Essential Fatty Acids Status in Infants and Children with Chronic Liver Disease

Abdel-Ghaffar, Tawhida Yassin; Amin, Mariam Maged; Rasheed, Mehmoodur; Fouad, Hanan

doi:10.3164/jcbn.33.1

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Children with CLD are at risk for essential fatty acid (EFA) deficiency (linoleic and linolenic acids), resulting from a combination of malabsorption and decreased intake of these EFAs. Deficiency of EFAs results in growth impairment, a dry scaly rash, thrombocytopenia, and impaired immune function 19 . Accordingly, linoleic acid levels and plasma triene–tetraene ratio should be measured in a cholestatic child with poor growth to evaluate for EFA deficiency and subsequently the need for supplementation.…”

Section: Pathophysiology Of Malnutrition In Children With Liver Diseasementioning

confidence: 99%

Role of Nutrition in Pediatric Chronic Liver Disease

2011

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Section: Pathophysiology Of Malnutrition In Children With Liver Diseasementioning

confidence: 99%

Role of Nutrition in Pediatric Chronic Liver Disease

2011

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“…In a study of hepatectomized dogs, relative serum concentrations of arachidonic acid were reduced and associated with impaired arachidonic acid synthesis 84 . Likewise, humans with various liver diseases have reduced arachidonic and polyunsaturated fatty acids, such as linoleic or linolenic acid, likely due to impaired liver metabolism and shunting 79 , 85 , 86 . While there was no observed difference in relative concentrations of linoleic acid in any group in the present study, dogs with cPSS and HLEA showed lower relative concentrations of arachidonic acid, which was most apparent in dogs with cPSS (Fig.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic serum abnormalities in dogs with hepatopathies

Imbery

Dieterle

Ottka

et al. 2022

Sci Rep

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Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic shunts (cPSS, n = 24) or high serum liver enzyme activities (HLEA, n = 25) compared to control dogs (n = 64). A validated targeted proton nuclear magnetic resonance spectroscopy platform was used to assess 123 parameters. Principal component analysis of the serum metabolome demonstrated distinct clustering among individuals in each group, with the cluster of HLEA being broader compared to the other groups, presumably due to the wider spectrum of hepatic diseases represented in these samples. While younger and older adult control dogs had very similar metabolomic patterns and clusters, there were changes in many metabolites in the hepatopathy groups. Higher phenylalanine and tyrosine concentrations, lower branched-chained amino acids (BCAAs) concentrations, and altered fatty acid parameters were seen in cPSS dogs compared to controls. In contrast, dogs with HLEA had increased concentrations of BCAAs, phenylalanine, and various lipoproteins. Machine learning based solely on the metabolomics data showed excellent group classification, potentially identifying a novel tool to differentiate hepatopathies. The observed changes in metabolic parameters could provide invaluable insight into the pathophysiology, diagnosis, and prognosis of hepatopathies.

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