Essential Oils of <i>Cedrus deodara</i> Leaves Exerting Anti-inflammation on TPA-induced Ear Edema by Inhibiting COX-2/TNF-α/NF-κB Activation

Chen, Yu; Chi, Lejing; Liang, Xinmiao; Shi, Yaohui; Wu, Tongyun; Ye, Mao; Han, Ping; Lin, Li; Zhang, Lanyue; Xu, Peng; Du, Zhiyun

doi:10.1080/0972060x.2020.1756427

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…The C. deodara wood EO apparently inhibits enzymes involved in drug metabolism; it is devoid of any analgesic or sedative properties [ 227 ]. An EO obtained from the “dried rhizome” of C. deodara exhibited antiinflammatory effects in an auricle swelling murine model by inhibiting the expression of NF-kB, TNFα, and COX-2 [ 229 ]. A wood EO of C. deodara administered orally demonstrated antiinflammatory and analgesic activities in rat models (carrageenan-induced paw edema, acetic acid writhing test, and hot plate test—at 50 and 100 mg/kg body weight) [ 230 ].…”

Section: Pharmacological Interest Of Pinaceae Eosmentioning

confidence: 99%

Antioxidant Activity of Essential Oils from Pinaceae Species

Ancuceanu,

Anghel,

Hovaneț

et al. 2024

Antioxidants

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With a widespread distribution throughout the Northern Hemisphere and 11 genera, Pinaceae is the largest family of Gymnosperms in the world. Essential oils are an important chemotaxonomic marker for the species of this family, although the degree of chemical and biological investigation has not been the same for all genera. Essential oils from Abies and Cedrus (from the abietoid clade) or Pinus and Picea (from the pinoid clade) have been more extensively investigated with respect to their chemical composition and biological or pharmacological properties, including their antioxidant effects. Instead, essential oils from the other genera of the family have been less explored in this respect or even have not been investigated at all. This is a narrative review looking into the knowledge acquired up to date, the variability and limitations of the current methods used to estimate antioxidant effects, and multiple comparisons between EOs obtained from different genera, species, and plant parts, as well as potential applications and future directions of research and utilization of essential oils derived from Pinaceae species.

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Section: Pharmacological Interest Of Pinaceae Eosmentioning

confidence: 99%

Antioxidant Activity of Essential Oils from Pinaceae Species

Ancuceanu,

Anghel,

Hovaneț

et al. 2024

Antioxidants

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“…Additionally, some reports indicated that extracts from other Cedrus species, particularly Cedrus deodara, Cedrus libani, and Cedrus brevifolia, exert in vitro and in vivo anti-inflammatory action by inhibiting COX-2/TNF-α/NF-κB activation, repressing the lipoxygenase activity, and preventing linoleic acid and lipid peroxidation [48][49][50][51].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Antioxidant, Volatile Compounds; Antimicrobial, Anti-Inflammatory, and Dermatoprotective Properties of Cedrus atlantica (Endl.) Manetti Ex Carriere Essential Oil: In Vitro and In Silico Investigations

et al. 2023

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Cedrus atlantica (Endl.) Manetti ex Carriere is an endemic tree possessing valuable health benefits which has been widely used since time immemorial in international traditional pharmacopoeia. The aim of this exploratory investigation is to determine the volatile compounds of C. atlantica essential oils (CAEOs) and to examine their in vitro antimicrobial, antioxidant, anti-inflammatory, and dermatoprotective properties. In silico simulations, including molecular docking and pharmacokinetics absorption, distribution, metabolism, excretion, and toxicity (ADMET), and drug-likeness prediction were used to reveal the processes underlying in vitro biological properties. Gas chromatography–mass spectrophotometry (GC-MS) was used for the chemical screening of CAEO. The antioxidant activity of CAEO was investigated using four in vitro complementary techniques, including ABTS and DPPH radicals scavenging activity, ferric reductive power, and inhibition of lipid peroxidation (β-carotene test). Lipoxygenase (5-LOX) inhibition and tyrosinase inhibitory assays were used for testing the anti-inflammatory and dermatoprotective properties. GC-MS analysis indicated that the main components of CAEO are β-himachalene (28.99%), α-himachalene (14.43%), and longifolene (12.2%). An in vitro antimicrobial activity of CAEO was examined against eleven strains of Gram-positive bacteria (three strains), Gram-negative bacteria (four strains), and fungi (four strains). The results demonstrated high antibacterial and antifungal activity against ten of them (>15 mm zone of inhibition) using the disc-diffusion assay. The microdilution test showed that the lowest values of MIC and MBC were recorded with the Gram-positive bacteria in particular, which ranged from 0.0625 to 0.25 % v/v for MIC and from 0.5 to 0.125 % v/v for MBC. The MIC and MFC of the fungal strains ranged from 0.5 to 4.0% (MIC) and 0.5 to 8.0% v/v (MFC). According to the MBC/MIC and MFC/MIC ratios, CAEO has bactericidal and fungicidal activity. The results of the in vitro antioxidant assays revealed that CAEO possesses remarkable antioxidant activity. The inhibitory effects on 5-LOX and tyrosinase enzymes was also significant (p < 0.05). ADMET investigation suggests that the main compounds of CAEO possess favorable pharmacokinetic properties. These findings provide scientific validation of the traditional uses of this plant and suggest its potential application as natural drugs.

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