ESSENTIAL OIL OF THYMUS PECTINATUS FISCH&MEY.VAR.PECTINATUS: CHEMICAL FORMATION, ANTIMICROBIAL, ANTIOXIDANT, ANTISPASMODIC AND ANGIOGENIC ACTIVITIES

Abstract

Background: Thymus species are well-known as medicinal plants. It was aimed to investigate the chemical composition of Thymus pectinatus (TP) and its antioxidant, antimicrobial, antispasmodic, and angiogenic activities. Materials and Methods: After essential oil of TP (EO-TP) was obtained with clevenger distillation system, it was analyzed for chemical composition with GC-MS. To study antispasmodic activity, eight male Wistar albino rats each weighing approximately 250-300 g were used. Results: The results of the analysis revealed 19 components, which equals to 92.93 of the essential oil. The following are the main components; thymol (48.77%), m-cymene (9.15%), isoborneol (5.19%), trans-caryophyllene (4.43%), carvacrol (3.91%) and -terpinene (3.54%). It has been found that microorganisms subjected to whole all of microbiological tests are highly resistant to EO-TP. 2,2- diphenyl-l-picrylhydrazyl, hydroxyl radical, along with superoxide radical scavenging, and lipid peroxidation says were utilized to show the antioxidant activities of the EO-TP. In measuring its effect, 0.1 mg/mL and 0.5 mg/mL dosage of the EO-TP was applied to the rat ileum as a result of which the magnitude and the frequency of the contractions were observed to be significantly. Conclusion: It was also understood that EO-TP had angiogenic effect upon the vein system of the embryos of chicks. There is a need for further studies to clarify the mechanisms of antimicrobial, antioxidant and angiogenic effects and to determine the constituents of EO-TP responsible from these effects, especially the angiogenic.

Liquid chromatography–tandem mass spectrometry profile and antioxidant, antimicrobial, antiproliferative, and enzyme activities of Thymus pectinatus and Thymus convolutus: in vitro and in silico approach

“…Thymus species are known for their antibacterial activities, which are attributed to secondary plant metabolites, polyphenols, and essential oils. 63,64 Contrary to the results, it was previously reported in the literature that the methanol extract of TP showed no (or very little) antimicrobial activity. 33 The main compound of the TP and TC extracts is rosmarinic acid (144 mg/g extract and 163 mg/g extract respectively) followed by quinic acid (34 mg/g extract and 65 mg/g extract respectively).…”

“…They were used as spices and for seasoning of meatballs by local communities. Previous studies have reported the chemical composition and antioxidant, anticancer, antifungal, antispasmodic, and angiogenic activities of the essential oil of TP and TC 30‐34 . However, there are limited studies in the literature on the extracts of these plants.…”

“…Previous studies have reported the chemical composition and antioxidant, anticancer, antifungal, antispasmodic, and angiogenic activities of the essential oil of TP and TC. [30][31][32][33][34] However, there are limited studies in the literature on the extracts of these plants. In these studies, the antimicrobial and antioxidant activities of the methanol extract of TP 33 and the phytochemical composition, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibitory activities of the ethanol extract of TC were reported.…”

Scavenging Effect, Chemical Composition and Antispasmodic Activity of the Essential Oil of Origanum Onites L.

“…These synthetic substances may adversely affect health or cause certain diseases (Chan,1987;Barlow, 1990). In recent years for this reason, there is a growing interest in studies of natural additives as potential antioxidants as a natural additive for some plant extracts and essential oils is intended to use (Reynolds, 1996;Tepe et al, 2004;Akkuş-Çetinus et al, 2007;Tepe et al, 2016;Göze Saygın et al, 2018).…”

“…The essential oils of the plants which are widely use as alternative remedies for the treatment of many diseases and natural therapies and pharmaceutical alternative medicine have been gain great interest (Tepe et al, 2004;Akkuş-Çetinus et al 2007;Tepe et al, 2016;Göze Saygın et al, 2018).…”