Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 × Tg-AD transgenic mice

Xu, Zhiwei; Zhou, Xin; Xiao, H.; Wang, Sichen; Wei, Jianhong; Huang, Junhao; Ji, Liting; Yang, Yuan; Efferth, Thomas; Hong, Chunlan; Li, Changyu

doi:10.1016/j.phymed.2023.154695

Cited by 15 publications

(14 citation statements)

References 31 publications

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“…Therefore, reactive microglia are an important target for treating neuroinflammation and NDs [ 30 ]. LPS, a glycolipid composed of lipids and polysaccharides, is a constituent of the outer wall of gram-negative bacterial cell walls [ 31 , 32 ]. LPS-induced microglial activation results in a series of inflammatory responses, such as the production of multiple proinflammatory mediators (ROS, RNS, PGE2, NO, iNOS, and COX-2) and cytokines (TNF-α, IL-6, and IL-1β), that further deteriorate neurons [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition

Cao,

Li,

Zhang

et al. 2024

Nat. Prod. Bioprospect.

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Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, in-house natural product database screening revealed that libertellenone C (LC) obtained from the fermentation products of Arthrinium arundinis separated from the gut of a centipede collected in our Tongji campus, showed a remarkable neuroprotective effect. Further investigation was conducted to clarify the specific mechanism. LC dose-dependently reversed glutamate-induced decreased viability, accumulated reactive oxygen species, mitochondrial membrane potential loss, and apoptosis in SH-SY5Y cells. Network pharmacology analysis predicted that the targets of LC were most likely directly related to oxidative stress and the regulation of inflammatory factor-associated signaling pathways. Further study demonstrated that LC attenuated nitrite, TNF-α, and IL-1β production and decreased inducible nitric oxide synthase and cyclooxygenase expression in lipopolysaccharide-induced BV-2 cells. LC could directly inhibit NLRP3 inflammasome activation by decreasing the expression levels of NLRP3, ASC, cleaved Caspase-1, and NF-κB p65. Our results provide a new understanding of how LC inhibits the NLRP3 inflammasome in microglia, providing neuroprotection. These findings might guide the development of effective LC-based therapeutic strategies for NDs.

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Section: Discussionmentioning

confidence: 99%

Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition

Cao,

Li,

Zhang

et al. 2024

Nat. Prod. Bioprospect.

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“…EO prevented neuronal damage by reducing Aβ and Tau phosphorylation and associated apoptosis driven by elevated Bax and reduced Bcl-2. Furthermore, the EO decreased both the content and expression of inflammatory mediators including IL-1β, TNF-α, IL-6, and IL-18 [69]. Finally, the authors concluded that the neuroprotective action of the EO arose from the inhibition of the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) and caspase-1 through inhibition of the NF-κB signalling pathway [69].…”

Section: Eos Associated With Plants Used In Chinese Traditional Medicinementioning

confidence: 99%

“…Investigations on the effects of A. tatarinowii EO on neuroinflammation are relatively scarce. Traditional usage of this plant laid the foundation for an in vivo study of the EO on cognitive impairment in the AppSwe/PSEN1M146V/MAPTP301L triple transgenic (3 × Tg-AD) mouse model of AD [69]. The EO applied over eight weeks in doses of 50 and 100 mg/kg improved the animals' cognitive performance in the Morris water maze and step-down avoidance tests.…”

Section: Eos Associated With Plants Used In Chinese Traditional Medicinementioning

confidence: 99%

Essential Oil Constituents as Anti-Inflammatory and Neuroprotective Agents: An Insight through Microglia Modulation

Stojanović,

Ranđelović,

Simonović

et al. 2024

IJMS

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Microglia are key players in the brain’s innate immune response, contributing to homeostatic and reparative functions but also to inflammatory and underlying mechanisms of neurodegeneration. Targeting microglia and modulating their function may have therapeutic potential for mitigating neuroinflammation and neurodegeneration. The anti-inflammatory properties of essential oils suggest that some of their components may be useful in regulating microglial function and microglial-associated neuroinflammation. This study, starting from the ethnopharmacological premises of the therapeutic benefits of aromatic plants, assessed the evidence for the essential oil modulation of microglia, investigating their potential pharmacological mechanisms. Current knowledge of the phytoconstituents, safety of essential oil components, and anti-inflammatory and potential neuroprotective effects were reviewed. This review encompasses essential oils of Thymus spp., Artemisia spp., Ziziphora clinopodioides, Valeriana jatamansi, Acorus spp., and others as well as some of their components including 1,8-cineole, β-caryophyllene, β-patchoulene, carvacrol, β-ionone, eugenol, geraniol, menthol, linalool, thymol, α-asarone, and α-thujone. Essential oils that target PPAR/PI3K-Akt/MAPK signalling pathways could supplement other approaches to modulate microglial-associated inflammation to treat neurodegenerative diseases, particularly in cases where reactive microglia play a part in the pathophysiological mechanisms underlying neurodegeneration.

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“…Limonene was able to alleviate oxidative damage and neuroinflammation in the hippocampus and frontal cortex regions, increasing the levels of antioxidant enzymes and decreasing the release of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), lipid peroxidation, and DNA damage [105,106]. Carvacrol, thymol, eucalyptol, linalool, linalyl acetate, and asarone are all BPMs present in EOs that have been demonstrated to reduce the expression levels of pro-inflammatory mediators in neuroinflammation and have the potential for action in neurodegeneration [107][108][109][110].…”

Section: The Potential Of Bioactive Plant Molecules To Regulate Micro...mentioning

confidence: 99%

Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis

Pribac,

Motataianu,

Andone

et al. 2024

CIMB

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The correlation between neurodegenerative diseases and the gut microbiome is increasingly evident, with amyotrophic lateral sclerosis (ALS) being particularly notable for its severity and lack of therapeutic options. The gut microbiota, implicated in the pathogenesis and development of ALS, plays a crucial role in the disease. Bioactive plant molecules, specifically volatile compounds in essential oils, offer a promising therapeutic avenue due to their anti-inflammatory properties and gut-modulating effects. Our narrative review aimed to identify microbiota-associated bacteria in ALS and analyze the benefits of administering bioactive plant molecules as much-needed therapeutic options in the management of this disease. A comprehensive search of PubMed database articles published before December 2023, encompassing research on cell, human, and animal ALS models, was conducted. After selecting, analyzing, and discussing key articles, bacteria linked to ALS pathogenesis and physiopathology were identified. Notably, positively highlighted bacteria included Akkermansia muciniphila (Verrucomicrobia phylum), Faecalibacterium prausnitzii, and Butyrivibrio spp. (Firmicutes phylum). Conversely, members of the Escherichia coli spp. (Proteobacteria phylum) and Ruminococcus spp. (Firmicutes phylum) stood out negatively in respect to ALS development. These bacteria were associated with molecular changes linked to ALS pathogenesis and evolution. Bioactive plant molecules can be directly associated with improvements in the microbiome, due to their role in reducing inflammation and oxidative stress, emerging as one of the most promising natural agents for enriching present-day ALS treatments.

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Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 × Tg-AD transgenic mice

Cited by 15 publications

References 31 publications

Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition

Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition

Essential Oil Constituents as Anti-Inflammatory and Neuroprotective Agents: An Insight through Microglia Modulation

Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis

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