Essential Intracrine Androgenic Action in Lung Development for Both Sexes

Sallon, C.; Provost, Pierre R.; Leblanc, D.R.; Soulet, Denis; Tremblay, Yves

doi:10.1016/j.jsbmb.2018.06.012

Cited by 5 publications

(7 citation statements)

References 34 publications

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“…On the other hand, fibroblasts expressing 17β-HSD type 2 ( 37 ) inactivates androgens ( 36 ). Finally, removing all androgen response in the cells with flutamide causes alveolar simplification ( 45 ), and the alveolar impairment cannot be reversed with the administration of exogenous DHT, because the specific enzymatic machinery has been bypassed.…”

Section: Discussionmentioning

confidence: 99%

“…If removing androgen response is deleterious to the lung, adding them should reverse this effect. Surprisingly, mice exposed to 80% oxygen then treated with exogenous DHT, had similar morphogenic parameters as mice treated with flutamide alone ( 45 ). At 21% oxygen the mice treated with DHT still showed alveolar simplification compared to the control mouse.…”

Section: Summary Of Datamentioning

confidence: 95%

“…Indeed, at 21% oxygen the relative frequency of closed areas under 1,000 μm ( 2 ) decreased and the ones over 2,500 μm ( 2 ) increased. The mice exposed to hyperoxia showed the most dramatic alveolar simplification ( 45 ). The absence of androgen action does not restore the structure of the lung, this supports a positive role for androgens in lung.…”

Section: Summary Of Datamentioning

confidence: 99%

See 2 more Smart Citations

Neonatal Lung Diseases: A Clinical Potential for Sex Steroids and a Novel Intracrine Organ

Tremblay

Morin-Labbé²

2021

Front. Med.

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Section: Discussionmentioning

confidence: 99%

Section: Summary Of Datamentioning

confidence: 95%

Section: Summary Of Datamentioning

confidence: 99%

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Neonatal Lung Diseases: A Clinical Potential for Sex Steroids and a Novel Intracrine Organ

Tremblay

Morin-Labbé²

2021

Front. Med.

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“…Androgens are reported to be modulatory to the development of normal lung in both sexes: in both male and female mice, after addition of exogenous androgens subsequent lung structure and morphologies were altered, whilst the addition of anti-androgens resulted in opposing phenotypes [ 8 ]. In these studies, the addition of exogenous oestrogens had no effect in either sex, whilst anti-oestrogens had a minor effect upon lung morphology.…”

Section: Srs In the Lungmentioning

confidence: 99%

Roles of steroid receptors in the lung and COVID-19

Leach

Brooke

Bevan

2021

Essays in Biochemistry

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COVID-19 symptoms and mortality are largely due to its devastating effects in the lungs. The disease is caused by the SARS (Severe Acute Respiratory Syndrome)-CoV-2 coronavirus, which requires host cell proteins such as ACE2 (angiotensin-converting enzyme 2) and TMPRSS2 (transmembrane serine protease 2) for infection of lung epithelia. The expression and function of the steroid hormone receptor family is important in many aspects that impact on COVID-19 effects in the lung – notably lung development and function, the immune system, and expression of TMPRSS2 and ACE2. This review provides a brief summary of current knowledge on the roles of the steroid hormone receptors [androgen receptor (AR), glucocorticoid receptor (GR), progesterone receptor (PR), mineralocorticoid receptor (MR) and oestrogen receptor (ER)] in the lung, their effects on host cell proteins that facilitate SARS-CoV-2 uptake, and provides a snapshot of current clinical trials investigating the use of steroid receptor (SR) ligands to treat COVID-19.

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“…Studies on steroids have not been restricted to glucocorticoids, where one study has also assessed the impact of endogenous androgen (using flutamide) and estrogen (using fulvestrant), as well as exogenous androgen (dihydrotesterone) and estrogen (17␤-estradiol) on alveolarization (503). In that study, endogenous androgen was documented to play an intracrine role in alveolarization in both sexes, where exogenous androgen was deleterious to alveolarization under hyperoxia exposure.…”

Section: Steroidsmentioning

confidence: 99%

Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

Lignelli

Palumbo

Myti

et al. 2019

American Journal of Physiology-Lung Cellular and Molecular Phys

109

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Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in preterm infants. A key histopathological feature of BPD is stunted late lung development, where the process of alveolarization—the generation of alveolar gas exchange units—is impeded, through mechanisms that remain largely unclear. As such, there is interest in the clarification both of the pathomechanisms at play in affected lungs, and the mechanisms of de novo alveoli generation in healthy, developing lungs. A better understanding of normal and pathological alveolarization might reveal opportunities for improved medical management of affected infants. Furthermore, disturbances to the alveolar architecture are a key histopathological feature of several adult chronic lung diseases, including emphysema and fibrosis, and it is envisaged that knowledge about the mechanisms of alveologenesis might facilitate regeneration of healthy lung parenchyma in affected patients. To this end, recent efforts have interrogated clinical data, developed new—and refined existing—in vivo and in vitro models of BPD, have applied new microscopic and radiographic approaches, and have developed advanced cell-culture approaches, including organoid generation. Advances have also been made in the development of other methodologies, including single-cell analysis, metabolomics, lipidomics, and proteomics, as well as the generation and use of complex mouse genetics tools. The objective of this review is to present advances made in our understanding of the mechanisms of lung alveolarization and BPD over the period 1 January 2017–30 June 2019, a period that spans the 50th anniversary of the original clinical description of BPD in preterm infants.

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Essential Intracrine Androgenic Action in Lung Development for Both Sexes

Cited by 5 publications

References 34 publications

Neonatal Lung Diseases: A Clinical Potential for Sex Steroids and a Novel Intracrine Organ

Neonatal Lung Diseases: A Clinical Potential for Sex Steroids and a Novel Intracrine Organ

Roles of steroid receptors in the lung and COVID-19

Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

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