Essential Oils from Bolivia. XI. Verbenaceae :<i>Aloysia gratissima</i>(Gillies &amp; Hook.) Tronc. and Boraginaceae :<i>Cordia chacoensis</i>Chodat

Arze, Javier Bernardo Lopez; Collin, Guy J.; Garneau, François-Xavier; Jean, France-Ida; Gagnon, Hélène

doi:10.1080/0972060x.2013.831553

Cited by 8 publications

(9 citation statements)

References 12 publications

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“…Within the Cordia genus , there is a certain variation in the predominance of certain components of essential oils. Some species mainly contain monoterpene hydrocarbons common to C. cylindrostachia [ 50 ], C. globosa [ 51 ]; some sesquiterpene hydrocarbons, as seen in C. verbenacea [ 6 ], C. leucocephala [ 52 ] and C. millenii [ 53 ]; a mixture of monoterpene hydrocarbons and sesquiterpenes prominent in C. trichotoma [ 54 ] and C. multispicata [ 55 ]; oils containing oxygenated monoterpenes/sesquiterpenes, such as C. myxa [ 56 ] and C. chacoensis [ 57 ], respectively; and oils with a high content of non-terpenes, present in C. sebestena [ 58 ] and C. gilletii [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

et al. 2021

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The species Cordia verbenacea DC (Boraginaceae), known as the whaling herb and camaradinha, is a perennial shrub species native to the Atlantic Forest. Its leaves are used in folk medicine as an anti-inflammatory, analgesic, antiulcerogenic and curative agent, in the form of teas or infusions for internal or topical use. The present study aimed to verify the cytotoxicity of the essential oil and the leishmanicidal and trypanocidal potential of C. verbenacea. The essential oil was characterized by GC-MS. The in vitro biological activity was determined by anti-Leishmania and anti-Trypanosoma assays. The cytotoxixity was determined using mammalian fibroblasts. The C. verbenacea species presented α-pinene (45.71%), β-caryophyllene (18.77%), tricyclo[2,2,1-(2.6)]heptane (12.56%) as their main compounds. The essential oil exhibited strong cytotoxicity at concentrations below 250 μg/mL (LC50 138.1 μg/mL) in mammalian fibroblasts. The potent anti-trypanosome and anti-promastigote activities occurred from the concentration of 62.5 μg/mL and was considered clinically relevant. The results also demonstrate that at low concentrations (<62.5 μg/mL), the essential oil of C. verbenacea managed to be lethal for these activities. This can be considered an indication of the power used in daily human consumption. Therefore, it can be concluded that the essential oil of C. verbenacea contains a compound with remarkable antiparasitic activities and requires further research.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

et al. 2021

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“…Essential oil a-Pinene C. curassavica [211] C. cylindrostachya [136] C. verbenacea [137,138] Leaves Twigs and Leaves Flower, Leaves a-Humulene C. globosa [51] C. verbenacea [106,139] Leaves a-Cadinol C. trichotoma [62] Wood a-Muurolol C. trichotoma [62] Wood 6a-Hydroxygermacra-1(10) 4-diene C. chacoensis [140] b-Caryophyllene C. boissieri [141,142] C. chacoensis [135,143] C. curassavica [41] C. globosa [144] C. leucocephala [135] C. leucomalloides [145] C. multispicata [138] C. verbenacea [106,139] Flower Leaves Flowers, Stem Aerial parts, Leaves b-Pinene C. curassavica [135] Leaves b-Eudesmol C. curassavica [146] Aerial parts b-Phellandrene C. multispicata [144] Leaves, flowers, Stem d-Cadinene C. leucomalloides [135] C. trichotoma [72] C. verbenacea [138] Leaves Wood Leaves Aromadendrene C. chacoensis [142] Alloaromadendrene C. verbenacea [137] Flower, leaves Bicyclogermacrene C. curassavica [135] C. globosa [41,143] C. leucocephala [135] C. leucomalloides [145] C. verbenacea [138] Leaves Aerial parts, Leaves Cadinene C. chacoensis [142] Camphene C. cylindrostachya [136] Twigs and leaves Elemol C. chacoensis [142] Germacrene D C. leucomalloides [135] C. ver...…”

