Essential Oils as a Source of Ecofriendly Insecticides for Drosophila suzukii (Diptera: Drosophilidae) and Their Potential Non-Target Effects

Souza, Michele Trombin de; Souza, Mireli Trombin de; Morais, Maíra Chagas; Oliveira, Daiana da Costa; Melo, Douglas José de; Figueiredo, Leonardo Souza Reis; Zarbin, Paulo H. G.; Zawadneak, María Aparecida Cassilha; Bernardi, Daniel

doi:10.3390/molecules27196215

Cited by 10 publications

(3 citation statements)

References 56 publications

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“…Considering that EOs may be used in both conventional and organic agriculture with little or no environmental impact, their use as bioinsecticides is of great interest [ 45 ]. Although EOs have a complex chemical composition and can act on multiple sites, most of the paralysis and death of insects caused by these mixtures is explained by damage to the central nervous system [ 46 ]. From the literature data, it has been observed that P. graveolens EO, commonly referred to as geranium EO, has insecticidal and insect-repelling qualities.…”

Section: Discussionmentioning

confidence: 99%

An In-Depth Study on the Chemical Composition and Biological Effects of Pelargonium graveolens Essential Oil

Kačániová,

Vukic,

Vukovic

et al. 2023

Foods

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The essential oil of Pelargonium graveolens (PGEO) is identified in the literature as a rich source of bioactive compounds with a high level of biological activity. This study aimed to examine the chemical profile of PGEO as well as its antioxidant, antibacterial, antibiofilm, and insecticidal properties. Its chemical composition was analyzed using gas chromatography–mass spectrometry (GC-MS), achieving comprehensive identification of 99.2% of volatile compounds. The predominant identified compounds were β-citronellol (29.7%) and geraniol (14.6%). PGEO’s antioxidant potential was determined by means of DPPH radical and ABTS radical cation neutralization. The results indicate a higher capacity of PGEO to neutralize the ABTS radical cation, with an IC50 value of 0.26 ± 0.02 mg/mL. Two techniques were used to assess antimicrobial activity: minimum inhibitory concentration (MIC) and disk diffusion. Antimicrobial evaluation using the disk diffusion method revealed that Salmonella enterica (14.33 ± 0.58 mm), which forms biofilms, and Priestia megaterium (14.67 ± 0.58 mm) were most susceptible to exposure to PGEO. The MIC assay demonstrated the highest performance of this EO against biofilm-forming S. enterica (MIC 50 0.57 ± 0.006; MIC 90 0.169 ± 0.08 mg/mL). In contrast to contact application, the assessment of the in situ vapor phase antibacterial activity of PGEO revealed significantly more potent effects. An analysis of antibiofilm activity using MALDI-TOF MS demonstrated PGEO’s capacity to disrupt the biofilm homeostasis of S. enterica growing on plastic and stainless steel. Additionally, insecticidal evaluations indicated that treatment with PGEO at doses of 100% and 50% resulted in the complete mortality of all Harmonia axyridis individuals.

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Section: Discussionmentioning

confidence: 99%

An In-Depth Study on the Chemical Composition and Biological Effects of Pelargonium graveolens Essential Oil

Kačániová,

Vukic,

Vukovic

et al. 2023

Foods

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“…The reduced number of effective control practices for D. suzukii has been a serious problem for cherry and berry production in the Neotropical region [ 1 , 2 , 50 , 51 , 52 , 53 ]. The reliance on a reduced number of molecules can either be worsened by the fact that some of these molecules can also have detrimental effects on non-target organisms [ 54 , 55 ]. For instance, T. anastrephae has been shown to be susceptible to the conventional insecticides used in the management of D. suzukii [ 7 , 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids

Mantilla‐Afanador

Araújo

Teixeira

et al. 2023

Insects

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Drosophila suzukii, an invasive insect pest, poses a significant threat to various fruit crops. The use of broad-spectrum insecticides to control this pest can reduce the effectiveness of biological control agents, such as the parasitoid Trichopria anastrephae. Here, we evaluated the toxicity of newly synthesized lactone derivatives on D. suzukii and their selectivity towards T. anastrephae. We used in silico approaches to identify potential targets from the most promising molecules in the D. suzukii nervous system and to understand potential differences in susceptibilities between D. suzukii and its parasitoid. Of the nine molecules tested, (rac)-8 and compound 4 demonstrated efficacy against the fly. Exposure to the estimated LC90 of (rac)-8 and compound 4 resulted in a mortality rate of less than 20% for T. anastrephae without impairing the parasitoid’s functional parasitism. The in silico predictions suggest that (rac)-8 and compound 4 target gamma amino butyric acid (GABA) receptors and transient receptor potential (TRP) channels of D. suzukii. However, only the reduced interaction with TRP channels in T. anastrephae demonstrated a potential reason for the selectivity of these compounds on the parasitoid. Our findings suggest the potential for integrating (rac)-8 and compound 4 into D. suzukii management practices.

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“…There have been some experiments using essential oils and fruit flies as a model organism, specifically the species D . melanogaster and Drosophila suzukii [ 24 – 26 ]. However, while these studies have analyzed the larvicidal and insecticidal effects of essential oils, our purpose on this study is to evaluate their toxicity and therapeutic potential in this model, aiming to propose this animal model as a replacement for chordate ones.…”

Section: Introductionmentioning

confidence: 99%

Drosophila melanogaster as a model for studies related to the toxicity of lavender, ginger and copaiba essential oils

Bernardes,

Malta,

Rodrigues

et al. 2023

PLoS ONE

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This study addresses the current trend of essential oils in alternative medicine using the non-chordate model Drosophila melanogaster. Following the three R’s principles, it proposes non-chordate models to fill knowledge gaps on essential oil toxicity. Copaiba, lavender, and ginger essential oils are evaluated for effects on D. melanogaster lifespan, climbing ability, and brain structure, while their anti-inflammatory properties are also analyzed. Results show dose-related differences: higher concentrations (0.25% v/v) cause brain deterioration and impaired climbing, while lower concentrations (0.0625% v/v for copaiba and ginger; 0.125% for lavender) have no effect on climbing or brain structure. Lavender oil significantly extends lifespan and maintains anti-inflammatory activity when ingested, underscoring its therapeutic potential. These findings highlight the importance of D. melanogaster as a model for studying essential oil properties, potentially replacing chordate models. In addition, this research advances alternative remedies for currently incurable diseases, with lavender oil emerging as a promising candidate for drug discovery.

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Essential Oils as a Source of Ecofriendly Insecticides for Drosophila suzukii (Diptera: Drosophilidae) and Their Potential Non-Target Effects

Cited by 10 publications

References 56 publications

An In-Depth Study on the Chemical Composition and Biological Effects of Pelargonium graveolens Essential Oil

An In-Depth Study on the Chemical Composition and Biological Effects of Pelargonium graveolens Essential Oil

Novel Lactone-Based Insecticides and Drosophila suzukii Management: Synthesis, Potential Action Mechanisms and Selectivity for Non-Target Parasitoids

Drosophila melanogaster as a model for studies related to the toxicity of lavender, ginger and copaiba essential oils

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