Essential oils and metal ions as alternative antimicrobial agents: a focus on tea tree oil and silver

Low, Wan Li; Kenward, Ken; Britland, Stephen; Amin, Mohd Cairul Iqbal Mohd; Martin, Claire

doi:10.1111/iwj.12611

Cited by 31 publications

(23 citation statements)

References 142 publications

(225 reference statements)

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“…BCP is a plant-derived natural product, which could act as an alternative antibacterial agent or adjuvant in combating antibiotic resistance. A new strategy such as combinatorial treatment using natural compound and antibiotic, disruptive metals or nanotechnologies has recently gained much attention in tackling antimicrobial resistance, especially in multi-resistant strains of bacteria (Kwiatkowski et al 2017;Low et al 2017;Moo et al 2019). The results of this work could be extrapolated to a combinatorial treatment and also at the molecular level using high-throughput screening study before the application of BCP for treatment regimes.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity and Mode of Action of β-caryophyllene on Bacillus cereus

Moo

Yang

Osman

et al. 2020

Polish Journal of Microbiology

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A b s t r a c t Natural products such as essential oils (EOs) are secondary metabolites that can be obtained from either plant or animal sources or produced by microorganisms. Much attention has been given to exploring the use of secondary metabolites as natural antibacterial agents. This study investigates the antibacterial activity and mechanism of β-caryophyllene, a compound that can be found in various EOs, against Bacillus cereus. The minimum inhibitory concentration of β-caryophyllene against B. cereus was 2.5% (v/v), whereas killing kinetics of β-caryophyllene at minimum inhibitory concentration recorded complete bactericidal activity within 2 hours. Zeta-potential measurement in the cells treated with half the minimum inhibitory concentration of β-caryophyllene at 1.25% (v/v) showed an increase in the membrane permeability surface charge to -3.98 mV, compared to untreated cells (-5.46 mV). Intracellular contents leakage of UV-absorbing materials was detected in the cells treated with β-caryophyllene. Additionally, β-caryophyllene does not interfere with the efflux activity of B. cereus via the ethidium bromide influx/efflux activity. The results revealed that β-caryophyllene was able to alter membrane permeability and integrity of B. cereus, leading to membrane damage and intracellular content leakage, which eventually caused cell death. K e y w o r d s: antibacterial, β-caryophyllene, intracellular leakage, membrane damage, zeta potential

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity and Mode of Action of β-caryophyllene on Bacillus cereus

Moo

Yang

Osman

et al. 2020

Polish Journal of Microbiology

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“…From a macroscopic perspective, wound healing depends on multiple parameters, such as wound size, depth, location, patient age, and the presence of local or systemic disease [10]. Other factors, such as nutritional and immunological status, stress, smoking, diabetes, obesity, and hypertension, can also have an impact on wound healing [11,12], together with a generally increased longevity of the elderly population, which has increased the prevalence of non-healing ulcers [12]. In aged skin, the microcirculation, which is very important in wound healing, shows impaired vasoregulation, changed inflammatory responses, and fewer progenitor cells.…”

Section: The Wound Healing Processmentioning

confidence: 99%

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

2019

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Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in the European Union and European Economic Area (EEA) can be estimated as the cumulative burden of tuberculosis, influenza, and human immunodeficiency virus (HIV). In wound management, the control of infections represents a crucial issue and a multi-billion dollar industry worldwide. For diabetic wounds ulcers, in particular, infections are related to the majority of amputations in diabetic patients, which today represent an increasing number of the elderly. The greatest barrier to healing is represented by the biofilm, an organized consortium of bacteria encapsulated in a self-produced extracellular polymeric substance with high resistance to conventional antimicrobial therapies. There is an urgent need for novel anti-biofilm strategies and novel antimicrobial agents and, in this scenario, silver nanotechnology has received tremendous attention in recent years in therapeutically enhanced healthcare. Due to its intrinsic therapeutic properties and the broad-spectrum antimicrobial efficacy, silver nanoparticles have opened new horizons towards novel approaches in the control of infections in wound healing. This review aims at providing the reader with an overview of the most recent progress in silver nanotechnology, with a special focus on the role of silver in the wound healing process.

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“…In this respect, dressings can be functionalized with many classes of antibiotics (such as quinolones [ 10 ], tetracyclines [ 11 ], aminoglycosides [ 12 ], cephalosporins [ 13 ], etc.) or other substances that exhibit antibacterial properties (e.g., essential oils) [ 14 , 15 ]. Antibiotic-embedded wound dressings are valuable in the management of local infections where high concentrations of antibiotics are needed locally [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment Strategies for Infected Wounds

2018

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The treatment of skin wounds is a key research domain owing to the important functional and aesthetic role of this tissue. When the skin is impaired, bacteria can soon infiltrate into underlying tissues which can lead to life-threatening infections. Consequently, effective treatments are necessary to deal with such pathological conditions. Recently, wound dressings loaded with antimicrobial agents have emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process. In this paper, we present an overview of the most prominent antibiotic-embedded wound dressings, as well as the limitations of their use. A promising, but still an underrated group of potential antibacterial agents that can be integrated into wound dressings are natural products, especially essential oils. Some of the most commonly used essential oils against multidrug-resistant microorganisms, such as tea tree, St. John’s Wort, lavender and oregano, together with their incorporation into wound dressings are presented. In addition, another natural product that exhibits encouraging antibacterial activity is honey. We highlight recent results of several studies carried out by researchers from different regions of the world on wound dressings impregnated with honey, with a special emphasis on Manuka honey. Finally, we highlight recent advances in using nanoparticles as platforms to increase the effect of pharmaceutical formulations aimed at wound healing. Silver, gold, and zinc nanoparticles alone or functionalized with diverse antimicrobial compounds have been integrated into wound dressings and demonstrated therapeutic effects on wounds.

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Essential oils and metal ions as alternative antimicrobial agents: a focus on tea tree oil and silver

Cited by 31 publications

References 142 publications

Antibacterial Activity and Mode of Action of β-caryophyllene on Bacillus cereus

Antibacterial Activity and Mode of Action of β-caryophyllene on Bacillus cereus

Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

Treatment Strategies for Infected Wounds

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