Essential fatty acids and breast cancer: A case-control study in Uruguay

Stéfani, Eduardo De; Deneo‐Pellegrini, Hugo; Mendilaharsu, Marı́a; Ronco, Álvaro L.

doi:10.1002/(sici)1097-0215(19980518)76:4<491::aid-ijc8>3.0.co;2-m

Cited by 62 publications

(20 citation statements)

References 30 publications

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“…Some of the case-control studies have reported positive [33, 34] relation of n-6 fatty acids intake with breast cancer risk. n-6 fatty acids by competition with n-3 fatty acids to produce eicosanoids increase the risk of breast cancer and also because of having many double bonds are easily oxidized and enhance cellular damage [35]. Moreover, a meta-analysis of cohort studies [36] and also a systematic review [37] showed an inverse association of n-3 fatty acids with breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy improves serum fatty acids and lipid profile in breast cancer

et al. 2017

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BackgroundBreast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer.MethodsIn this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile.ResultsAmong serum free and total fatty acids the major saturated fatty acids (SFAs) in serum lipids of breast cancer patients (pre and post treated) were stearic acid (18:0) and palmitic acid (16:0). These fatty acids contributed about 35-50% of total fatty acids. The decreased concentrations of linoleic acid (C18:2) and arachidonic acid (C20:4) with a lower ratio of C18:2/C18:1 was found in pretreated breast cancer patients as compared to controls. The n-3/n-6 ratio of breast cancer patients was decreased before treatment but it was 35% increased after treatment. In addition, plasma activity of D6 desaturase was increased in the breast cancer patients, while the activity of D5 desaturase was decreased. Increased levels of SFAs, monounsaturated fatty acids (MUFAs) and decreased polyunsaturated fatty acids (PUFAs) levels in breast cancer patients (pre and post treated) as compared to controls. Serum total cholesterol (TC) (224.4 mg/dL) and low density lipoprotein cholesterol (LDL-C) (142.9 mg/dL) were significantly increased in pretreated breast cancer patients but after the radiotherapy treatment, the TC (150.2 mg/dL) and LDL-C (89.8 mg/dL) were decreased.ConclusionIt seems that RT would have played a potential role in the treatment of BC. After RT the serum levels of PUFAs, TC, and LDL-C are improved. Our study reinforces the important role of RT in the management of BC.The level of PUFAs, TC, and LDL-C can be used as the biomarkers for early diagnosis in individuals with risk of breast cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0481-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Radiotherapy improves serum fatty acids and lipid profile in breast cancer

et al. 2017

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“…In recent years, the disease risk has been thoroughly studied from a dietary viewpoint (29)(30)(31)(32)(33)(34)(35)(36) but not yet from an anthropometric one. Besides, McTiernan (37) suggested the usefulness of case-control studies on anthropometric factors in racial and ethnic minorities since these groups have not been sufficiently studied to date, and they can provide information of potential biologic importance concerning their link to risk factors and markers as well as to the hormonal and metabolic mechanisms that underlie the associations between anthropometric factors and BC (38).…”

Section: Introductionmentioning

confidence: 99%

A Case-Control Study on Fat-to-Muscle Ratio and Risk of Breast Cancer

Ronco

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Stéfani

et al. 2009

Nutrition and Cancer

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Our objective was to analyze detailed anthropometric characterization for risk of breast cancer in Uruguayan women. The design was a case-control study. The setting was Pereira Rossell Women's Hospital, Montevideo, Uruguay. Subjects were 343 incident breast cancer cases and 1,042 frequency-matched healthy controls who were interviewed on menstrual and reproductive story; and a series of skin folds, circumferences, and diameters were measured to calculate fat and muscle fractions and the derived fat-to-muscle ratio (FMR). Odds ratio (ORs) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Muscle fraction was negatively associated with risk [OR for highest quartile = 0.23, 95% confidence interval (CI) = 0.15-0.34], fat fraction was positively associated (OR = 3.90, 95% CI = 2.62-5.80), and FMR was positively associated (OR = 4.45, 95% CI = 2.99-6.62). Stratified analyses by body mass index levels also showed risk increases for the highest tertiles of FMR, always displaying significant linear trends. Since increases of risk were found in overweight and in normal weight women, results suggest that fractions and amount of muscle and fat components might be risk factors for breast cancer on the basis of currently existing metabolic and immune interrelationships between adipose and muscular tissue given by glutamine, exercise-derived myokines, and other cytokines produced by these tissues.

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“…Los países con mayor número de estudios publicados son Uruguay [7][8][9]11,12,14,17,18 y México 10,13,[19][20][21][22][23]30 (33 y 30% de las publicaciones, respectivamente) (cuadro I). En Uruguay, los estudios se han enfocado sobre todo en el consumo de carnes y sus métodos de preparación.…”

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“…La investigación sobre dieta y CM conducida en diferentes países de Latinoamérica ha contribuido al estado del arte y muestra en particular el efecto protector de los vegetales y frutas, 5,9 el pescado, 12 la fibra, 17 la vitamina B 12 y el folato, 21 varios fitoestrógenos (en particular el flaván 3-ol y el pinoresinol), 23 el licopeno 9 y las grasas poliinsaturadas, 18,19 además del incremento del riesgo potencial de la elevada ingestión calórica, 5 el consumo de carnes rojas, 7,8,15,16 carnes procesadas, 14 la forma de preparación de las carnes, 12 leche y algunos productos lácteos, 11 grasas saturadas 7 y sacarosa, 20 además de compuestos secundarios como las aminas heterocíclicas. 8 No obstante, es importante mencionar que pese al gran número de proyectos realizados, un gran porcentaje de ellos carece de las características metodológicas que sustente con rigor científico los resultados.…”

Section: Discussionunclassified

Dieta y cáncer de mama en latinoamérica

et al. 2009

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Breast cancer (BC) is the primary cause of death from malignant tumors in women worldwide. Objective. Review epidemiological studies from the Latin-America and Caribbean (LAC) region. Material and Methods. A systematic search, carried out during June-November 2008 in Mexico of PubMed/Medline, Scielo, and Google identified 27 epidemiological studies in LAC that evaluated associations between diet and BC. Results. The research on diet and BC suggests the protective effect of certain fruits, vegetables, fish, fiber, vitamin B 12 , folate, various phytoestrogens, lycopene, and polyunsaturated fats; as well as the potential risk associated with elevated caloric consumption, consumption of red meat and processed meats, certain meat cooking techniques, milk and some other dairy products, saturated fat, and sucrose. Conclusions. The impact of specific foods and nutrients on breast cancer incidence is inconclusive. Further research is needed on this topic.

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Essential fatty acids and breast cancer: A case-control study in Uruguay

Cited by 62 publications

References 30 publications

Radiotherapy improves serum fatty acids and lipid profile in breast cancer

Radiotherapy improves serum fatty acids and lipid profile in breast cancer

A Case-Control Study on Fat-to-Muscle Ratio and Risk of Breast Cancer

Dieta y cáncer de mama en latinoamérica

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