Essential Oil Constituents of<i>Artemisia afra</i>Willd.

Mwangi, Julius; Achola, K. J.; Sinei, Kipruto A.; Lwande, Wilber; Laurent, R.

doi:10.1080/10412905.1995.9698475

Cited by 12 publications

(5 citation statements)

References 2 publications

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“…Bohlmann and Zdero [25] revealed that the roots of A. afra contained isomeric courmarins and five acetylenes, while the aerial parts contained thujone and umbelliferone-derivatives and no acetylenes. Similar variations were reported in the volatile secondary metabolite composition between the leaves [139] and the whole plant [138] of A. afra. The results showed that the oil obtained from the leaves mainly consisted 1,8-cineole (67.4%); while yogomi alcohol (21.6-26.8%) and artemisyl acetate (24.4-32.1%) predominated in the oil extracted from the whole plant.…”

Section: Variation Within Plantssupporting

confidence: 83%

“…The main components of the volatile secondary metabolites in A. afra varied enormously in plants from different geographical regions. The major constituent in Ethiopian oil [138] was artemisyl acetate (24.4-32.1%) while it was 1,8-cineole (67.4%) in Kenyan oil [139]. In Zimbabwean oil, α-and β-thujone (52%) was the major constituent [140] while α-thujone (54.2%) was in South African oil [141].…”

Section: Geographical Variationmentioning

confidence: 99%

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Artemisia afra and Modern Diseases

Patil¹,

Dass²,

Ch³

et al. 2011

J Pharmacogenom Pharmacoproteomics

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The number of hits on the internet based science-specific search engine "Scirus" [23] up to mid July 2011 for the key words and the details thereof are given in Table 1. The significance of genus Artemisia is seen in its number of hits, which is 89,080.The total number of hits appeared for "Artemisia afra" (A. afra) were 885 of which, 5 had no dates. Figure 1 is the graph of 162 publications that appeared in Journal Sources classified and plotted on yearly basis from Jan. 1922 to Nov. 2011 for "A. afra".Only two scientific publications based on laboratory work were found in the literature over a span of half a century, first by Goodson in Jan. 1922 [24] and then second by Bohlman and Zdero in 1972 [25]. Both the papers report the constituent's of A. afra. Goodson investigated if A. afra contained anything that could be regarded as a precursor or a derivative of santonin in consequence of the difficulty of obtaining santonin that was then used as the sole source of anthelmintic. He showed that A. afra contains camphor, a wax-ester probably ceryl cerotate, triacontane, scopoletin and quebrachitol and none which

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Section: Variation Within Plantssupporting

confidence: 83%

Section: Geographical Variationmentioning

confidence: 99%

Artemisia afra and Modern Diseases

Patil¹,

Dass²,

Ch³

et al. 2011

J Pharmacogenom Pharmacoproteomics

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“…Previous investigation of Artemisia oils showed varying compositions. In the oil of A. afra from Kenya, 1, 8-cineole represented 67.4% of the total oil (main component), borneol 5.1% and terpinen-4-ol 6.5% [12]. Ethiopian species growing in Vienna contained yomogi alcohol as the major compound (21.6-26.8%), followed by 1,8-cineole and artemisia alcohol (7.2-8.1% and 3.5-3.7%, respectively) [13].…”

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confidence: 99%

Composition and Antibacterial Activity of Essential Oils of Artemisia Fragrans Willd. Leaves and Roots from Iran

Shafaghat

Noormohammadi

Zaifizadeh

2009

Natural Product Communications

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Hydrodistillation of leaves and roots of Artemisia fragrans Willd. (Asteraceae) yielded 0.9% and 0.1 %( v/w) essential oils, respectively. GC/MS analysis allowed identification of 19 components, which made up 91.1% of the total oil from the leaves, while only 9 compounds (93.8%) were identified in the roots. The main components of the leaf oil were chrysanthenon (23.8%), 1, 8-cineole (23.7%), β-caryophyllene (9.6%), p-cymene (7. 7%), filifolide-A (5.7%) and filifolone (5.7%). In the root oil, the main constituents were camphor (67.0%) and camphene (16.9%). Antibacterial activity was tested against Grampositive and Gram-negative bacteria using the agar diffusion method. Activity was observed against two Gram-positive and one Gram-negative bacteria.

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“…The same major compound was found by Josphat et al when analysing the essential oil from Artemisia afra by GCMS. The major constituents were 1, 8cineole (67.4%), terpinen-4-ol (6.5%) and borneol (5.1%) [14]. The medicinal effect attributed to that plant can be because of the presence of all those active compounds.…”

Section: Gcms Of Artemisia Afra Extractsmentioning

confidence: 98%

Expression of The Fab Enzymes (Fab I And Fab Z) From Plasmodium Falciparum After Exposure To Artemisia Afra Plant Extracts And Drugs Screening

Kane¹,

Kyama²,

Ngángá³

et al. 2021

Preprint

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Background:The emergence and spread of drug resistance of the malaria parasite to the main treatment emphasis the need to develop new antimalarial drugs. In this context, the fatty acid biosynthesis (FAS_II) pathway of the malaria parasite is one of the ideal target due to its crucial role in parasite survival.Method:We report in this study the expression and the affinity binding of two Fab enzymes (FabI and FabZ) after exposure of the parasite using different extracts of the Artemisia afra and after a virtual screening with the different plant compounds. Two differents strains of Plasmodium falciparum was used: W2 (CQ_resistant) and D6 (CQ_sensitive) with a parasiteamia of 4%. The parasites were exposed during 2 days to different Artemisia afra extracts . Gene expression was done to determine the level of expression of the fab enzymes after treatments. A GCMS was run to determine the different compounds of the plant extracts following by a virtual screening between the fab enzymes and the active compounds using Pyrex. Result:The results showed different expression patterns of the Fab enzymes. FabI was downregulated in the W2 and D6 strains by the ethanolic extract in a higher rate for W2. Hexane and DCM extracts increased the production of FabI respectively in W2 and D6 strains. A different expression pattern was observed for Fab Z. The expression of FabZ in the W2 strain were all upregulated. The enzyme was downregulated only in the D6 strain when exposed to the ethanolic and hexane extracts of the plant. After virtual screening, a lot of compounds were found to interact with the two fab enzymes. Hits compounds for FabI and FabZ with high biding energy were detected. 11alpha-Hydroxyprogesterone and Aspidospermidin-17-ol were found to have high binding energy with FabI respectively (-10.7 kcal/mol; -10.2kcal/mol). Fab Z was having also a high affinity with the two following hits compounds: 11alpha-Hydroxyprogesterone (-10 kcal/mol) and Thiourea (-8.4 Kcal/mol). Conclusion:The study showed that Artemisia afra is a big source of antimalarial drugs, and could act not only as a curative but also as prophylactic due to its effects on the Fab enzymes.

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Essential Oil Constituents ofArtemisia afraWilld.

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Cited by 12 publications

References 2 publications

Artemisia afra and Modern Diseases

Artemisia afra and Modern Diseases

Composition and Antibacterial Activity of Essential Oils of Artemisia Fragrans Willd. Leaves and Roots from Iran

Expression of The Fab Enzymes (Fab I And Fab Z) From Plasmodium Falciparum After Exposure To Artemisia Afra Plant Extracts And Drugs Screening

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