Essential Oils of Hyptis pectinata Chemotypes: Isolation, Binary Mixtures and Acute Toxicity on Leaf-Cutting Ants

Feitosa-Alcantara, Rosana Barroso; Bacci, Leandro; Blank, Arie Fitzgerald; Alves, Péricles Barreto; Silva, Indira Morgana de Araújo; Soares, Caroline Alves; Sampaio, Taís Santos; Nogueira, Paulo César de Lima; Arrigoni-Blank, Maria de Fátima

doi:10.3390/molecules22040621

Cited by 22 publications

(10 citation statements)

References 57 publications

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“…In general, the main compound present in the essential oil is responsible for the biological activity. However, the combination of these substances may increase the activity of the essential oil since the compounds may interact with each other resulting in a synergistic effect (Feitosa-Alcantara et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

et al. 2019

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Canine Monocytic Ehrlichiosis (CME) is an infectious disease caused by the rickettsia organism Ehrlichia canis which is transmitted mainly the ixodid brown dog tick Rhipicephalus sanguineus . The prevalence of E. canis infection has been increasing in recent years. The World Health Organization has been warned about antibiotics resistance and one of the way to prevent this situation is found new compound with this property. Doxycycline is the treatment of choice for this tick-borne disease. Adverse effects are noted in dogs that are sensitive to this drug. Antibiotic resistance may also occur. The present study aimed to evaluate the anti- Ehrlichia properties of the essential oil of the aerial parts of Ageratum conyzoides L. in infected DH82 cells, as well as its anti- Ehrlichia activity associated with doxycycline using the checkerboard assay. A. conyzoides is a native plant from northeast Brazil with many reports of ethnopharmacological applications. The essential oil of A. conyzoides was extracted from the aerial parts of the plant using the hydrodistillation method. E. canis -infected DH82 cells were cultured in DMEM (Dulbecco’s Modified Eagle Medium), maintained at 37 °C and 5% CO 2 , and standardized at a 70% infection rate for the initiation of treatment protocols. The tests were first carried out with the aim of defining the IC 50 . The combined effect of doxycycline and A. conyzoides essential oil was then determined using the checkerboard dilution technique (checkerboard method) in which the IC 50 was 200 µg/mL. The doxycycline reduction index from the combined effect was 4.90 times resulting in a synergistic effect. To the authors’ knowledge, this is the first alternative treatment (alternative therapy) based on bioactive molecules that have antibacterial activity against E. canis .

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Section: Discussionmentioning

confidence: 99%

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

et al. 2019

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“…Essential oil characterization was performed using methods described previously ( Bittrich et al, 2013 ; Ramos et al, 2013 ; Feitosa-Alcantara et al, 2017 ). Specifically, a GC-MS/FID (QP2010 Ultra, Shimadzu Corporation, Kyoto, Japan) equipped with an autosampler (AOC-20i, Shimadzu) was used to separate compounds with an Rtx ® -5MS Restek fused silica capillary column (5%-diphenyl–95%-dimethyl polysiloxane) of 30 m × 0.25 mm i.d., 0.25 μm film thickness, at a constant helium (99.999% purity) flow rate of 1.2 mL⋅min -1 .…”

Section: Methodsmentioning

confidence: 99%

Volatile Metabolomic Composition of Vitex Species: Chemodiversity Insights and Acaricidal Activity

et al. 2017

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The Vitex genus (Lamiaceae) produces a plethora of metabolites that include ecdysteroids and terpenoids, some of which have demonstrated insect repellent properties. The volatile composition of several members of this genus has not been chemically defined, as many taxa are endemic to remote ecosystems. In this study, leaves were collected from the northeast of Brazil from Vitex capitata, V. megapotamica, V. gardneriana, and V. rufescens plants and examined for their chemical profile via GC-MS/FID of essential oil extracts. The analyses showed a diversity of terpenoids. Of particular note were seven-member ring sesquiterpenes which were present in great abundance; a dendrogram showed clades separating by the production of bicyclogermacrene, aromadendrane and 5,10-cycloaromadendrane sesquiterpenoids for the four species. Comparison of volatile metabolite profiles to 13 other Vitex species showed strong similarities in the production of some monoterpenes, but varied by their production of larger terpenes, especially those with gem-dimethylcyclopropyl subunits on seven-member ring compounds. From this work, we suggest that the sesquiterpene skeleton with seven member rings is a good chemosystematic biomarker candidate for the Vitex genus. Separation using this biomarker was then validated using Inter-Simple Sequence Repeat profiling. Lastly, experiments examining the toxicity of these four oils against the coconut mite Aceria guerreronis showed that only the oil of V. gardneriana had strong acaricidal activity, with an LC50 of 0.85 mg/mL, thus demonstrating its potential for use as a natural pesticide.

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“…Similarly individual treatment of β-caryophyllene is reported to have good contact toxicity against these two ant sp. but with low fumigant toxicity [74]. Fumigant toxicity of limonene, linalool and β-pinene were also reported effective against fire ant Solenopsis invicta (Hymenoptera: Formicidae) [34].…”

Section: Citrus Eo Compounds Against Insect Spmentioning

confidence: 99%

Citrus Essential Oils: A Suite of Insecticidal Compounds

Khanikor¹,

Adhikari²,

Rabha³

2021

Citrus - Research, Development and Biotechnology

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Citrus essential oils (CEOs) and their constituent compounds are being reported to have multifarious activities. In this chapter an attempt is made to discuss the insecticidal activities, as well as CEO profile of different vegetative part of Citrus species and biocidal potentiality of their constituent compounds against diverse insect pests. It is observed that in most of the CEO constituent profile, limonene is the major constituent compound. Other important constituents present in different percentages in different CEOs are β-citronellal, linalool, pinene, β- caryophyllene, β-myrcene, terpinene, citral etc. These plant EO constituents are reported to have insecticidal effects against diverse insect species. Taking the four peel EOs of Citrus limon, Citrus paradisi, Citrus medica, Citrus maxima commonly grown in North Eastern part of India, study on their insecticidal effects against Dolichoderus affinis (Hymenoptera: Formicidae) was made and result is presented showing higher fumigant toxicity of C. medica and C. limon oil against the ant sp. With the increasing awareness for using safe insecticidal products among consumers, the citrus EOs with their attracting terpene compounds having good insecticidal potency bear all attributes to be used as commercial green pesticides in coming days both in indoor and outdoor management of insect pests.

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Essential Oils of Hyptis pectinata Chemotypes: Isolation, Binary Mixtures and Acute Toxicity on Leaf-Cutting Ants

Cited by 22 publications

References 57 publications

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

Volatile Metabolomic Composition of Vitex Species: Chemodiversity Insights and Acaricidal Activity

Citrus Essential Oils: A Suite of Insecticidal Compounds

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