagy [9], xenophagy [10], nucleophagy [11], pexophagy [12], ferritinophagy [13], lysophagy [14] and fluidophagy [15]. Studies have revealed that selective autophagy is implicated in various human diseases such as cancers, neurodegenerative diseases, and infectious diseases [16][17][18][19][20][21][22]. For example, impaired mitophagy has been observed in Alzheimer's disease (AD) models with the downregulation of BCL2 interacting protein 3 (BNIP3), fun14 domain containing 1 (FUNDC1), and optineurin (OPTN) [16,17].…”

Section: Introductionmentioning

confidence: 99%

Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies

Wu,

Li,

2024

Int. J. Biol. Sci.

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Autophagy is a highly conserved physiological process that maintains cellular homeostasis by recycling cellular contents. Selective autophagy is based on the specificity of cargo recognition and has been implicated in various human diseases, including neurodegenerative diseases and cancer. Selective autophagy receptors and modulators play key roles in this process. Identifying these receptors and modulators and their roles is critical for understanding the machinery and physiological function of selective autophagy and providing therapeutic value for diseases. Using modern researching tools and novel screening technologies, an increasing number of selective autophagy receptors and modulators have been identified. A variety of Strategies and approaches, including protein-protein interactions (PPIs)-based identification and genome-wide screening, have been used to identify selective autophagy receptors and modulators. Understanding the strengths and challenges of these approaches not only promotes the discovery of even more such receptors and modulators but also provides a useful reference for the identification of regulatory proteins or genes involved in other cellular mechanisms. In this review, we summarize the functions, disease association, and identification strategies of selective autophagy receptors and modulators.

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“…HIF-1α activation correlates with protection against intestinal inflammation during bacterial infections and in a chemically-induced colitis model [ 108 , 109 , 110 , 111 ]. Thus, Salmonella infection leads to stabilization and activation of HIF-1α in epithelial cells which is associated with a protective immune response [ 110 , 112 ]. Proinflammatory cytokines IL-1β and IL-23 upregulate the expression of HIF-1α in ILC3s [ 113 ].…”

Section: Role Of Intestinal Hypoxia In Ilc Plasticitymentioning

confidence: 99%

Innate Lymphoid Cell Plasticity in Mucosal Infections

2023

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Mucosal tissue homeostasis is a dynamic process that involves multiple mechanisms including regulation of innate lymphoid cells (ILCs). ILCs are mostly tissue-resident cells which are critical for tissue homeostasis and immune response against pathogens. ILCs can sense environmental changes and rapidly respond by producing effector cytokines to limit pathogen spread and initiate tissue recovery. However, dysregulation of ILCs can also lead to immunopathology. Accumulating evidence suggests that ILCs are dynamic population that can change their phenotype and functions under rapidly changing tissue microenvironment. However, the significance of ILC plasticity in response to pathogens remains poorly understood. Therefore, in this review, we discuss recent advances in understanding the mechanisms regulating ILC plasticity in response to intestinal, respiratory and genital tract pathogens. Key transcription factors and lineage-guiding cytokines regulate this plasticity. Additionally, we discuss the emerging data on the role of tissue microenvironment, gut microbiota, and hypoxia in ILC plasticity in response to mucosal pathogens. The identification of new pathways and molecular mechanisms that control functions and plasticity of ILCs could uncover more specific and effective therapeutic targets for infectious and autoimmune diseases where ILCs become dysregulated.

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Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination

Cited by 7 publications

References 105 publications

Aerobic respiration Lactococcus lactis ameliorate Salmonella induced infection and intestinal dysfunctions by oxygen-scavenging and maintaining immune balance and regulating intestinal microbiota

Aerobic respiration Lactococcus lactis ameliorate Salmonella induced infection and intestinal dysfunctions by oxygen-scavenging and maintaining immune balance and regulating intestinal microbiota

Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies

Innate Lymphoid Cell Plasticity in Mucosal Infections

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