Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement

Sharma, Mansi; Grewal, Kamaljit; Jandrotia, Rupali; Batish, Daizy R.; Singh, Harminder Pal; Kohli, R. K.

doi:10.1016/j.biopha.2021.112514

Cited by 93 publications

(66 citation statements)

References 212 publications

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“…These findings confirm the results obtained in previous studies using other essential oils [ 16 , 28 , 38 , 39 ]. For instance, the use of essential oils in aromatherapy, thanks to their validated analgesic, anti-inflammatory, calming, and relaxing effects, has been proven to alleviate physical and emotional disorders in cancer patients [ 40 ]. This makes it reasonable to infer that aromatherapy represents a helpful alternative method for anxiety and pain control [ 41 , 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Neroli Essential Oil in Relieving Anxiety and Perceived Pain in Women during Labor: A Randomized Controlled Trial

et al. 2022

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Childbirth is a stressful and physically painful event in a woman’s life and aromatherapy is one of the most used non-pharmacological methods that is effective in reducing anxiety and perceived pain. This randomized controlled study aimed at determining the effect of neroli oil aromatherapy on anxiety and pain intensity perception in 88 women during labor, randomly assigned to either an intervention group (n = 44) or control group (n = 44). Anxiety and perceived pain were assessed through the visual analogue scale during the latent, early, and late active phases of labor. Data analyses included the t-test, Chi-square test, and repeated measures ANOVA. Perceived pain and anxiety in the group receiving aromatherapy were significantly lower than in the control group at all stages of labor (p < 0.05). Specifically, as the labor progressed, pain and anxiety increased in all participants, but the increase was milder in the experimental group than in the control group. The multiparas showed higher average anxiety scores, but not perceived pain, than the primiparas in all phases of labor (p < 0.05). Ultimately, neroli oil aromatherapy during labor can be used as an alternative tool to relieve anxiety and perceived pain in women during all stages of labor.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Neroli Essential Oil in Relieving Anxiety and Perceived Pain in Women during Labor: A Randomized Controlled Trial

et al. 2022

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“…One of the most important biological aspects of essential oils for dealing with oxidative stress is their antioxidant activity. In eukaryotes, reactive oxygen species (ROS) such as hydroxyl radicals, superoxide anions, and hydrogen peroxide cause mitochondrial DNA damage, which slows the electron transport chain, resulting in ROS accumulation [42]. The antioxidant activity of the essential oil was assessed using the 2,2′diphenyl-1-picrylhydrazyl (DPPH) test in this study.…”

Section: Discussionmentioning

confidence: 99%

“…This is accompanied by an increase in the affected cell's membrane fluidity, a decrease in adenosine triphosphate (ATP) production, a change in pH gradient, and the loss of mitochondrial potential, all of which are key precursors to cell death. [42] MTT assay was carried out to determine anticancer activity of Cymbopogon martini Essential oil on Hela cells. Metabolic activity can be assessed by determining the activity of a mitochondrial enzyme succinate dehydrogenase using MTT assay.…”

Section: Discussionmentioning

confidence: 99%

GC-MS Analysis, Thermal Characterization and Biomedical Applications of Essential Oil from Cymbopogon martinii: In vitro Approach

Jha¹,

Gharat

Kaur³

et al. 2022

AIR

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Background: Plant derived metabolites have served as the foundation of sophisticated systems in traditional medicine that have existed for hundreds of years and continue to supply mankind with novel treatments. Owing to its antibacterial characteristics, Gingergrass (Cymbopogon martinii) has been utilized in aromatherapy as a skin tonic. It's also been employed in Ayurvedic medicine to treat skin conditions and nerve discomfort. It helps with neuralgia, epilepsy, and anorexia, among other central nervous system disorders. Geraniol, the main constituent of Cymbopogon martinii essential oil, has numerous biological properties, including antibacterial, antioxidant, and anti-inflammatory activities, and may constitute a new class of therapeutic medicines against pancreatic and colon malignancies. In this study, an attempt was made to explore the physiochemical and bioactive properties of Cymbopogon martinii Essential oil to understand the chemical composition and thermal stability of the oil along with its efficacy against biological agents. The hydro-distillation method was used to extract the Gingergrass (Cymbopogon martinii) Essential oil and its chemical composition as well as Thermal characteristics was determined. The essential oil's potential to scavenge free radicals was evaluated, as well as its anti-inflammatory effect was determined. The essential oil's antibacterial potential was tested against a variety of drug-resistant microorganisms, while its antimalarial efficacy was investigated against Plasmodium falciparum. In addition, the EO was tested against Hela and CHO cell lines for anticancer and cytotoxic activities, respectively. Results: The GC-MS Analysis of the essential oil characterized 10 major compounds which included different classes of alcohols, esters, ketones, monoterpenes and sesquiterpenes. Thermogravimetric and differential calorimetric analysis revealed that the oil showed a stable thermograph when exposed to constant increasing temperatures. The essential oil exhibited promising antimicrobial and antimalarial activity against the drug-resistant pathogens. Further, moderate free radical scavenging activity was observed during DPPH Assay. The essential oil also showed reliable anti-inflammatory, anticancer and cytotoxic activity. Conclusion: According to the research, Cymbopogon martinii essential oil has a number of medicinal benefits and can be used as a therapeutic agent to address a range of health issues.

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“…For example, Ali et al [101] used nanosuspensions and One of the strategic research directions of nanomedicine is to improve targeted and/or controlled drug delivery [49,56,[94][95][96][97][98][99][100][101][102]. In addition, there is a need to improve EO stability and bioavailability along with cancer targeting through delivery system [103].…”

Section: Nanodelivery Systems For Eosmentioning

confidence: 99%

Nanomedicine as an Emerging Technology to Foster Application of Essential Oils to Fight Cancer

AbouAitah

Łojkowski

2022

Pharmaceuticals

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Natural prodrugs extracted from plants are increasingly used in many sectors, including the pharmaceutical, cosmetic, and food industries. Among these prodrugs, essential oils (EOs) are of particular importance. These biologically active volatile oily liquids are produced by medicinal and aromatic plants and characterized by a distinctive odor. EOs possess high anticancer, antibacterial, antiviral, and antioxidant potential but often are associated with low stability; high volatility; and a high risk of deterioration with exposure to heat, humidity, light, or oxygen. Furthermore, their bioavailability is limited because they are not soluble in water, and enhancements are needed to increase their potential to target specific cells or tissues, as well as for controlled release. Nanomedicine, the application of nanotechnology in medicine, may offer efficient solutions to these problems. The technology is based on creating nanostructures in which the natural prodrug is connected to or encapsulated in nanoparticles or submicron-sized capsules that ensure their solubility in water and their targeting properties, as well as controlled delivery. The potential of EOs as anticancer prodrugs is considerable but not fully exploited. This review focusses on the recent progress towards the practical application of EOs in cancer therapy based on nanotechnology applications.

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Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement

Cited by 93 publications

References 212 publications

The Effectiveness of Neroli Essential Oil in Relieving Anxiety and Perceived Pain in Women during Labor: A Randomized Controlled Trial

The Effectiveness of Neroli Essential Oil in Relieving Anxiety and Perceived Pain in Women during Labor: A Randomized Controlled Trial

GC-MS Analysis, Thermal Characterization and Biomedical Applications of Essential Oil from Cymbopogon martinii: In vitro Approach

Nanomedicine as an Emerging Technology to Foster Application of Essential Oils to Fight Cancer

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