Essential Factors to Make Excellent Biocompatibility of Phospholipid Polymer Materials

Ishihara, Kazuhíko; Inoue, Yasuo

doi:10.4028/www.scientific.net/ast.76.1

Cited by 4 publications

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“…Phospholipid polymers, in particular, the phosphorylcholine groups bearing polymers, have high potential in the biomedical field due to the excellent biocompatibility of the resulting biomaterials. − Among them, the water-soluble MPC polymers are attractive for the development of gene delivery vectors that show biocompatible properties, including low toxicity and low protein activation ability. The copolymers composed of the MPC unit and methacrylates with primary amines (AEMA and APMA) units were prepared by the reversible addition−fragmentation chain transfer (RAFT) polymerization method, which allowed the production of a series of cationic copolymers of controlled dimensions and architecture in the absence of metal catalysts. , The chemical structures of MPC, APMA, and AEMA were shown (Scheme ).…”

Section: Resultsmentioning

confidence: 99%

Well-Controlled Cationic Water-Soluble Phospholipid Polymer−DNA Nanocomplexes for Gene Delivery

et al. 2011

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The facile synthesis of biocompatible and nontoxic gene delivery vectors has been the focus of research in recent years due to the high potential in treating genetic diseases. 2-Methacryloxyethyl phosphorylcholine (MPC) copolymers were recently studied for their ability to produce nontoxic and biocompatible materials. The synthesis of well-defined and water-soluble MPC polymer based cationic vectors for gene delivery purposes was therefore attractive, due to the potential excellent biocompatibility of the resulting copolymers. Herein, cationic MPC copolymers of varying architectures (block versus random) were produced by the reversible addition--fragmentation chain transfer (RAFT) polymerization technique. The copolymers produced were evaluated for their gene delivery efficacy in the presence and absence of serum. It was found that copolymer architectures and molecular weights do affect their gene delivery efficacy. The statistical copolymers produced larger particles, and showed poor gene transfection efficiency as compared to the diblock copolymers. The diblock copolymers served as efficient gene delivery vectors, in both the presence and absence of serum in vitro. To the best of our knowledge, this is the first report where the effect of architecture of MPC based copolymer on gene delivery efficacy has been studied.

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Section: Resultsmentioning

confidence: 99%

Well-Controlled Cationic Water-Soluble Phospholipid Polymer−DNA Nanocomplexes for Gene Delivery

et al. 2011

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Surface Modification on Poly(ether ether ketone) with Phospholipid Polymer via Photoinduced Self‐Initiated Grafting

Ishihara

Inoue

Kyomoto

2015

Macromolecular Symposia

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A new and safer method for constructing a nanometer-scale modified surface on the poly(ether ether ketone) (PEEK) is examined by "photoinduced selfinitiated graft polymerization". The generation of semi-benzopinacol-containing radicals of the benzophenone units in PEEK molecular structure acted as a photoinitiator. This polymerization system is realized in the absence of a photoactive low molecular compound and in an aqueous medium; these are humanfriendly and exhibit excellent biocompatibility. In this study, we demonstrated the fabrication of modified surface with phospholipid polymer, i.e., poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) using the photoinduced self-initiated graft polymerization process. Effects of MPC concentration in the reacting solution and intensity of UV irradiation on the surface properties were examined. On the surface on PMPC-graft-PEEK, a significant reduction in the protein adsorption was observed. We conclude that the smart PMPC-graft-PEEK prepared by the photoinduced selfinitiated graft polymerization to produce PMPC layer on the surface will bring novel biomedical devices with both good mechanical property and biocompatible surface.

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High-efficiency preparation of poly(2-methacryloyloxyethyl phosphorylcholine) grafting layer on poly(ether ether ketone) by photoinduced and self-initiated graft polymerization in an aqueous solution in the presence of inorganic salt additives

et al. 2016

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Essential Factors to Make Excellent Biocompatibility of Phospholipid Polymer Materials

Cited by 4 publications

References 50 publications

Well-Controlled Cationic Water-Soluble Phospholipid Polymer−DNA Nanocomplexes for Gene Delivery

Well-Controlled Cationic Water-Soluble Phospholipid Polymer−DNA Nanocomplexes for Gene Delivery

Surface Modification on Poly(ether ether ketone) with Phospholipid Polymer via Photoinduced Self‐Initiated Grafting

High-efficiency preparation of poly(2-methacryloyloxyethyl phosphorylcholine) grafting layer on poly(ether ether ketone) by photoinduced and self-initiated graft polymerization in an aqueous solution in the presence of inorganic salt additives

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