Essential Elements and Isoflavonoids in the Prevention of Prostate Cancer

Stanisławska, Iwona; Figat, Ramona; Kiss, Anna K.; Bobrowska-Korczak, Barbara

doi:10.3390/nu14061225

Cited by 9 publications

(5 citation statements)

References 74 publications

(128 reference statements)

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“…Flavonoids are some of the main components of various plant extracts [ 20 ], with antitumor, antioxidant, antiviral, and rhinitis relief effects [ 39 , 40 , 41 ]. Isoflavonoids play an important role in the prevention of type 2 diabetes, the prevention and mitigation of kidney disease and cardiovascular disease, and the inhibition of prostate cancer cell proliferation [ 42 , 43 ]. Benzopyrans have therapeutic potential for atrial fibrillation [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology

He,

Tang,

Cao

et al. 2024

Molecules

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Bistorta vivipara is a medicinal plant with a long history, but there are few studies on the effects of its medicinal components and endophytic bacteria on the accumulation of secondary metabolites. Therefore, in this study, non-targeted metabolomics techniques and 16s rDNA techniques were used to study B. vivipara from different regions. A total of 1290 metabolites and 437 differential metabolites were identified from all samples. Among them, flavonoids, isoflavonoids, and benzopyrans are the main medicinal components of B. vivipara; these have potential anticancer, antiviral, and antioxidant properties, as well as potential applications for the treatment of atrial fibrillation. In addition, irigenin, an important medicinal component, was identified for the first time. The endophytic bacterial communities in the root tissues of B. vivipara from different regions were also different in composition and richness. Hierarchical clustering heat map analysis showed that Proteobacteria and Actinobacteriota bacteria significantly affected the accumulation of many medicinal components in the roots of B. vivipara.

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Section: Discussionmentioning

confidence: 99%

Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology

He,

Tang,

Cao

et al. 2024

Molecules

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“…Apart from food matrix components, absorption and bioavailability but also bioactivity in vitro may depend on further cofactors and nutrients. In cultured prostate cancer cells, isoflavones show antiproliferative and antigenotoxic effects, which are enhanced by metal ions, in particular iron, copper and zinc ions [ 61 ]. In fact, the risk for prostate cancer incidence decreases with soy food consumption, which is not related to soy protein but has been referred to isoflavones [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of α1-Adrenergic, Non-Adrenergic and Neurogenic Human Prostate Smooth Muscle Contraction and of Stromal Cell Growth by the Isoflavones Genistein and Daidzein

Huang

Liu

et al. 2022

Nutrients

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Isoflavone-rich legumes, including soy, are used for food production, as dietary supplements and in traditional medicine. Soy consumption correlates negatively with benign prostatic hyperplasia (BPH) and voiding symptoms. However, isoflavone effects on the prostate are hardly known. Here, we examined the effects on human prostate smooth muscle contractions and stromal cell growth, which are driving factors of voiding symptoms in BPH. Smooth muscle contractions were induced in prostate tissues from radical prostatectomy. Growth-related functions were studied in cultured stromal cells (WPMY-1). Neurogenic, α1-adrenergic and non-adrenergic contractions were strongly inhibited with 50 µM and by around 50% with 10 µM genistein. Daidzein inhibited neurogenic contractions using 10 and 100 µM. Agonist-induced contractions were inhibited by 100 µM but not 10 µM daidzein. A combination of 6 µM genistein with 5 µM daidzein still inhibited neurogenic and agonist-induced contractions. Proliferation of WPMY-1 cells was inhibited by genistein (>50%) and daidzein (<50%). Genistein induced apoptosis and cell death (by seven-fold relative to controls), while daidzein induced cell death (6.4-fold) without apoptosis. Viability was reduced by genistein (maximum: 87%) and daidzein (62%). In conclusion, soy isoflavones exert sustained effects on prostate smooth muscle contractions and stromal cell growth, which may explain the inverse relationships between soy-rich nutrition, BPH and voiding symptoms.

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“…Isoflavonoids can be found in chickpeas, peanuts, pistachio, and soybeans [ 209 , 210 ], and they are very well known for their therapeutic properties, having anti-inflammatory, estrogenic, antiestrogenic, anticancer, antibiotic, and radical scavenging activities [ 209 ] and being involved as well in the prevention of cancer [ 210 ].…”

Section: Natural Antioxidants and Their Benefitsmentioning

confidence: 99%

The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae

Pruteanu

Bailey²,

Grădinaru

et al. 2023

Antioxidants

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It is more effective to maintain good health than to regain it after losing it. This work focuses on the biochemical defense mechanisms against free radicals and their role in building and maintaining antioxidant shields, aiming to show how to balance, as much as possible, the situations in which we are exposed to free radicals. To achieve this aim, foods, fruits, and marine algae with a high antioxidant content should constitute the basis of nutritional elements, since natural products are known to have significantly greater assimilation efficiency. This review also gives the perspective in which the use of antioxidants can extend the life of food products, by protecting them from damage caused by oxidation as well as their use as food additives.

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Essential Elements and Isoflavonoids in the Prevention of Prostate Cancer

Cited by 9 publications

References 74 publications

Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology

Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology

Inhibition of α1-Adrenergic, Non-Adrenergic and Neurogenic Human Prostate Smooth Muscle Contraction and of Stromal Cell Growth by the Isoflavones Genistein and Daidzein

The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae

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