Essential Oil Constituents of Angelica glauca Edgew. Roots: An Endangered Species from Uttarakhand Himalaya (India)

Purohit, Vijay Kant; Andola, Harish Chandra; Haider, S. Zafar; Tiwari, Deepti; Bahuguna, Yateesh Mohan; Gairola, Keshav Chandra; Arunachalam, A.

doi:10.1007/s40009-015-0395-z

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…Agnihotri et al [ 18 ] investigated the composition of EO from fresh aerial parts of A. glauca growing in Kashmir valley in higher Himalaya (India), and found that α-phellandrene (13.5%), trans -carveol (12.0%), and β-pinene (11.7%) were the major components. The EOs from the roots of A. glauca collected from two alpine Himalayan locations in Uttarakhand (India) highly contain (Z) -ligustilide (40.6–53.0%) and (Z) -butylidene phthalide (20.7–32.8%) [ 25 ].…”

Section: The Chemical Composition Of Essential Oils Of Amentioning

confidence: 99%

A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

et al. 2017

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A number of Angelica species have been used in traditional systems of medicine to treat many ailments. Especially, essential oils (EOs) from the Angelica species have been used for the treatment of various health problems, including malaria, gynecological diseases, fever, anemia, and arthritis. EOs are complex mixtures of low molecular weight compounds, especially terpenoids and their oxygenated compounds. These components deliver specific fragrance and biological properties to essential oils. In this review, we summarized the chemical composition and biological activities of EOs from different species of Angelica. For this purpose, a literature search was carried out to obtain information about the EOs of Angelica species and their bioactivities from electronic databases such as PubMed, Science Direct, Wiley, Springer, ACS, Google, and other journal publications. There has been a lot of variation in the EO composition among different Angelica species. EOs from Angelica species were reported for different kinds of biological activities, such as antioxidant, anti-inflammatory, antimicrobial, immunotoxic, and insecticidal activities. The present review is an attempt to consolidate the available data for different Angelica species on the basis of major constituents in the EOs and their biological activities.

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Section: The Chemical Composition Of Essential Oils Of Amentioning

confidence: 99%

A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

et al. 2017

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“…Angelica glauca Edgew (syn: Angelica nuristanica ; family: Apiaceae; common names: “Chora”, “Gandhrayan”, and “Smooth angelica”) is an important medicinal and aromatic herb that is endemic to the IHR. It is an endangered perennial diploid (2n = 22) herb with an extensively larger genome size (11.7 Gb), and it is distributed throughout the Western Himalayan regions at an altitudinal range of 2000–3800 m above sea level (amsl) [ 7 , 8 , 9 , 10 ]. The plant is glabrous, tall, and erect, having 1–3 pinnately compound leaves, with a thick fistular stem and long conic roots.…”

Section: Introductionmentioning

confidence: 99%

“…The active accumulations of phthalide (butylidene phthalide and ligustilide), ferulic acid, and terpenoids (nerolidol, menthol, and carvone) have been traditionally used for the treatment of various disorders (cardiac, renal, digestive, pulmonary, rheumatism, menorrhea, cancer, and inflammation), and they have been used widely in aromatherapy [ 8 , 12 , 13 , 14 , 15 ]. Phthalide biosynthesis involves either the condensation of malonyl CoA with acetyl-CoA or propionyl-CoA molecules, followed by the SAM-methylation-mediated production of tetraketide intermediate.…”

Section: Introductionmentioning

confidence: 99%

Spatial Genomic Resource Reveals Molecular Insights into Key Bioactive-Metabolite Biosynthesis in Endangered Angelica glauca Edgew

