Essential Oil of Gallesia Integrifolia is Active Against Mycobacteria

Abstract

Background: There is critical need for new therapeutic options for treatment of diseases caused by mycobacteria. Materials & methods: Gallesia integrifolia essential oils (EOs) and crude extracts (CEs) were tested for their anti- Mycobacterium tuberculosis and anti-nontuberculous mycobacteria activity. Results: Minimum inhibitory concentration (MIC) of EOs ranged from 15.63 to 62.5 μg/ml against M. tuberculosis and 62.5 to >250 μg/ml against nontuberculous mycobacteria. CEs showed low activity. All EO tested demonstrated synergism with antituberculosis drugs. The cytotoxicity of EOs and CEs, in different cell lines, showed selectivity index from 2.2 to 9.8 and >0.056 to 2.0, respectively. Conclusion: G. integrifolia EOs are a candidate for the development of new therapeutic options in the treatment of tuberculosis and other mycobacterial diseases.

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

“…Commonly referred to as garlic-wood, árbol de ajo, or pau d’alho, G. integrifolia emits a distinct garlic-like odor attributed to its essential oils, which possess a high concentration of sulfur compounds [ 8 ]. In traditional medicine, the leaves and bark of this plant are utilized for various purposes, including combating influenza, cough, pneumonia, prostate tumors, and rheumatism [ 9 ].…”

“…Studies conducted with essential oils and extracts from this species indicate anti-inflammatory, antiproliferative and antitumor [ 10 ], antifungal [ 8 , 11 ], acaricidal and larvicidal potential against Rhipicephalus microplus [ 12 , 13 ], larvicidal against Aedes aegypt [ 14 ], antiviral [ 15 ], antimycobacterial [ 9 ], and antiulcer [ 16 ] properties.…”