Essential oil loaded pectin/chitosan nanoparticles preparation and optimization <i>via</i> Box–Behnken design against MCF-7 breast cancer cell lines

Attallah, Olivia A.; Shetta, Amro; Elshishiny, Fatma; Mamdouh, Wael

doi:10.1039/c9ra10204c

Cited by 57 publications

(25 citation statements)

References 25 publications

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“…However, essential oils generally have low stability, high volatility, and a high risk of deterioration by exposure to direct heat, humidity, light, or oxygen [478]. Nanoformulations are a recent strategy being developed for essential oils and their constituents to solve these problems [463,[479][480][481][482].…”

Section: Essential Oilsmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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Section: Essential Oilsmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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“… 81 The outcome was that pec/CS/JO NPs was effective against (MSF-7) breast cancer cells, which was evaluated by using MTT assay, where it was found that normal cells were not affected by the prepared nanoparticle. 81 Guo et al formulated a chitosan-based nanogel to inhibit the proliferation of breast cancer cell lines, where the model drug of 10-hydroxycamptothecin (HCPT) was entrapped into core by facile diffusion to form chitosan/10-hydroxycamptothecin (CS/HCPT). 82 From the prepared formulation the outcome was evaluated by assessing particle size, drug loading content and drug loading efficiency.…”

Section: Resultsmentioning

confidence: 99%

“…Attallah et al prepared pectin/chitosan/jasmine oil nanoparticles (Pec/ CS/JO NPs) by using Box-Behnken design (BBD). 81 The outcome was that pec/CS/JO NPs was effective against (MSF-7) breast cancer cells, which was evaluated by using MTT assay, where it was found that normal cells were not affected by the prepared nanoparticle. 81 Guo et al formulated a chitosan-based nanogel to inhibit the proliferation of breast cancer cell lines, where the model drug of 10hydroxycamptothecin (HCPT) was entrapped into core by facile diffusion to form chitosan/10-hydroxycamptothecin (CS/HCPT).…”

Section: Chitosan-based Pec Nanoparticles Outcomementioning

confidence: 99%

Evaluation of Antitumor Efficacy of Chitosan-Tamarind Gum Polysaccharide Polyelectrolyte Complex Stabilized Nanoparticles of Simvastatin

Malviya

Raj

Fuloria

et al. 2021

IJN

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The present study was intended to fabricate chitosan (Ch)-tamarind gum polysaccharide (TGP) polyelectrolyte complex stabilized cubic nanoparticles of simvastatin and evaluate their potential against human breast cancer cell lines. Materials and Methods: The antisolvent precipitation method was used for formulation of nanoparticles. Factorial design (3 2 ) was utilized as a tool to analyze the effect of Ch and TGP concentration on particle size and entrapment efficiency of nanoparticles. Results: Formulated nanoparticles showed high entrapment efficiency (67.19±0.42-83.36 ±0.23%) and small size (53.3-383.1 nm). The present investigation involved utilization of two biological membranes (egg and tomato) as biological barriers for drug release. The study revealed that drug release from tomato membranes was retarded (as compared to egg membranes) but the release pattern matched that of egg membranes. All formulations followed the Baker-Lansdale model of drug release irrespective of the two different biological barriers. Stability studies were carried out for 45 days and exhibited less variation in particle size as well as a reduction in entrapment efficiency. Simvastatin loaded PEC stabilized nanoparticles exhibited better control on growth of human breast cancer cell lines than simple simvastatin. An unusual anticancer effect of simvastatin nanoparticles is also supported by several other research studies. Conclusion:The present study involves first-time synthesis of Ch-TGP polyelectrolyte complex stabilized nanoparticles of simvastatin against MCF-7 cells. It recommends that, in future, theoretical modeling and IVIVC should be carried out for perfect designing of delivery systems.

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“…Encapsulation of EO has also been applied in fabrication of anticancer delivery systems. For instance, jasmine EO encapsulated into pectin/chitosan composite nanoparticles has been shown to exhibit anticancer activity approximately 13 times higher than the nonencapsulated EO and enhanced normal cell viability [91].…”

Section: Pharmaceutical Sectormentioning

confidence: 99%

Microencapsulation of Essential Oils by Spray-Drying and Influencing Factors

Nguyen

Dang

et al. 2021

Journal of Food Quality

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Essential oils (EOs) are known as any aromatic oily organic substances which are naturally synthesized in plants. Exhibiting a broad range of biological activities, EOs have played a key role in numerous industries for ages, including pharmaceutical, textile, and food. However, the volatility and high sensitivity to environmental influences pose challenges to the application of EOs on industrial scale. Microencapsulation via the spray-drying method is one of the promising techniques to overcome these challenges, thanks to the presence of wall materials that properly protect the core EOs from oxidation and evaporation. By optimization of key factors related to the infeed emulsion properties and spray-drying process, the encapsulation efficiency and retention of encapsulated EOs could be significantly improved, thus allowing a wide range of EO applications. This review attempts to discuss on different determining factors of the spray-drying process to develop an effective encapsulation formula for EOs. Furthermore, recent applications of encapsulated EOs in the fields of foods, pharmaceuticals, and textile industries are also thoroughly addressed.

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Essential oil loaded pectin/chitosan nanoparticles preparation and optimization via Box–Behnken design against MCF-7 breast cancer cell lines

Abstract: Pec/CS/JO formulated nanocomposite showed a 13-fold increase in potency against cancer cells, whereas cell viability of normal cells wasn't affected.

Cited by 57 publications

References 25 publications

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Evaluation of Antitumor Efficacy of Chitosan-Tamarind Gum Polysaccharide Polyelectrolyte Complex Stabilized Nanoparticles of Simvastatin

Microencapsulation of Essential Oils by Spray-Drying and Influencing Factors

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