Essential oil composition of Polylophium Involucratum and evaluation of antioxidant capacity of seeds ethanolic extracts by DSC

Mohammadi, Nima; Ostovar, Nikoo

doi:10.1016/j.focha.2022.100066

Cited by 11 publications

(5 citation statements)

References 34 publications

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“…It was revealed that several bioactive compounds exist in this extract, including methyl oleate, isopropyl stearate, and 3,4-dihydroxy-1,6-bis-(3methoxy-phenyl)-hexa-2,4-diene-1,6-dione [54,[56][57][58]. There is evidence that such compounds contribute to the observed antimicrobial and antioxidant properties [31,50,[52][53][54][55]. Furthermore, human breast cancer cells (MCF-7) were found to be cytotoxic in a dosedependent manner, while normal fibroblast cells (L929) were not affected.…”

Section: Molecular Docking Analysismentioning

confidence: 94%

“…Extracts from these plants showed significant antibacterial activity against Gram-positive bacteria, which is crucial given the rise in antibiotic resistance [14,[43][44][45][46][47][48]. These extracts may serve as natural sources of antioxidants based on their antioxidant activity [31,40,[49][50][51][52][53][54][55]. It was revealed that several bioactive compounds exist in this extract, including methyl oleate, isopropyl stearate, and 3,4-dihydroxy-1,6-bis-(3methoxy-phenyl)-hexa-2,4-diene-1,6-dione [54,[56][57][58].…”

Section: Molecular Docking Analysismentioning

confidence: 99%

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Assessing Spectral Analysis of Phytoconstituents and Their In Silico Interactions with Target Proteins in Plant Seed Extracts

Babu,

Ahamed,

Paul

et al. 2023

Plants

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The pharmacological and preventive attributes of extracts from vegetable seeds have garnered widespread recognition within the scientific community. This study systematically assessed the in vitro antibacterial, antioxidant, and anti-breast cancer properties of phytochemicals present in various solvent-based vegetable seed extracts. We also conducted molecular docking simulations to ascertain their interactions with specific target proteins. Besides, nine distinct chemical constituents were identified using gas chromatography-mass spectrometry (GCMS). Remarkably, the ethyl acetate extract exhibited robust inhibitory effects against Gram-positive and Gram-negative bacterial strains. Furthermore, its capacity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging was found to be noteworthy, with an IC50 value of 550.82 ± 1.7 µg/mL, representing a scavenging efficiency of 64.1 ± 2.8%. Additionally, the ethyl acetate extract demonstrated significant hydrogen peroxide (H2O2) scavenging activity, with a maximal scavenging rate of 44.1 ± 1.70% (IC50) at a concentration of 761.17 ± 1.8 µg/mL. Intriguingly, in vitro cytotoxicity assays against human breast cancer (MCF-7) cells revealed varying levels of cell viability at different extract concentrations, suggesting potential anticancer properties. Importantly, these ethyl acetate extracts did not display toxicity to L929 cells across the concentration range tested. Subsequently, we conducted in-silico molecular docking experiments utilizing Discovery Studio 4.0 against the c-Met kinase protein (hepatocyte growth factor; PDB ID: 1N0W). Among the various compounds assessed, 3,4-Dihydroxy-1,6-bis-(3-methoxy-phenyl)-hexa-2,4-diene-1,6-dione exhibited a notable binding energy of −9.1 kcal/mol, warranting further investigation into its potential anticancer properties, clinical applications, and broader pharmacological characteristics.

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Section: Molecular Docking Analysismentioning

confidence: 94%

Section: Molecular Docking Analysismentioning

confidence: 99%

Assessing Spectral Analysis of Phytoconstituents and Their In Silico Interactions with Target Proteins in Plant Seed Extracts

Babu,

Ahamed,

Paul

et al. 2023

Plants

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“…Therefore, the presence of natural antioxidants in Neltuma ruscifolia extracts enhanced the oxidative stability of marigold oil. Some authors also found that P. Involucratum extracts prevented sheep sebum oxidation [46]. Additionally, it has been reported that natural antioxidants from Inca mint leaves had a better antioxidant effect than TBHQ in soybean oil during frying, significantly improving the oxidative stability of soybean oil during frying [47].…”

