Essential Oils as Potential Antimicrobial Agents

Varijakzhan, Disha; Yang, Shun-Kai; Chong, Chou Min; Akseer, Riaz; Alhosani, Maryam Sultan; Thomas, Warren; Lai, Kok Song; Lim, Swee Hua Erin

doi:10.1007/978-3-030-58259-3_4

Cited by 8 publications

(6 citation statements)

References 105 publications

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“…Majority of the marine natural products can be classified assterols, terpenoids, alkaloids, peptides, polysaccharides, acetogenins, polyketoids, polyacetylenes, shikimates and toxins (Blunt et al, 2016). Terpenoids consist of repeated units of isoprene (C5H8), imparting significant bioactivities (Bakkali et al, 2008;Ebada and Proksch, 2012;Varijakzhan et al, 2021). Many alkaloids isolated from marine sponges have been reported to possess antimalarial activity (Ang et al, 2000).…”

Section: The Potential Of Therapeutics From Marine Biodiversitymentioning

confidence: 99%

The landscape of nature-derived antimalarials-potential of marine natural products in countering the evolving Plasmodium

Prashar

Thakur²,

Chakraborti³

et al. 2022

Front. Drug. Discov.

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Malaria poses several challenges to the global research community on both diagnostic and therapeutic fronts. Most prominent of them are deletion of target genes (pfhrp2/3) used in rapid diagnostic tests (RDTs) and the emergence of resistance against frontline antimalarials by the evolving parasite. Exploration of novel therapeutics for malaria in view of limited vaccine options is a promising resort for malaria control and elimination. The scope of marine-derived chemotherapeutics is exciting, with a significant number of FDA-approved drugs or therapeutic leads under clinical trials for other diseases. This review article discusses the significant antimalarial potential of marine-derived natural products extracted from diverse biota including sponges, bacteria, sea hare and algae etc. Bioassay-guided fractionation of raw extracts from marine organisms for lead identification and further structural characterization of purified compounds compose a sustainable marine-derived drug discovery pipeline; which can be particularly diverted towards the exploration of antimalarials. It is to be noted that the Indian peninsula is largely unexplored, particularly for antimalarials screening; which has a huge marine biodiversity owing to the three distinct water bodies- Bay of Bengal, Indian Ocean and Arabian sea. This review also envisions a collaborative initiative to explore the potential of marine natural products in an economically feasible manner.

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Section: The Potential Of Therapeutics From Marine Biodiversitymentioning

confidence: 99%

The landscape of nature-derived antimalarials-potential of marine natural products in countering the evolving Plasmodium

Prashar

Thakur²,

Chakraborti³

et al. 2022

Front. Drug. Discov.

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“…The nagelamide Q molecule contains a pyrrolidine ring, but the bromopyrrole alkaloid nagelamide R would be the first to have an oxazoline ring (Araki et al, 2009). Both substances had MIC values of 13.0 g/mL against B. subtilis, and at doses greater than 25 g/mL, they were both effective against E. coli, M. luteus, and S. aureus (Varijakzhan et al, 2021b). For instance, the synthetic analogs of the bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine may have both antibacterial and biofilm-preventing effects.…”

Section: Antibacterial Activity Of Various Compounds Isolated From Ma...mentioning

confidence: 99%

Marine sponge's biological activities: Their Biotechnological Uses

Al-Adaileh

Al-Madadheh

Almashaleh

2022

J. basic appl. Res. Biomed.

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The most of the time, marine sponges are an invertebrate species found in the tropics, subtropics, and temperate zones of the oceans and seas. They are acknowledged as being among the most important sources of bioactive chemicals, which are found in marine habitats and can then be recovered from those settings. These bioactive chemicals are found in marine environments and can then be extracted from those environments. It is common knowledge that the chemicals that are extracted from these sponges demonstrate a wide range of bioactivities, such as antibacterial activity, anticancer activity, and general cytotoxicity. These bioactivities can be found in the isolated chemicals. In this article, we discuss the bioactive chemicals that have been found in marine sponges and their potential applications. These compounds have the potential to serve as antibacterial, antiviral, and antimalarial agents against human infections as well as fish pathogens in the aquaculture industry. In addition, these compounds may also operate as antifungal agents. Sponge organisms found in the ocean have also been shown to have these chemical compounds. This article discusses the importance of marine sponges to the fields of chemistry, microbiology, cell biology, and molecular biology from a biotechnological standpoint. Researchers of marine natural products have discovered new potential medications as a result of their efforts to exploit the remarkable chemical variety that can be found in sponges.

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“…Herbal compounds have been considered promising natural and effective growth promoters, antibacterial agents, and immunoprophylactic agents for finfish ( 100 – 103 ) and improve appetite and alleviate stress-mediated effects in fish ( 104 ). In the last few decades, investigation of the effectiveness of the application of herbal medicines as immunomodulators in aquaculture has been conducted to reduce the use of chemicals and antibiotics during production ( 105 , 106 ). In fact, herbal medicine or plant extracts are rich in various biologically active substances with beneficial health properties, such as saponins, alkaloids, waxes, carotenoids, vitamin, terpenoids, tannic acid, organic acids, volatile oils, polysaccharides, glycosides, flavonoids, and others, are considered to benefit aquatic animals with improved growth and immune performance ( 107 – 110 ).…”

Section: Orally Administered Immunoprophylactics and The Implication In The Gut Immune Systemmentioning

confidence: 99%

Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture

et al. 2021

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The gastrointestinal immune system plays an important role in immune homeostasis regulation. It regulates the symbiotic host-microbiome interactions by training and developing the host’s innate and adaptive immunity. This interaction plays a vital role in host defence mechanisms and at the same time, balancing the endogenous perturbations of the host immune homeostasis. The fish gastrointestinal immune system is armed with intricate diffused gut-associated lymphoid tissues (GALTs) that establish tolerance toward the enormous commensal gut microbiome while preserving immune responses against the intrusion of enteric pathogens. A comprehensive understanding of the intestinal immune system is a prerequisite for developing an oral vaccine and immunostimulants in aquaculture, particularly in cultured fish species. In this review, we outline the remarkable features of gut immunity and the essential components of gut-associated lymphoid tissue. The mechanistic principles underlying the antigen absorption and uptake through the intestinal epithelial, and the subsequent immune activation through a series of molecular events are reviewed. The emphasis is on the significance of gut immunity in oral administration of immunoprophylactics, and the different potential adjuvants that circumvent intestinal immune tolerance. Comprehension of the intestinal immune system is pivotal for developing effective fish vaccines that can be delivered orally, which is less labour-intensive and could improve fish health and facilitate disease management in the aquaculture industry.

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Essential Oils as Potential Antimicrobial Agents

Cited by 8 publications

References 105 publications

The landscape of nature-derived antimalarials-potential of marine natural products in countering the evolving Plasmodium

The landscape of nature-derived antimalarials-potential of marine natural products in countering the evolving Plasmodium

Marine sponge's biological activities: Their Biotechnological Uses

Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture

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