Essential fatty acids in the plasma phospholipids of patients with atopic eczema

Manku, M.S.; Horrobin, David F.; Morse, N.; Wright, S.; Burton, J.L.

doi:10.1111/j.1365-2133.1984.tb04698.x

Cited by 197 publications

(86 citation statements)

References 4 publications

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“…A first motive of interest attests that our results give credit to the hypothesis already drawn out by additional studies, of an enzyme deficit regarding the delta-6-desaturase, the first enzyme of the sequence forming AGL by adding a double link to LA [30]. We could also hypothesize a reduced ADGL production and then of PGE-1.…”

Section: Discussionsupporting

confidence: 52%

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Cantani¹

2015

J Biomol Res Ther

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Essential fatty acids (EFA) are the major components of cellular phospholipids (PLs), contributing to their stability and functions. They are also precursors of inflammation mediators such as prostaglandins and leukotrienes, and are involved in cellular immunoregulation.Most recent studies have stressed that EFA levels are important in various diseases. Several Authors have stated that patients with atopic dermatitis (AD) have altered EFA levels in plasmatic PLs, and showed clinical improvement after oral EFA administration. The aim of our work was to study EFA composition of PLs of cord blood lymphocytes in 32 newborns at risk for atopy, in order to correlate EFA levels at birth with total IgE values and with the onset of atopic disease. Thirty not at risk newborns were studied as controls.Our results demonstrate a significant decrease (p<0.0001) of arachidonic acid (AA) levels in lymphocytes of newborns at risk for atopy, compared to controls, whereas a not significant increase of linoleic acid (LA) was present. No reverse correlation between IgE values and AA levels was found, whereas the 6 month and 1 year follow-up have not shown any major alteration of total IgE values, on the contrary a normalization of AA levels in all but one child has been observed. Only this one child has developed AD. We stress that the preventive action on allergy development recognized to breast milk could be also due to its effect on the EFA composition of the PLs of cell membrane.

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Section: Discussionsupporting

confidence: 52%

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Cantani¹

2015

J Biomol Res Ther

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“…This has been corroborated for the ω–6 and the ω–3 series by some [3, 4], but not all other studies [5]. The clinical significance of these findings is controversial, however, since some randomised, placebo–controlled double–blind studies have shown a clinical improvement in patients with atopic eczema after treatment with Epogam, a GLA–rich oil from Evening primrose [6], while in other studies there was no effect of such treatment [7].…”

Section: Introductionsupporting

confidence: 66%

Polyunsaturated Fatty Acids in Breast Milk in Relation to Atopy in the Mother and Her Child

Duchén

Yu²,

Björkstén³

1999

Int Arch Allergy Immunol

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“…Adult patients with atopic eczema were compared with normal individuals with regards to the fatty acid composition of plasma phospholipids [47]. Linoleic acid (LA) concentration was slightly above normal while its metabolites GLA, dihomo-γ-linolenic acid (DGLA 20:3n-6) and arachidonic acid were below normal.…”

Section: Atopic Eczema and Psoriasismentioning

confidence: 99%

Alteration of polyunsaturated fatty acid status and metabolism in health and disease

Zamaria¹

2004

Reprod. Nutr. Dev.

119

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-Essential polyunsaturated fatty acids (PUFA) cannot be synthesised in the body and must be ingested by food. A balanced intake of both n-6 and n-3 PUFA is essential for good health. PUFA are the basic constituents of phospholipid membranes and determine cellular membrane fluidity and modulate enzyme activities, carriers and membrane receptors. They are also precursors of active metabolites known collectively as eicosanoids (prostaglandins, prostacyclins, thromboxanes and leukotrienes) which regulate our cellular functions. Studies indicate that n-3 PUFA have anti-inflammatory, antithrombotic, antiarrhythmic actions and immuno-modulating properties. Erythrocyte fatty acid status is a reflection of dietary fat intake. It also explores PUFA metabolism and gives information about the integration of these fatty acids into cellular membranes. Thus, erythrocyte fatty acid analysis can detect PUFA insufficiencies and imbalances from the diet, but also metabolic abnormalities and lipid peroxidation. It can be helpful in the prevention and the control of chronic diseases in which PUFA alterations have been observed as coronary heart diseases, hypertension, cancer, diabetes, inflammatory and auto-immune disorders, atopic eczema, Alzheimer dementia, major depression, schizophrenia, multiple sclerosis, etc.essential fatty acids / erythrocytes / metabolism / chronic diseases

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Essential fatty acids in the plasma phospholipids of patients with atopic eczema

Cited by 197 publications

References 4 publications

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Polyunsaturated Fatty Acids in Breast Milk in Relation to Atopy in the Mother and Her Child

Alteration of polyunsaturated fatty acid status and metabolism in health and disease

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