Devi

Seth

Masand

et al. 2022

IJMS

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Angelica glauca Edgew, which is an endangered medicinal and aromatic herb, is a rich source of numerous industrially important bioactive metabolites, including terpenoids, phenolics, and phthalides. Nevertheless, genomic interventions for the sustainable utilization and restoration of its genetic resources are greatly offset due to the scarcity of the genomic resources and key regulators of the underlying specialized metabolism. To unravel the global atlas of the specialized metabolism, the first spatial transcriptome sequencing of the leaf, stem, and root generated 109 million high-quality paired-end reads, assembled de novo into 81,162 unigenes, which exhibit a 61.53% significant homology with the six public protein databases. The organ-specific clustering grouped 1136 differentially expressed unigenes into four subclusters differentially enriched in the leaf, stem, and root tissues. The prediction of the transcriptional-interactome network by integrating enriched gene ontology (GO) and the KEGG metabolic pathways identified the key regulatory unigenes that correspond to terpenoid, flavonoid, and carotenoid biosynthesis in the leaf tissue, followed by the stem and root tissues. Furthermore, the stem and root-specific significant enrichments of phenylalanine ammonia lyase (PAL), cinnamate-4-hydroxylase (C4H), and caffeic acid 3-O-methyltransferase (COMT) indicate that phenylalanine mediated the ferulic acid biosynthesis in the stem and root. However, the root-specific expressions of NADPH-dependent alkenal/one oxidoreductase (NADPH-AOR), S-adenosyl-L-methionine-dependent methyltransferases (SDMs), polyketide cyclase (PKC), and CYP72A15 suggest the “root” as the primary site of phthalide biosynthesis. Additionally, the GC-MS and UPLC analyses corresponded to the organ-specific gene expressions, with higher contents of limonene and phthalide compounds in the roots, while there was a higher accumulation of ferulic acid in the stem, followed by in the root and leaf tissues. The first comprehensive genomic resource with an array of candidate genes of the key metabolic pathways can be potentially utilized for the targeted upscaling of aromatic and pharmaceutically important bioactive metabolites. This will also expedite genomic-assisted conservation and breeding strategies for the revival of the endangered A. glauca.

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“…Z and E-ligustilide, Z and E-butylidene phthalide, caryophyllene oxide, thujene, terpinene, nerolidol, bisabolene, 6 types of coumurins and 23 other compounds have been isolated from essential oil of Angelica species. 23,[25][26][27][28] Different biological activities like anti-oxidant, anti-seizure, cytotoxicity, Anti-aflatoxigenic, nicotine sensitizaiton, anti-inflammatory, mosquito repellent etc., have been reported in different species of Angelica. 28 Root extract of A. archangelica L. showed potent antimicrobial activities against four fungal and five bacterial pathogens.…”

Section: Introductionmentioning

confidence: 99%

Methanolic Extract of Angelica glauca Edgew Root and Stem: A Possible Component of Herbal Medicines against Respiratory Infections

Arya¹,

Mehta²,

Maurya³

2021

IJPER

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Plants are identified to produce a variety of compounds to protect themselves against a diversity of pathogens. This study assessed the antibacterial, antioxidant potential and phytochemical screening of medicinal plant Angelica glauca (Choru) root and stem extracts against respiratory tract pathogens i.e., Staphylococcus aureus MTCC 1144, Streptococcus pneumoniae MTCC 655, Streptococcus pyogenes MTCC 442, Pseudomonas aeruginosa MTCC 2474 and Klebsiella pneumoniae MTCC 4030. The plant material was collected from Tungnath 3,800m amsl of Garhwal Himalaya. Root and stem of the plants were washed, shade dried, grinded into fine powder and extracted in the organic solvents of different polarity (petroleum ether, chloroform, methanol and water). Antibacterial activities of prepared extracts were assayed using agar well diffusion and two-fold serial dilution method of MIC determination. Antioxidant potential was determined using DPPH assay and phytochemical analysis was performed using qualitative methods for different phytochemicals. Experimental outcomes revealed maximum antibacterial and antioxidant activity of methanol extract; also the maximum groups of phytochemicals were present in the methanolic extract. The methanol extract produced ZOIs of 11.0±0.54mm to 30.3±1.58mm diameters and MICs ranges were recorded between 3.12 mg/ml to 25 mg/ml against all the tested bacteria. Alkaloids, flavonoids, glycosides, tannins, steroids and saponins were present in the extracts of A. glauca. This study favors a good response towards using A. glauca as natural antioxidant in herbal medicines, either in pure form or as supplement with other herbal formulations already available in the market, to enhance their potential against respiratory tract diseases. In the present COVID-19 pandemic situation, use of A. glauca can be beneficial, as it's methanolic extract showed promising antibacterial activity against bacterial pathogens of human respiratory tract.

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Essential Oil Constituents of Angelica glauca Edgew. Roots: An Endangered Species from Uttarakhand Himalaya (India)

Cited by 13 publications

References 13 publications

A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

A Review of the Composition of the Essential Oils and Biological Activities of Angelica Species

Spatial Genomic Resource Reveals Molecular Insights into Key Bioactive-Metabolite Biosynthesis in Endangered Angelica glauca Edgew

Methanolic Extract of Angelica glauca Edgew Root and Stem: A Possible Component of Herbal Medicines against Respiratory Infections

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