Essential Fatty Acids, Prostaglandins, and Nonsteroidal Antiinflammatory Agents: Physiological and Behavioral Interactions

The present study was designed to examine whether the prostaglandin (PG) synthesis inhibitor indomethacin (INDO) could antagonize the anxiolytic effects of ethanol (EtOH) in the elevated plus-maze test of anxiety. EtOH (1.6 g/kg) significantly increased the percentage of open arm entries and time spent on the open arms in both inbred C57BL/6J and outbred CD-1 mouse strains. However, this anxiolytic effect of EtOH was not significantly antagonized by pretreatment with INDO (5 and 10 mg/kg) in either strain. EtOH also significantly increased total arm entries in CD-1 mice, but not in the C57BL/6J strain. These data from C57BL/6J mice indicate that the low-dose stimulant properties of EtOH can be dissociated from the anxiolytic action of the drug in the plus-maze task. Finally, although INDO did not antagonize the stimulant effect of EtOH in the plus-maze task (in CD-1 mice), it did attenuate EtOH-induced stimulation of locomotor activity in an open-field arena. Taken together, these results suggest some specificity with regard to the role of PGs in mediating (or modulating) the neurobehavioral actions of EtOH, and further support the notion that the anxiolytic and stimulant effects of EtOH may be mediated by different mechanisms.

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Prostaglandins in cerebrospinal fluid of healthy human volunteers, abstinent alcoholics and rhesus monkeys

Yergey¹,

Karanian²,

Salem³

et al. 1989

Prostaglandins

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Essential Fatty Acids, Prostaglandins, and Nonsteroidal Antiinflammatory Agents: Physiological and Behavioral Interactions

Cited by 5 publications

References 28 publications

Role of prostaglandins of the gastric mucosa in ulcer development in cirrhosis of the liver

Role of prostaglandins of the gastric mucosa in ulcer development in cirrhosis of the liver

Indomethacin does not antagonize the anxiolytic action of ethanol in the elevated plus-maze

Prostaglandins in cerebrospinal fluid of healthy human volunteers, abstinent alcoholics and rhesus monkeys

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