Essential oil composition of the aerial parts of <i>Cachrys sicula</i> L.

Palá-Paúl, Jesús; Velasco‐Negueruela, Arturo; Pérez‐Alonso, María José; Sanz, J.

doi:10.1002/ffj.1042

Cited by 8 publications

(6 citation statements)

References 8 publications

(5 reference statements)

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“…De Leo and coworkers isolated the three coumarins 8-hydroxymethylpsoralen, sprengelianin, and oxypeucedanin from the dried leaf extract [ 15 ]. Palá-Paúl et al [ 16 ] also investigated the chemical composition of the essential oil of C. sicula aerial parts and reported the presence of many terpenes, while Pinar [ 17 ] isolated the diamine N-N′-di-o-tolylethylendiamine. Some photodermatitis agents have been identified in C. libanotis [ 18 ] and the presence of various terpenes have been detected in its essential oil [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells

Marrelli

Perri

Amodeo

et al. 2021

Plants

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Photochemotherapy is one of the most interesting current therapeutic approaches for the treatment of melanoma. Different classes of naturally occurring phytochemicals demonstrated interesting photoactive properties. The aim of this study was to evaluate the photocytotoxic potential of two Cachrys species from Southern Italy: C. sicula and C. libanotis (Apiaceae). The enriched-coumarin extracts were obtained from aerial parts through both traditional maceration and pressurized cyclic solid-liquid (PCSL) extraction using Naviglio extractor®. Qualitative and quantitative analyses of furanocoumarins were performed with GC-MS. The photocytotoxic effects were verified on C32 melanoma cells irradiated at a dose of 1.08 J/cm2. The apoptotic responses were also assessed. Moreover, phenolic content and the in vitro antioxidant potential were estimated. Xanthotoxin, bergapten, and isopimpinellin were identified. All the samples induced concentration-dependent photocytotoxic effects (IC50 ranging from 3.16 to 18.18 μg/mL). The C. libanotis sample obtained with Naviglio extractor® was the most effective one (IC50 = 3.16 ± 0.21 μg/mL), followed by C. sicula sample obtained with the same technique (IC50 = 8.83 ± 0.20 μg/mL). Both Cachrys samples obtained through PCSL induced up-regulation of apoptotic signals such as BAX (Bcl2-associated X protein) and PARP (poly ADP-ribose polymerase) cleavage. Moreover, these samples proved to be more photoactive, giving a greater upregulation of p21 protein in the presence of UVA radiation. Obtained results suggest that investigated species could be promising candidates for further investigations aimed to find new potential drugs for the photochemotherapy of skin cancer.

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Section: Introductionmentioning

confidence: 99%

Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells

Marrelli

Perri

Amodeo

et al. 2021

Plants

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“…Phytochemical investigation of C. sicula has also dealt with identification of various furanocoumarins, among which are isoimperatorin, imperatorin, bergapten, xanthotoxin, isopimpinellin, tert-o-methylheraclenol, (-)-prantschimgin, (-)-sprengelianin, ulopterol and saxalin (7). Palà-Paúl et al (8) also investigated chemical composition of essential oils of the aerial parts of C. sicula, and identified many terpenes, while Pinar (9) isolated diamine N-N¢-di-o-tolylethylendiamine. Phytochemical composition of C. libanotis L. was also investigated; 5-methoxypsoralen, 8-methoxypsoralen, 5,8-dimethoxypsoralen from the alcoholic extract (10), and various terpenes from the essential oil (11) were identified.…”

Section: Introductionmentioning

confidence: 99%

Cachrys pungens Jan inhibits human melanoma cell proliferation through photo‐induced cytotoxic activity

Menichini¹,

Alfano²,

Provenzano³

et al. 2011

Cell Proliferation

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Plant-derived natural compounds are an important source for development of cancer-fighting drugs. This study has demonstrated strong phototoxic activity of the coumarin fraction of C. pungens, a plant which, to our knowledge, has never been studied before. This investigation offers a new perspective for developing other formulations potentially useful in photodynamic therapy for treatment of non-melanoma skin cancers as well as melanomas.

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“…The classification of the Cachrys genus has been somewhat confused. According to Tutin (1968), this genus included also Prangos Lindley and Hippomarathrum Link, while in 1872, Boissier had classified them into three different genera [ 15 , 16 , 17 ].…”

Section: Taxonomy Of the Cachrys Genusmentioning

confidence: 99%

Cachrys L. Genus: A Comprehensive Review on Botany, Phytochemistry and Biological Properties

Musolino

Perri

Conforti

et al. 2023

Plants

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The Cachrys L. genus belongs to the Apiaceae family and it is widely distributed in the Mediterranean basin, with plant species being endemic to southern Europe, Asia, and northern Africa. Different studies, focused on the phytochemical composition of Cachrys spp. and the biological properties of their phytocomplexes, have been reported. These works mostly focused on the essential oils obtained from these plants, and pointed out that Cachrys species are a rich source of coumarins, mainly furanocoumarins. Other phytochemicals, such as terpenes, fatty acids, phytosterols, and flavonoids have been also identified. Moreover, a number of biological properties such as antioxidant, antimicrobial, anti-inflammatory, cytotoxic, and photocytotoxic effects have been assessed. Nevertheless, a review of the chemical and pharmacological properties of this genus is not available in the literature. The aim of this paper is to provide an overview of the reports concerning the identified phytochemicals and the biological effects reported for Cachrys spp., and to offer a comprehensive understanding of the potential of this genus as a source of bioactive compounds. The current taxonomy, the traditional uses, and the toxicological aspects of plants belonging to this genus are also reported, and the future research directions are discussed.

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Essential oil composition of the aerial parts of Cachrys sicula L.

Cited by 8 publications

References 8 publications

Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells

Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells

Cachrys pungens Jan inhibits human melanoma cell proliferation through photo‐induced cytotoxic activity

Cachrys L. Genus: A Comprehensive Review on Botany, Phytochemistry and Biological Properties

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