Section: Phenolic Acidsmentioning

confidence: 99%

“…exaltata [92] Bark Rufescenolide B (127) C. americana [97] Bark Rufescenolide C (128) C. americana [97] Bark Rufescenolide D (129) C. americana [97] Bark Yunnaneic acid I (130) C. americana [97] Bark Yunnaneic acid J (131) C. americana [97] Bark [61] Root bark Cordicilin (134) C. latifolia [77] Leaves Latifolicinin A (135) C. latifolia [98] Fruit Latifolicinin B (136) C. latifolia [98] Fruit Latifolicinin C (137) C. latifolia [98] Fruit Latifolicinin D (138) C. latifolia [98] Fruit 2.11. Phenolics 2-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-Me propionamide C. macleodii [128] Leaves and flower Methyl caffeate C. rufescens [123] Stem Methyl rosmarinate (139) C. dichotoma [101] C. rufescens [123] Leaves Stem Magnesium lithospermate (140) C. spinescens [135] Leaves Calcium rosmarinate (141) C. spinescens [135] Leaves Magnesium rosmarinate (142) C. spinescens [135] Leaves…”

Section: Abietane Diterpenesmentioning

confidence: 99%

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genusCordia(Boraginaceae)

Oza

Kulkarni

2017

Journal of Pharmacy and Pharmacology

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Objectives Cordia (family Boraginaceae) is a genus of deciduous flowering trees or shrubs comprising more than 300 species distributed widely in the tropical regions. The aim of this review was to provide exhaustive scientific information on traditional uses, phytochemistry and pharmacological activities of the 36 important species with medicinal value from the genus Cordia, to divulge prospects for further research on its therapeutic potential. Key findings Leaves, fruit, bark and seed of a majority of the species were found to possess abundant ethnomedicinal value, but leaves were found to be used most frequently to treat many ailments such as respiratory disorders, stomach pain, wound, inflammation, myalgia, cough, dysentery and diarrhoea. The phytochemical investigation of 36 species resulted in isolation of 293 chemical constituents from various chemical classes. The crude extracts, fractions, essential oils and pure compounds isolated from various Cordia species were reported to have a varied range of pharmacological activities. Summary Many of the traditional uses of the genus Cordia were supported by the results obtained from pharmacological studies performed using various extracts or pure compounds. More attention should be given to the biological evaluation using pure phytochemicals and to identify the mechanism of actions and exploring this genus for new drug discovery.

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“…The two above-cited studies were carried out in the Santa Maria city, Rio Grande do Sul (Brazil). Arze et al [ 16 ] identified the constituents sabinene, ß -pinene, and ß -caryophyllene in the essential oil of A. gratissima collected in the Cochabamba Province of Mizque (Bolivia). The essential oil of A. gratissima collected in the São Carlos city, São Paulo (Brazil), studied by Trovati et al [ 27 ], presents isopinocamphone (25.4%), limonene (15.1%), and guaiol (12.7%) as its major constituents.…”

Section: Resultsmentioning

confidence: 99%

Biological Properties of Aloysia gratissima (Gillies & Hook.) Tronc. (Verbenaceae)

Souza

Petry

Morgan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Aloysia gratissima is a plant native to America, with applications in folk medicine for a wide range of diseases, such as bronchial infections, lung disorders, nervous system disorders (depression, anxiety), and inflammatory processes, among others. However, investigations about this species and its biological actions are still scarce. This literature review was carried out using articles published in the past 30 years on the PubMed, SciELO, and Web of Science platforms, with the focus on the method of extraction, chemical composition, and clinical and preclinical studies on the pharmacological properties of A. gratissima. We noticed that the main constituents of A. gratissima are guaiol, pinocamphone, ß-pinene, and 1,8-cineole. Additionally, preclinical studies reveal that A. gratissima extracts present antidepressant, anti-inflammatory, antinociceptive, antibacterial, antifungal, and virucidal effects. The results also demonstrate that there is a greater interest on the part of researchers from 2012 onwards in studying A. gratissima extracts with potential for possible new drugs.

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Essential Oils from Bolivia. XI. Verbenaceae :Aloysia gratissima(Gillies & Hook.) Tronc. and Boraginaceae :Cordia chacoensisChodat

Cited by 8 publications

References 12 publications

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genusCordia(Boraginaceae)

Biological Properties of Aloysia gratissima (Gillies & Hook.) Tronc. (Verbenaceae)

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