Essential Oil from the Leaves of <i>Ajuga iva:</i> Chemical Composition and Antimicrobial Activity

Chouitah, O.; Meddah, B.; Aoues, Abdelkader; Sonnet, Pascal

doi:10.1080/0972060x.2017.1337526

Cited by 14 publications

(12 citation statements)

References 6 publications

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“…Indeed, other studies have reported that phenological stages regulate the secretion of essential oils 12,17 . Previous studies have reported the chemical composition of AIEO 24,25 . These works showed similar chemical composition compared to our findings with some variability concerning the amounts of the major volatile compounds.…”

Section: Resultssupporting

confidence: 86%

“…Biological investigations of A iva extracts showed that this plant exhibited antimicrobial, 19 anti‐parasitic, 20 antidiabetic, 21 anticancer, antioxidant, anti‐hypertension 22 and anti‐inflammatory 23 effects. Moreover, volatile compounds of A iva essential oils (AIEO) have also shown antibacterial, antioxidant, hepatoprotective and antiviral activities against adenovirus type 5, coxsackievirus type B‐3, respiratory syncytial virus type B and herpes simplex virus type 2 1,24‐26 …”

Section: Introductionmentioning

confidence: 99%

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Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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Ajuga iva (A iva) is a medicinal plant used mainly in traditional medicine. This study was aimed to identify the volatile compounds of A iva essential oils (AIEO) at three developmental periods, and to evaluate their pharmacological properties. Chemical volatile compounds were identified by GC/MS analysis. Twenty‐eight volatile components were identified, belonging mainly to oxygenated monoterpenes and hydrocarbons monoterpenes. Carvacrol, octadecane, methyl chavicol were the major volatile components of AIEO at the three phenological stages. FRAP, DPPH and ABTS assays were adopted to estimate the antioxidant effects. AIEO at the vegetative stage exhibited important antioxidant effects with IC50 = 52.43 μg/mL (DPPH), IC50 = 115.22 μg/mL (FRAP), and, IC50 = 143.40 μg/mL (ABTS). The antidiabetic activity was evaluated in vitro by the inhibition of α‐amylase and α‐glucosidase. AIEO at the vegetative stage was the most active as an enzyme inhibitor of α‐amylase (IC50 = 101.727 μg/mL) and α‐glucosidase (IC50 = 86.93 μg/mL). The dermatoprotective effect was investigated by the in vitro inhibition of tyrosinase and elastase activities. AIEO at the vegetative stage showed the lowest IC50 inhibition values against tyrosinase (IC50 = 87.49 μg/mL) and elastase (IC50 = 192.21 μg/mL). Antifungal properties of AIEO were investigated on Trichophyton violaceum, T tonsurans and T mentagrophytes. The three EOs of A iva exhibited important inhibitions of the tested dermatophytes. The findings of this work showed that phenological stages affect significantly the volatile compounds of A iva, and these fluctuations influence mainly the biological properties. Moreover, further investigations concerning in vivo pharmacodynamic and pharmacokinetic investigations as well as clinical trials of these identified compounds could develop antidiabetic, dermatoprotective and anti‐dermatophyte drugs.

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Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Bouyahya

Omari

Belmehdi

et al. 2020

Flavour & Fragrance J

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“…The phytochemical investigation of the extracts derived from different parts of A. iva showed the presence of diverse classes of bioactive secondary metabolites such as flavonoids, steroids, terpenoids, and fatty acids [ 16 ]. Five terpenoids such as ivain I-V were isolated from the diethyl ether extract of the whole plant of A. iva , in addition to 6-desoxyharpagide, 3-8- O -acetylharpagide, 8- O -acetylharpagide, and harpagide.…”

Section: Lamiaceae Species Used For Diabetesmentioning

confidence: 99%

“…In vitro and in vivo biological investigations revealed that the methanolic extract of A. iva has antidiabetic activity [ 16 , 19 ]. A. iva possesses hypoglycaemic and hypolipidemic activities [ 19 ].…”

Section: Lamiaceae Species Used For Diabetesmentioning

confidence: 99%

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Etsassala

Hussein

Nchu

2021

Plants

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Diabetes is one of the most dangerous metabolic disorders, with high rates of mortality worldwide. Since ancient times, medicinal plants have been used in traditional medicine to treat many diseases, including diabetes and its related complications. Plants are widely accepted, affordable, and perceived to have minimal adverse side effects. The Lamiaceae family is a potential source of therapeutic agents for the management of metabolic disorders, including diabetes. Hence, this review paper summarizes the antidiabetic use of Lamiaceae species in folk medicine globally. Furthermore, we present the antidiabetic activities and phytochemical constituents of twenty-three (23) Lamiaceae species and the antidiabetic activity of some notable chemical constituents isolated from some of these Lamiaceae species.

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“…Analysis of the data obtained showed that the age of the respondents varied between 22 and 80 years, with a majority of the age group [41][42][43][44][45][46][47][48][49][50] at 34%. Then come the age groups [51][52][53][54][55][56][57][58][59][60], [31][32][33][34][35][36][37][38][39][40], [21][22][23][24][25][26][27][28][29][30] and finally those over 61, with a rate of 26%, 18.7%, 11.3% and 10% respectively. On the one hand, this could be explained by the ignorance of the traditional medicinal uses of plants by the younger generation.…”

Section: Demographic Featuresmentioning

confidence: 99%

Ethnopharmacological Documentation of Medicinal Plants Used in the Traditional Treatment of Hypertension in Tarfaya Province, Morocco

Idm’hand

Msanda

Chérifi

2019

IJPPE

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The use of plants to treat chronic diseases is part of an ancient Moroccan tradition. This study will present the first relevant documentation on medicinal plants used in the treatment of hypertension in Tarfaya province. This study aimed to collect and document information on medicinal plants traditionally used by the local population of Tarfaya province for the treatment of hypertension. Ethnobotanical surveys were conducted using 150 questionnaires in the study area. Documented data were evaluated using the quantitative ethno-botanical indices of frequency citation (FC) and Relative Frequency of Citation (RFC). The results obtained allowed to inventory 52 species of medicinal plants belonging to 29 families traditionally used against hypertension. The species were rich in diverse chemical constituents. The most cited families are Lamiaceae (9 species), Apiaceae (5 species), Compositae (3 species), Leguminosae (3 species) and Myrtaceae (3 species). Ten plants are reported for the first time as used in the treatment of hypertension. The most cited plant species are Allium sativum (RFC = 0.28), Allium cepa (RFC = 0.2), Olea europaea (RFC = 0.18), Searsia tripartita (RFC = 0.16), Ammodaucus leucotrichus (RFC = 0.15) and Myrtus communis (RFC = 0.15). Leaves were the most used organs. The decoction was the dominant method of preparation. This study showed that the inhabitants of Tarfaya use a wide variety of plants for the treatment of hypertension. This work is a source of information that can serve as a basis for phytochemists and pharmacologists interested in research on plants with antihypertensive effect.

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Essential Oil from the Leaves of Ajuga iva: Chemical Composition and Antimicrobial Activity

Cited by 14 publications

References 6 publications

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Pharmacological investigation ofAjuga ivaessential oils collected at three phenological stages

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Ethnopharmacological Documentation of Medicinal Plants Used in the Traditional Treatment of Hypertension in Tarfaya Province, Morocco

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