Section: Antioxidant Capacity (Ac)mentioning

confidence: 98%

Antioxidant and antiglycant properties of different milling fractions of Neltuma ruscifolia, an underutilized species

Seling,

Rivero,

Busch

et al. 2024

Preprint

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Within the group of neglected and underutilized species (NUS) is Neltuma ruscifolia (formerly Prosopis), belonging to the family Fabaceae (or Leguminosae), commonly known as carob trees but unlike other species, it does not have an established or formally defined commercial value. The objective of this study is to evaluate the antioxidant and antiglycant properties, as well as to identify associated bioactive compounds, in extracts derived from different extraction methods (ultrasound and agitation) and grinding fractions of pods of Neltuma ruscifolia, a NUS species. The results showed that the residue fraction extracted by high-intensity ultrasound exhibited the highest bioactivity. Ultrasonic-assisted extraction allowed polyphenolic compounds such as hydroxybenzoic and ellagic acids to be obtained that did not appear with stirring. Other polyphenols (such as chrysin, rutin, kaempferol and cinnamic, coumaric, protocatechuic, ellagic and caffeic acids) were highly related to the bioactivity. This study lays the foundation for the future development of antioxidant/antiglycant additives derived from Neltuma ruscifolia, diversifying NUS range of natural additives and aligning with the Sustainable Development Goals (SDGs) to safeguard biodiversity, local resources and the planet.

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“…Samples with high initiation temperature have higher stability. Similarly, heating rate is another indicator of susceptibility [47]. The essential oil of C. limetta Risso, has higher oxidative stability since its onset temperature was the highest (58.38°C), followed by the EO of C. sinensis (49.44°C), C. limetta sp.…”

Section: Thermal Behavior Of the Essential Oils (Dsc)mentioning

confidence: 99%

Characterization of Essential Oils from the Skin of Citrus limetta Risso, Citrus limetta Sp., Citrus reticulata and Citrus sinensis Grown in Northeastern Peru

Vasquez-Gomez,

Mori-Mestanza,

Idrogo-Vasquez

et al. 2023

Preprint

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The revaluation of agri-food waste to provide consumers with bioactive compounds for a healthy and environmentally sustainable diet is growing exponentially in society. In the present work, the chemical and physical properties of essential oils (EO) extracted from the peels of four citrus fruits grown and commercialized in Amazonas, Peru: lime (Citrus limetta Risso), sweet lemon (Citrus limetta sp.), mandarin (Citrus reticulata) and orange (Citrus sinensis) were determined. The essential oils were extracted using green solvent and then their antioxidant capacity was determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) free radical scavenging technique; the total phenolic content using Folin Ciocalteu's reagent. Total flavonoids, refractive index, density, specific heat capacity, Ramam mapping and main phenolic compounds were also determined by liquid chromatography (UHPLC-DAD). It was found that lime and mandarin essential oils had higher antioxidant capacity (1592.38 and 1216.13 μmol TE/g) and higher total phenolic content (680.78 and 420.28 mg AGE/g); while sweet lemon peel essential oil had higher total flavonoid content (23.18 mg QE/g). Given their characteristics, these essential oils have a high potential for use in the food and/or pharmaceutical industry.

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Essential oil composition of Polylophium Involucratum and evaluation of antioxidant capacity of seeds ethanolic extracts by DSC

Cited by 11 publications

References 34 publications

Assessing Spectral Analysis of Phytoconstituents and Their In Silico Interactions with Target Proteins in Plant Seed Extracts

Assessing Spectral Analysis of Phytoconstituents and Their In Silico Interactions with Target Proteins in Plant Seed Extracts

Antioxidant and antiglycant properties of different milling fractions of Neltuma ruscifolia, an underutilized species

Characterization of Essential Oils from the Skin of <em>Citrus limetta</em> Risso, <em>Citrus limetta</em> Sp., <em>Citrus reticulata</em> and <em>Citrus sinensis</em> Grown in Northeastern Peru

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