Essential oil–cyclodextrin complexes: an updated review

Wadhwa, Geetika; Kumar, Sunil; Chhabra, Lovely; Mahant, Sheefali; Rao, Rekha

doi:10.1007/s10847-017-0744-2

Cited by 114 publications

(59 citation statements)

References 85 publications

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“…In most works, complexes of cinnamon EO and cyclodextrins were processed. Cyclodextrins are natural cyclic oligosaccharides with a truncated cone shape characterised by a hydrophilic external surface and a hydrophobic interior cavity (Figure 2a) [26,75,76]. They are extensively used to form inclusion complexes with essential oils, which are trapped in the hydrophobic cavity, in order to improve EOs bioavailability and stability.…”

Section: Cinnamon Essential Oilmentioning

confidence: 99%

“…The chemical components of essential oils are volatile and susceptible to easy degradation due to temperature, light, oxygen, and moisture. Hence, encapsulating systems, such as microand nano-particles, capsules, droplets, cyclodextrin complexes, and fibres, are required to deliver still-functional EOs to a specific target and in a controlled fashion [24][25][26]. This review analyses the current state of the art on the release of EOs from polymeric fibres produced by electrospinning.…”

Section: Introductionmentioning

confidence: 99%

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Electrospinning of Essential Oils

Mele

2020

Polymers

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The extensive and sometimes unregulated use of synthetic chemicals, such as drugs, preservatives, and pesticides, is posing big threats to global health, the environment, and food security. This has stimulated the research of new strategies to deal with bacterial infections in animals and humans and to eradicate pests. Plant extracts, particularly essential oils, have recently emerged as valid alternatives to synthetic drugs, due to their properties which include antibacterial, antifungal, anti-inflammatory, antioxidant, and insecticidal activity. This review discusses the current research on the use of electrospinning to encapsulate essential oils into polymeric nanofibres and achieve controlled release of these bioactive compounds, while protecting them from degradation. The works here analysed demonstrate that the electrospinning process is an effective strategy to preserve the properties of essential oils and create bioactive membranes for biomedical, pharmaceutical, and food packaging applications.

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Section: Cinnamon Essential Oilmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrospinning of Essential Oils

Mele

2020

Polymers

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“…However, the use of essential oils in many application is restricted due to their drawbacks such as low aqueous solubility, high volatility, low stability and high reactivity. In recent years, there is a growing interest to form inclusion complexes of essential oils and volatile active agents with CDs to eliminate or reduce their drawbacks [27][28][29]. Carvacrol (Fig.…”

Section: Introductionmentioning

confidence: 99%

Fast-dissolving carvacrol/cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activity

et al. 2018

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Carvacrol is a known antioxidant molecule and commonly used in food and cosmetics as a flavor and fragrance agent; however, carvacrol has major issues such as high volatility, low water solubility, and stability. In this study, carvacrol/cyclodextrin inclusion complex fibers (carvacrol/CD-IC fibers) were produced via electrospinning in order to enhance thermal stability, water solubility and shelf-life of carvacrol having antioxidant activity. The phase solubility and computational modeling studies showed that carvacrol can form inclusion complexes with two types of modified CDs, hydroxypropyl-bcyclodextrin (HPbCD) and hydroxypropyl-c-cyclodextrin (HPcCD). The carvacrol/cyclodextrin inclusion complex electrospun fibers (carvacrol/HPbCD-IC fibers and carvacrol/HPcCD-IC fibers) were obtained as free-standing fibrous webs. Although pure carvacrol is highly volatile, the electrospun carvacrol/CD-IC fibers were quite effective to preserve high amount of carvacrol due to the inclusion complexation. In addition, carvacrol/CD-IC fibers have shown higher temperature stability for carvacrol. Moreover, carvacrol/CD-IC fibers showed more effective antioxidant activity as compared to pure carvacrol. The carvacrol/CD-IC fibrous webs have shown fast-dissolving character in water due to the enhanced water solubility of carvacrol/CD-IC and their ultrafine fiber structure. In short, encapsulation of carvacrol in electrospun CD-IC fibrous webs has shown potentials for food and oral care applications due to free-standing and fast-dissolving character along with high water solubility, high temperature stability and enhanced antioxidant by carvacrol/cyclodextrin inclusion complexation.

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“…There are a significant number of CDs however the most common ones are α-, β-, and γ-CDs. Greek letters α-, β-, and γ-designate the number of glucopyranose units in their structure [4][5][6][7]. Due to their cone-shaped hydrophobic cavity, CDs are good candidates to be used as a host for molecule encapsulations to form inclusion complexes (ICs) [8][9].…”

Section: Introductionmentioning

confidence: 99%

Inclusion complexes of β-cyclodextrine with Fe3O4@HA@Ag Part I:Preparation and characterization

et al. 2019

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n this study, the preparation of inclusion complexes according to kneading and physical mixing techniques at 1:1 and 1:2 (guest:host) mass ratios of Fe 3 O 4 @HA@Ag and β-cyclodextrin were studied. Fourier transformed infrared spectroscopy, thermogravimetric analyses and scanning electron microscope analysesof the prepared complexes were carried out. According to the results obtained, it was observed Fe 3 O 4 @HA@Ag especially forms inclusion complex with β-cyclodextrin at a mass ratio of 1:2. In the second part of this study, results related to the use of these inclusion complexes during electrospinning process in order to obtain antibacterial nanowebs, which could potentially be used in medical wounds, will be given.

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Essential oil–cyclodextrin complexes: an updated review

Cited by 114 publications

References 85 publications

Electrospinning of Essential Oils

Electrospinning of Essential Oils

Fast-dissolving carvacrol/cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activity

Inclusion complexes of β-cyclodextrine with Fe3O4@HA@Ag Part I:Preparation and characterization

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