Essential Elements for Enhanced Recovery After Intra-abdominal Surgery

Elhassan, Amir; Elhassan, Ihab; Elhassan, Amjad; Sekar, Krish D.; Rubin, Ryan; Urman, Richard D.; Cornett, Elyse M.; Kaye, Alan D.

doi:10.1007/s11916-019-0753-5

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…NAD + is a metabolic cofactor with a critical role in mitochondrial function, and restoring NAD + levels confers protection against age-associated diseases (21)(22)(23)(24)(25). Recent data suggest that supplementation with the NAD + precursor nicotinamide riboside (NR) reduces inflammaging in the elderly (26). Accordingly, we observed that NR decreased the serum levels of TNF-a in aged mice (fig.…”

Section: Ofmentioning

confidence: 75%

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

Desdín-Micó

Soto-Heredero

Aranda

et al. 2020

Science

330

264

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The effect of immunometabolism on age-associated diseases remains uncertain. In this work, we show that T cells with dysfunctional mitochondria owing to mitochondrial transcription factor A (TFAM) deficiency act as accelerators of senescence. In mice, these cells instigate multiple aging-related features, including metabolic, cognitive, physical, and cardiovascular alterations, which together result in premature death. T cell metabolic failure induces the accumulation of circulating cytokines, which resembles the chronic inflammation that is characteristic of aging (“inflammaging”). This cytokine storm itself acts as a systemic inducer of senescence. Blocking tumor necrosis factor–α signaling or preventing senescence with nicotinamide adenine dinucleotide precursors partially rescues premature aging in mice with Tfam-deficient T cells. Thus, T cells can regulate organismal fitness and life span, which highlights the importance of tight immunometabolic control in both aging and the onset of age-associated diseases.

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Section: Ofmentioning

confidence: 75%

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

Desdín-Micó

Soto-Heredero

Aranda

et al. 2020

Science

330

264

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“…These include pancreaticoduodenectomy, colorectal surgery, and bariatric surgery, to name a few. An understanding of the most commonly employed strategies with positive outcomes is essential for practitioners to design new ERAS protocols or pick appropriate interventions for a patient’s individualized ERAS plan [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

The application of enhanced recovery after surgery and negative-pressure wound therapy in the perioperative period of elderly patients with colorectal cancer

Liu

Yang²,

Zhu

2021

BMC Surg

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Objective To Explore the perioperative application of enhanced recovery after surgery (ERAS) and negative-pressure wound therapy in the elderly patients with colorectal cancer. Methods A retrospective clinical data were studied in the patients with colorectal cancer in Department of General Surgery in Shanghai Fourth People,s Hospital (from March, 2017 to March, 2019), One hundred and fifty patients with undergoing radical surgery for colorectal cancer were divided into two groups: ERAS group (n = 76 cases, accepting ERAS management) and Conventional treatment(CT) group (n = 74 cases, accepting traditional treatment), Bleeding in operation, the time of postoperative anal flatus, number of wound dressing changing, time of wound healing, the length of postoperative hospital stay, readmission rate, postoperative complication, were compared between the two groups. Results ERAS was associated with less bleeding in operation, less Wound fat liquefaction, less wound dressing changing, less time of wound healing, less time of postoperative anal flatus compare to CT group (P < 0.05); anastomotic fistula, readmission rate is similar in two groups (P > 0.05). Conclusion The modified ERAS can be safely applied to the perioperative period of elderly colorectal cancer patients and promote recovery; negative-pressure wound therapy is helpful for wound healing and promoting rehabilitation.

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“…Restrictive fluid replacement can effectively shorten the recovery time of gastrointestinal function, reduce cardiopulmonary complications, and improve wound healing. 25 But it will lead to insufficient circulating blood volume, affecting the intestinal tract. On this basis, the ERAS concept recommends GDFT, which can optimize organ perfusion and oxygen volume supply effectively reduce the incidence of infection, intestinal paralysis, intestinal obstruction, nausea and vomiting and improve PH value through monitoring indicators such as stroke volume variability (SVV) and arterial pulse pressure variability (PPV).…”

Section: Intraoperative Fluid Managementmentioning

confidence: 99%

Perioperative nursing principles guided by the concept of enhanced recovery after surgery^†

Xie

Cui

Shuang

2021

Frontiers of Nursing

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Objective To explore the clinical effect of perioperative nursing guided by the concept of enhanced recovery after surgery and summarize them. Methods Pubmed, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wanfang Database, and VIP Database were searched to obtain the relevant literature involving enhanced recovery after surgery (ERAS) guidance, obtain the effective clinical data, review the reports in literature, and obtain the effective scheme. Results Compared with the traditional nursing program, perioperative nursing principles guided by the concept of ERAS provide more accurate nursing care to patients and reduce the occurrence of intraoperative stress events through comprehensive nursing measures such as preoperative pre-rehabilitation measures, intraoperative body temperature and fluid management, postoperative analgesia, prevention of nausea and vomiting, early mobilization, catheter nursing, and better out-of-hospital follow-up. Conclusions Perioperative nursing principles guided by the concept of ERAS can significantly reduce the incidence of perioperative complications, shorten the hospital stay of patients, and promote postoperative rehabilitation of patients. The transformation and implementation of this concept can bring significant benefits to hospitals, medical care, and patients.

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Essential Elements for Enhanced Recovery After Intra-abdominal Surgery

Cited by 11 publications

References 30 publications

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

The application of enhanced recovery after surgery and negative-pressure wound therapy in the perioperative period of elderly patients with colorectal cancer

Perioperative nursing principles guided by the concept of enhanced recovery after surgery^†

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Essential Elements for Enhanced Recovery After Intra-abdominal Surgery

Cited by 11 publications

References 30 publications

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

The application of enhanced recovery after surgery and negative-pressure wound therapy in the perioperative period of elderly patients with colorectal cancer

Perioperative nursing principles guided by the concept of enhanced recovery after surgery†

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Product

Resources

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Perioperative nursing principles guided by the concept of enhanced recovery after surgery^†